LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN CORONARY HEART DISEASE: ASSESSMENT OF TELMISARTAN AND ENALAPRIL EFFECTIVENESS
Aim: To assess enalapril and telmisartan effects on hemodynamic parameters and left ventricular (LV) diastolic dysfunction (DD) in patients with coronary heart disease (CHD) and arterial hypertension (AH). Material and methods: In total, 51 men with stable CHD (mean age 57,3+3,4 years) were examined...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2010-02-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1419 |
| _version_ | 1826561507236773888 |
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| author | I. P. Tatarchenko N. V. Pozdnyakova S. A. Sekerko K. V. Solovyeva |
| author_facet | I. P. Tatarchenko N. V. Pozdnyakova S. A. Sekerko K. V. Solovyeva |
| author_sort | I. P. Tatarchenko |
| collection | DOAJ |
| description | Aim: To assess enalapril and telmisartan effects on hemodynamic parameters and left ventricular (LV) diastolic dysfunction (DD) in patients with coronary heart disease (CHD) and arterial hypertension (AH). Material and methods: In total, 51 men with stable CHD (mean age 57,3+3,4 years) were examined. The methods included general clinical and laboratory examination, 24-hour blood pressure monitoring, Holter ECG monitoring, and echocardiography. Results: In patients with CHD and abnormal relaxation LVDD, telmisartan therapy improved transmitral diastolic blood flow parameters: IVRT increased to 25%, DT – to 13,4%, E/A ratio – to 23%. Diastolic function improvement was associated with decreased LV myocardial mass index (5,6%), reduced circadian duration of myocardial ischemia, increased LV ejection fraction (9,6%), and increased fraction of systolic LV antero-posterior shortening (17,2%). The beneficial effects of telmisartan could be explained by optimised LV relaxation and early and late diastolic filling. |
| first_indexed | 2024-04-09T20:52:22Z |
| format | Article |
| id | doaj.art-adcc4ae91a2942228b84f9f406725553 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2025-03-14T09:33:16Z |
| publishDate | 2010-02-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-adcc4ae91a2942228b84f9f4067255532025-03-02T11:42:26Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202010-02-010147531207LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN CORONARY HEART DISEASE: ASSESSMENT OF TELMISARTAN AND ENALAPRIL EFFECTIVENESSI. P. Tatarchenko0N. V. Pozdnyakova1S. A. Sekerko2K. V. Solovyeva3Пензенский институт усовершенствования врачей РосздраваМедико-санитарная часть №59Федерального медико-биологического агентства России, ПензаПензенский институт усовершенствования врачей РосздраваПензенский институт усовершенствования врачей РосздраваAim: To assess enalapril and telmisartan effects on hemodynamic parameters and left ventricular (LV) diastolic dysfunction (DD) in patients with coronary heart disease (CHD) and arterial hypertension (AH). Material and methods: In total, 51 men with stable CHD (mean age 57,3+3,4 years) were examined. The methods included general clinical and laboratory examination, 24-hour blood pressure monitoring, Holter ECG monitoring, and echocardiography. Results: In patients with CHD and abnormal relaxation LVDD, telmisartan therapy improved transmitral diastolic blood flow parameters: IVRT increased to 25%, DT – to 13,4%, E/A ratio – to 23%. Diastolic function improvement was associated with decreased LV myocardial mass index (5,6%), reduced circadian duration of myocardial ischemia, increased LV ejection fraction (9,6%), and increased fraction of systolic LV antero-posterior shortening (17,2%). The beneficial effects of telmisartan could be explained by optimised LV relaxation and early and late diastolic filling.https://russjcardiol.elpub.ru/jour/article/view/1419coronary heart diseaseleft ventricular diastolic dysfunctionangiotensin receptor antagonists |
| spellingShingle | I. P. Tatarchenko N. V. Pozdnyakova S. A. Sekerko K. V. Solovyeva LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN CORONARY HEART DISEASE: ASSESSMENT OF TELMISARTAN AND ENALAPRIL EFFECTIVENESS Российский кардиологический журнал coronary heart disease left ventricular diastolic dysfunction angiotensin receptor antagonists |
| title | LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN CORONARY HEART DISEASE: ASSESSMENT OF TELMISARTAN AND ENALAPRIL EFFECTIVENESS |
| title_full | LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN CORONARY HEART DISEASE: ASSESSMENT OF TELMISARTAN AND ENALAPRIL EFFECTIVENESS |
| title_fullStr | LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN CORONARY HEART DISEASE: ASSESSMENT OF TELMISARTAN AND ENALAPRIL EFFECTIVENESS |
| title_full_unstemmed | LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN CORONARY HEART DISEASE: ASSESSMENT OF TELMISARTAN AND ENALAPRIL EFFECTIVENESS |
| title_short | LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN CORONARY HEART DISEASE: ASSESSMENT OF TELMISARTAN AND ENALAPRIL EFFECTIVENESS |
| title_sort | left ventricular diastolic dysfunction in coronary heart disease assessment of telmisartan and enalapril effectiveness |
| topic | coronary heart disease left ventricular diastolic dysfunction angiotensin receptor antagonists |
| url | https://russjcardiol.elpub.ru/jour/article/view/1419 |
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