Synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides

The paper is focused on the synthesis and screening of the antiplasmodial activity of novel fumardiamides 5–10 with the mefloquine pharmacophore and a Michael acceptor motif. Multi-step reactions leading to the title compounds included two amide bond formations. The first amide bond was achieved by...

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Бібліографічні деталі
Автори: Beus Maja, Fontinha Diana, Held Jana, Rajić Zrinka, Prudêncio Miguel, Zorc Branka
Формат: Стаття
Мова:English
Опубліковано: Sciendo 2019-06-01
Серія:Acta Pharmaceutica
Предмети:
Онлайн доступ:https://doi.org/10.2478/acph-2019-0019