PROSPECTS FOR USING COLCHICINE IN MEDICINE: NEW EVIDENCE
Immune-mediated inflammatory diseases (IMIDs) belong to the most severe chronic human diseases. The leading mechanisms of the development of IMIDs are, in the broad sense of the word, autoimmune and/or autoinflammatory immunopathological processes, the former of which is characterized by the prepond...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2020-04-01
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| Series: | Научно-практическая ревматология |
| Subjects: | |
| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2876 |
| _version_ | 1797862598269468672 |
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| author | Z. S. Alekberova E. L. Nasonov |
| author_facet | Z. S. Alekberova E. L. Nasonov |
| author_sort | Z. S. Alekberova |
| collection | DOAJ |
| description | Immune-mediated inflammatory diseases (IMIDs) belong to the most severe chronic human diseases. The leading mechanisms of the development of IMIDs are, in the broad sense of the word, autoimmune and/or autoinflammatory immunopathological processes, the former of which is characterized by the preponderance of activation of acquired immunity, and the latter is by that of innate immunity. A broad spectrum of anti-inflammatory drugs is used to treat IMIDs. Regardless of their structure and molecular targets, the dominant universal effect of the drugs is in suppressing inflammation. A special place is occupied by colchicine that is an alkaloid extracted from meadow saffron (Colchicum autumnale), which has been used to treat joint inflammation for more than 2 thousand years, and has unique, not fully deciphered mechanisms that determine its anti-inflammatory and analgesic effects. Owing to the deciphering of the molecular mechanisms of action of colchicine in suppressing the autoinflammatory mechanisms in the immunological pathogenesis of IMIDs, the interest in colchicine has substantially increased and contributed to the expansion of indications for its use in medicine. |
| first_indexed | 2024-04-09T22:23:16Z |
| format | Article |
| id | doaj.art-adc6437fd1ec4a98ba962c51b2f91611 |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2024-04-09T22:23:16Z |
| publishDate | 2020-04-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-adc6437fd1ec4a98ba962c51b2f916112023-03-22T13:45:56ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922020-04-0158218319010.14412/1995-4484-2020-183-1902599PROSPECTS FOR USING COLCHICINE IN MEDICINE: NEW EVIDENCEZ. S. Alekberova0E. L. Nasonov1V.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaImmune-mediated inflammatory diseases (IMIDs) belong to the most severe chronic human diseases. The leading mechanisms of the development of IMIDs are, in the broad sense of the word, autoimmune and/or autoinflammatory immunopathological processes, the former of which is characterized by the preponderance of activation of acquired immunity, and the latter is by that of innate immunity. A broad spectrum of anti-inflammatory drugs is used to treat IMIDs. Regardless of their structure and molecular targets, the dominant universal effect of the drugs is in suppressing inflammation. A special place is occupied by colchicine that is an alkaloid extracted from meadow saffron (Colchicum autumnale), which has been used to treat joint inflammation for more than 2 thousand years, and has unique, not fully deciphered mechanisms that determine its anti-inflammatory and analgesic effects. Owing to the deciphering of the molecular mechanisms of action of colchicine in suppressing the autoinflammatory mechanisms in the immunological pathogenesis of IMIDs, the interest in colchicine has substantially increased and contributed to the expansion of indications for its use in medicine.https://rsp.mediar-press.net/rsp/article/view/2876colchicineautoinflammatory diseasesgoutfamilial mediterranean feverbehсet's diseaseatherosclerosis |
| spellingShingle | Z. S. Alekberova E. L. Nasonov PROSPECTS FOR USING COLCHICINE IN MEDICINE: NEW EVIDENCE Научно-практическая ревматология colchicine autoinflammatory diseases gout familial mediterranean fever behсet's disease atherosclerosis |
| title | PROSPECTS FOR USING COLCHICINE IN MEDICINE: NEW EVIDENCE |
| title_full | PROSPECTS FOR USING COLCHICINE IN MEDICINE: NEW EVIDENCE |
| title_fullStr | PROSPECTS FOR USING COLCHICINE IN MEDICINE: NEW EVIDENCE |
| title_full_unstemmed | PROSPECTS FOR USING COLCHICINE IN MEDICINE: NEW EVIDENCE |
| title_short | PROSPECTS FOR USING COLCHICINE IN MEDICINE: NEW EVIDENCE |
| title_sort | prospects for using colchicine in medicine new evidence |
| topic | colchicine autoinflammatory diseases gout familial mediterranean fever behсet's disease atherosclerosis |
| url | https://rsp.mediar-press.net/rsp/article/view/2876 |
| work_keys_str_mv | AT zsalekberova prospectsforusingcolchicineinmedicinenewevidence AT elnasonov prospectsforusingcolchicineinmedicinenewevidence |