MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling

MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling

Abstract Background Chemotherapeutic agents that modulate cell cycle checkpoints and/or tumor-specific pathways have shown immense promise in preclinical and clinical studies aimed at anti-cancer therapy. MASTL (Greatwall in Xenopus and Drosophila), a serine/threonine kinase controls the final G2/M...

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Main Authors: Srijayaprakash Babu Uppada, Saiprasad Gowrikumar, Rizwan Ahmad, Balawant Kumar, Bryan Szeglin, Xi Chen, J. Joshua Smith, Surinder K. Batra, Amar B. Singh, Punita Dhawan
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Molecular Cancer
Subjects:
Colon cancer
Wnt signaling and MASTL
Online Access:http://link.springer.com/article/10.1186/s12943-018-0848-3

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