NeoCheck: a prescription-screening tool to optimise pharmacotherapy for hospitalised neonates
AIMS OF THE STUDY To develop a screening tool to optimise neonatal drug prescription, which is often based on low-quality evidence. METHODS Neonatal pharmacotherapy recommendations were identified by literature review and synthesised into NeoCheck tool statements. In a two-round modified Delph...
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| Format: | Article |
| Language: | English |
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SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2021-06-01
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| Series: | Swiss Medical Weekly |
| Subjects: | |
| Online Access: | https://www.smw.ch/index.php/smw/article/view/3025 |
| _version_ | 1797974921554427904 |
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| author | Thomas Rudolf von Rohr Roberta de Luca Pascal Bonnabry Riccardo E. Pfister Caroline Fonzo-Christe |
| author_facet | Thomas Rudolf von Rohr Roberta de Luca Pascal Bonnabry Riccardo E. Pfister Caroline Fonzo-Christe |
| author_sort | Thomas Rudolf von Rohr |
| collection | DOAJ |
| description |
AIMS OF THE STUDY
To develop a screening tool to optimise neonatal drug prescription, which is often based on low-quality evidence.
METHODS
Neonatal pharmacotherapy recommendations were identified by literature review and synthesised into NeoCheck tool statements. In a two-round modified Delphi process, experts from Swiss neonatal intensive care units (NICUs) rated their agreement with individual statements using a five-point Likert scale (5 = totally agree). Statements with >65% scores ≥4 in round 1 and >75% scores ≥4 in round 2 were selected.
RESULTS
We identified 1375 clinical guidelines via literature review. After synthesis, 158 statements were submitted to 23 experts (1 clinical pharmacist, 22 neonatologists; 65% with >10 years neonatology practice) from 10 Swiss NICUs. Nineteen items did not reach the agreement threshold and were eliminated in the second Delphi round. The final NeoCheck tool comprises 141 statements in 11 medical domains concerning 49 neonatal diseases. Most (79%) statements concern all neonates, 13% concern preterm (<37 weeks gestational age) infants and 3% concern very preterm (<32 weeks gestational age) infants
CONCLUSIONS
NeoCheck is the first prescription-screening tool developed to optimise neonatal pharmacotherapy. In a future prospective study, its effect on NICU prescription optimisation and the quality of care will be assessed.
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| first_indexed | 2024-04-11T04:27:23Z |
| format | Article |
| id | doaj.art-adcd54e159634bd68bbfa5aa11a9fac7 |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2024-04-11T04:27:23Z |
| publishDate | 2021-06-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-adcd54e159634bd68bbfa5aa11a9fac72022-12-29T16:01:34ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972021-06-01151252610.4414/smw.2021.20519NeoCheck: a prescription-screening tool to optimise pharmacotherapy for hospitalised neonatesThomas Rudolf von Rohr0Roberta de Luca1Pascal Bonnabry2Riccardo E. Pfister3Caroline Fonzo-Christe4Pharmacy, Geneva University Hospitals, Geneva, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, SwitzerlandNeonatology Unit, Hôpital de la Tour, Meyrin, SwitzerlandPharmacy, Geneva University Hospitals, Geneva, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, SwitzerlandNeonatology and Paediatric Intensive Care Unit, Geneva University Hospitals, Geneva, SwitzerlandPharmacy, Geneva University Hospitals, Geneva, Switzerland; Neonatology and Paediatric Intensive Care Unit, Geneva University Hospitals, Geneva, Switzerland AIMS OF THE STUDY To develop a screening tool to optimise neonatal drug prescription, which is often based on low-quality evidence. METHODS Neonatal pharmacotherapy recommendations were identified by literature review and synthesised into NeoCheck tool statements. In a two-round modified Delphi process, experts from Swiss neonatal intensive care units (NICUs) rated their agreement with individual statements using a five-point Likert scale (5 = totally agree). Statements with >65% scores ≥4 in round 1 and >75% scores ≥4 in round 2 were selected. RESULTS We identified 1375 clinical guidelines via literature review. After synthesis, 158 statements were submitted to 23 experts (1 clinical pharmacist, 22 neonatologists; 65% with >10 years neonatology practice) from 10 Swiss NICUs. Nineteen items did not reach the agreement threshold and were eliminated in the second Delphi round. The final NeoCheck tool comprises 141 statements in 11 medical domains concerning 49 neonatal diseases. Most (79%) statements concern all neonates, 13% concern preterm (<37 weeks gestational age) infants and 3% concern very preterm (<32 weeks gestational age) infants CONCLUSIONS NeoCheck is the first prescription-screening tool developed to optimise neonatal pharmacotherapy. In a future prospective study, its effect on NICU prescription optimisation and the quality of care will be assessed. https://www.smw.ch/index.php/smw/article/view/3025neonatepharmacotherapypotentially inappropriate medicationprescription-screening toolQuality of Care |
| spellingShingle | Thomas Rudolf von Rohr Roberta de Luca Pascal Bonnabry Riccardo E. Pfister Caroline Fonzo-Christe NeoCheck: a prescription-screening tool to optimise pharmacotherapy for hospitalised neonates Swiss Medical Weekly neonate pharmacotherapy potentially inappropriate medication prescription-screening tool Quality of Care |
| title | NeoCheck: a prescription-screening tool to optimise pharmacotherapy for hospitalised neonates |
| title_full | NeoCheck: a prescription-screening tool to optimise pharmacotherapy for hospitalised neonates |
| title_fullStr | NeoCheck: a prescription-screening tool to optimise pharmacotherapy for hospitalised neonates |
| title_full_unstemmed | NeoCheck: a prescription-screening tool to optimise pharmacotherapy for hospitalised neonates |
| title_short | NeoCheck: a prescription-screening tool to optimise pharmacotherapy for hospitalised neonates |
| title_sort | neocheck a prescription screening tool to optimise pharmacotherapy for hospitalised neonates |
| topic | neonate pharmacotherapy potentially inappropriate medication prescription-screening tool Quality of Care |
| url | https://www.smw.ch/index.php/smw/article/view/3025 |
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