Genomics-Microbiome Based Assessment of Bidirectional Causality Between Gut Microbiota and Psoriasis
Qian Gao,1,2 Jing-Hua Liu,1,2 Wen-Yi Ma,1,2 Zi-Lin Cheng,1,2 Ping-Sheng Hao,1 Na-Na Luo1 1Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of ChinaCorrespondence: Ping-...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-02-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/genomics-microbiome-based-assessment-of-bidirectional-causality-betwee-peer-reviewed-fulltext-article-CCID |
| _version_ | 1797311736428101632 |
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| author | Gao Q Liu JH Ma WY Cheng ZL Hao PS Luo NN |
| author_facet | Gao Q Liu JH Ma WY Cheng ZL Hao PS Luo NN |
| author_sort | Gao Q |
| collection | DOAJ |
| description | Qian Gao,1,2 Jing-Hua Liu,1,2 Wen-Yi Ma,1,2 Zi-Lin Cheng,1,2 Ping-Sheng Hao,1 Na-Na Luo1 1Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of ChinaCorrespondence: Ping-Sheng Hao; Na-Na Luo, Email hpswl@126.com; 982820421@qq.comBackground: Traditional observational studies have found a possible risk association of the gut microbiota for psoriasis. Meanwhile, psoriasis may also affect the changes in the gut microbiota. However, the available evidence does not demonstrate a reciprocal relationship between the gut microbiota and psoriasis. This limits our understanding on the role of the gut microbiota in the mechanisms of psoriasis.Methods: To address this question we used Mendelian randomization, a novel epidemiological approach, and acquired the largest current gut microbiota GWAS data from the MiBioGen consortium as well as psoriasis GWAS data from the FinnGen consortium, and performed two-sample bidirectional MR analyses using a multiple MR analysis approach. Finally, the robustness of the results was assessed by sensitivity analysis.Results: Our results indicate that five bacterial genera are causally related to psoriasis and psoriasis is causally related to four bacterial genera.Conclusion: These results suggest a bidirectional causal influence of psoriasis on the gut microbiota. Our results somewhat challenge the causal inferences of previous observational studies. We found that the specific bacterial genera with a risk effect on psoriasis were different from those found to characterize psoriasis in previous observational studies, and that these psoriasis-characterizing genera were inversely associated with psoriasis.Keywords: Mendelian randomization, psoriasis, causal relationship, gut microbiota, bidirectional Mendelian randomization analysis |
| first_indexed | 2024-03-08T02:03:59Z |
| format | Article |
| id | doaj.art-adca65e153c448dbb9fd51364b30a02e |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-03-08T02:03:59Z |
| publishDate | 2024-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-adca65e153c448dbb9fd51364b30a02e2024-02-13T19:43:10ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152024-02-01Volume 1743544590435Genomics-Microbiome Based Assessment of Bidirectional Causality Between Gut Microbiota and PsoriasisGao QLiu JHMa WYCheng ZLHao PSLuo NNQian Gao,1,2 Jing-Hua Liu,1,2 Wen-Yi Ma,1,2 Zi-Lin Cheng,1,2 Ping-Sheng Hao,1 Na-Na Luo1 1Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of ChinaCorrespondence: Ping-Sheng Hao; Na-Na Luo, Email hpswl@126.com; 982820421@qq.comBackground: Traditional observational studies have found a possible risk association of the gut microbiota for psoriasis. Meanwhile, psoriasis may also affect the changes in the gut microbiota. However, the available evidence does not demonstrate a reciprocal relationship between the gut microbiota and psoriasis. This limits our understanding on the role of the gut microbiota in the mechanisms of psoriasis.Methods: To address this question we used Mendelian randomization, a novel epidemiological approach, and acquired the largest current gut microbiota GWAS data from the MiBioGen consortium as well as psoriasis GWAS data from the FinnGen consortium, and performed two-sample bidirectional MR analyses using a multiple MR analysis approach. Finally, the robustness of the results was assessed by sensitivity analysis.Results: Our results indicate that five bacterial genera are causally related to psoriasis and psoriasis is causally related to four bacterial genera.Conclusion: These results suggest a bidirectional causal influence of psoriasis on the gut microbiota. Our results somewhat challenge the causal inferences of previous observational studies. We found that the specific bacterial genera with a risk effect on psoriasis were different from those found to characterize psoriasis in previous observational studies, and that these psoriasis-characterizing genera were inversely associated with psoriasis.Keywords: Mendelian randomization, psoriasis, causal relationship, gut microbiota, bidirectional Mendelian randomization analysishttps://www.dovepress.com/genomics-microbiome-based-assessment-of-bidirectional-causality-betwee-peer-reviewed-fulltext-article-CCIDmendelian randomizationpsoriasiscausal relationshipgut microbiotabidirectional mendelian randomization analysis. |
| spellingShingle | Gao Q Liu JH Ma WY Cheng ZL Hao PS Luo NN Genomics-Microbiome Based Assessment of Bidirectional Causality Between Gut Microbiota and Psoriasis Clinical, Cosmetic and Investigational Dermatology mendelian randomization psoriasis causal relationship gut microbiota bidirectional mendelian randomization analysis. |
| title | Genomics-Microbiome Based Assessment of Bidirectional Causality Between Gut Microbiota and Psoriasis |
| title_full | Genomics-Microbiome Based Assessment of Bidirectional Causality Between Gut Microbiota and Psoriasis |
| title_fullStr | Genomics-Microbiome Based Assessment of Bidirectional Causality Between Gut Microbiota and Psoriasis |
| title_full_unstemmed | Genomics-Microbiome Based Assessment of Bidirectional Causality Between Gut Microbiota and Psoriasis |
| title_short | Genomics-Microbiome Based Assessment of Bidirectional Causality Between Gut Microbiota and Psoriasis |
| title_sort | genomics microbiome based assessment of bidirectional causality between gut microbiota and psoriasis |
| topic | mendelian randomization psoriasis causal relationship gut microbiota bidirectional mendelian randomization analysis. |
| url | https://www.dovepress.com/genomics-microbiome-based-assessment-of-bidirectional-causality-betwee-peer-reviewed-fulltext-article-CCID |
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