Synergy between Active Efflux and Outer Membrane Diffusion Defines Rules of Antibiotic Permeation into Gram-Negative Bacteria

Synergy between Active Efflux and Outer Membrane Diffusion Defines Rules of Antibiotic Permeation into Gram-Negative Bacteria

ABSTRACT Gram-negative bacteria are notoriously resistant to antibiotics, but the extent of the resistance varies broadly between species. We report that in significant human pathogens Acinetobacter baumannii, Pseudomonas aeruginosa, and Burkholderia spp., the differences in antibiotic resistance ar...

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Bibliographic Details
Main Authors: Ganesh Krishnamoorthy, Inga V. Leus, Jon W. Weeks, David Wolloscheck, Valentin V. Rybenkov, Helen I. Zgurskaya
Format: Article
Language:English
Published: American Society for Microbiology 2017-11-01
Series:mBio
Subjects:
Acinetobacter
Burkholderia
Pseudomonas aeruginosa
antibiotic resistance
multidrug efflux
outer membrane
Online Access:https://journals.asm.org/doi/10.1128/mBio.01172-17

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