Revisiting the Inscrutable Granular Cell Tumors in the Breast and Beyond: An Institutional Experience
Background: Granular cell tumors (GrCTs) are rare neoplasms derived from Schwann cells and can affect any part of the body. They are histologically categorized into benign (most common), atypical, or malignant (<2%) subtypes. Methods: A retrospective review of pathology-proven GrCTs at a tertiar...
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| Format: | Article |
| Language: | English |
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Kaviani Breast Disease Institute
2022-03-01
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| Series: | Archives of Breast Cancer |
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| Online Access: | https://www.archbreastcancer.com/index.php/abc/article/view/511 |
| _version_ | 1830227776933724160 |
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| author | Nayanatara Swamy Patrick Jennings Rachel Taylor Scott B Harter Asangi R Kumarapeli Gwendolyn Bryant-Smith |
| author_facet | Nayanatara Swamy Patrick Jennings Rachel Taylor Scott B Harter Asangi R Kumarapeli Gwendolyn Bryant-Smith |
| author_sort | Nayanatara Swamy |
| collection | DOAJ |
| description |
Background: Granular cell tumors (GrCTs) are rare neoplasms derived from Schwann cells and can affect any part of the body. They are histologically categorized into benign (most common), atypical, or malignant (<2%) subtypes.
Methods: A retrospective review of pathology-proven GrCTs at a tertiary hospital was done from 4/1/2014 to 3/31/2021. The patient age, gender, location of the tumor, and imaging findings were reviewed.
Results: A total of 18 patients with GrCTs were found over a period of 7 years. The sites of involvement ranged from the tongue to the heel. The most common site of occurrence was the esophagus. There were 2 cases of recurrences and 2 cases of multicentric GrCTs. In our study, we did not have atypical or malignant GrCTs.
Conclusion: Granular cell tumors are uncommon and primarily published as case reports and case series. Our seven-year review provides a comprehensive synopsis of this tumor in the breast and rest of the body. Their clinical and imaging features are non-characteristic, but histopathologic features with immunohistochemistry are diagnostic. Complete surgical excision with negative margins is the accepted standard of care. A global overview of this tumor will allow physicians to provide their patients with a better understanding of their diagnosis and prognosis.
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| first_indexed | 2024-12-18T10:00:31Z |
| format | Article |
| id | doaj.art-adc60c0ea9fe4c438ab9a95c8f0546eb |
| institution | Directory Open Access Journal |
| issn | 2383-0433 |
| language | English |
| last_indexed | 2024-12-18T10:00:31Z |
| publishDate | 2022-03-01 |
| publisher | Kaviani Breast Disease Institute |
| record_format | Article |
| series | Archives of Breast Cancer |
| spelling | doaj.art-adc60c0ea9fe4c438ab9a95c8f0546eb2022-12-21T21:11:40ZengKaviani Breast Disease InstituteArchives of Breast Cancer2383-04332022-03-0192Revisiting the Inscrutable Granular Cell Tumors in the Breast and Beyond: An Institutional ExperienceNayanatara Swamy0Patrick Jennings1Rachel Taylor2Scott B Harter3Asangi R Kumarapeli4Gwendolyn Bryant-Smith5University of Arkansas for Medical Sciences, Arkansas, USAUniversity of Arkansas for Medical Sciences, Arkansas, USAUniversity of Arkansas for Medical Sciences, Arkansas, USAUniversity of Arkansas for Medical Sciences, Arkansas, USADepartment of Pathology, Summa Health, USAUniversity of Arkansas for Medical Sciences, Arkansas, USA Background: Granular cell tumors (GrCTs) are rare neoplasms derived from Schwann cells and can affect any part of the body. They are histologically categorized into benign (most common), atypical, or malignant (<2%) subtypes. Methods: A retrospective review of pathology-proven GrCTs at a tertiary hospital was done from 4/1/2014 to 3/31/2021. The patient age, gender, location of the tumor, and imaging findings were reviewed. Results: A total of 18 patients with GrCTs were found over a period of 7 years. The sites of involvement ranged from the tongue to the heel. The most common site of occurrence was the esophagus. There were 2 cases of recurrences and 2 cases of multicentric GrCTs. In our study, we did not have atypical or malignant GrCTs. Conclusion: Granular cell tumors are uncommon and primarily published as case reports and case series. Our seven-year review provides a comprehensive synopsis of this tumor in the breast and rest of the body. Their clinical and imaging features are non-characteristic, but histopathologic features with immunohistochemistry are diagnostic. Complete surgical excision with negative margins is the accepted standard of care. A global overview of this tumor will allow physicians to provide their patients with a better understanding of their diagnosis and prognosis. https://www.archbreastcancer.com/index.php/abc/article/view/511Granular cell tumor, Schwann cells, African American, subcutaneous tissue, head and neck neoplasms. |
| spellingShingle | Nayanatara Swamy Patrick Jennings Rachel Taylor Scott B Harter Asangi R Kumarapeli Gwendolyn Bryant-Smith Revisiting the Inscrutable Granular Cell Tumors in the Breast and Beyond: An Institutional Experience Archives of Breast Cancer Granular cell tumor, Schwann cells, African American, subcutaneous tissue, head and neck neoplasms. |
| title | Revisiting the Inscrutable Granular Cell Tumors in the Breast and Beyond: An Institutional Experience |
| title_full | Revisiting the Inscrutable Granular Cell Tumors in the Breast and Beyond: An Institutional Experience |
| title_fullStr | Revisiting the Inscrutable Granular Cell Tumors in the Breast and Beyond: An Institutional Experience |
| title_full_unstemmed | Revisiting the Inscrutable Granular Cell Tumors in the Breast and Beyond: An Institutional Experience |
| title_short | Revisiting the Inscrutable Granular Cell Tumors in the Breast and Beyond: An Institutional Experience |
| title_sort | revisiting the inscrutable granular cell tumors in the breast and beyond an institutional experience |
| topic | Granular cell tumor, Schwann cells, African American, subcutaneous tissue, head and neck neoplasms. |
| url | https://www.archbreastcancer.com/index.php/abc/article/view/511 |
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