Chemistry of Bridged Lactams: Recent Developments
Bridged lactams represent the most effective and wide-ranging method of constraining the amide bond in a non-planar conformation. A previous comprehensive review on this topic was published in 2013 (Chem. Rev. 2013, 113, 5701–5765). In the present review, which is published as a part of th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-01-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/24/2/274 |
| _version_ | 1828233532554608640 |
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| author | Roman Szostak Michal Szostak |
| author_facet | Roman Szostak Michal Szostak |
| author_sort | Roman Szostak |
| collection | DOAJ |
| description | Bridged lactams represent the most effective and wide-ranging method of constraining the amide bond in a non-planar conformation. A previous comprehensive review on this topic was published in 2013 (Chem. Rev. 2013, 113, 5701–5765). In the present review, which is published as a part of the Special Issue on Amide Bond Activation, we present an overview of the recent developments in the field of bridged lactams that have taken place in the last five years and present a critical assessment of the current status of bridged lactams in synthetic and physical organic chemistry. This review covers the period from 2014 until the end of 2018 and is intended as an update to Chem. Rev. 2013, 113, 5701–5765. In addition to bridged lactams, the review covers recent advances in the chemistry of bridged sultams, bridged enamines and related non-planar structures. |
| first_indexed | 2024-04-12T19:39:54Z |
| format | Article |
| id | doaj.art-adcf76a35a984bb88f4eb016717c5568 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T19:39:54Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-adcf76a35a984bb88f4eb016717c55682022-12-22T03:19:06ZengMDPI AGMolecules1420-30492019-01-0124227410.3390/molecules24020274molecules24020274Chemistry of Bridged Lactams: Recent DevelopmentsRoman Szostak0Michal Szostak1Department of Chemistry, Wroclaw University, F. Joliot-Curie 14, 50-383 Wroclaw, PolandDepartment of Chemistry, Rutgers University, 73 Warren Street, Newark, NJ 07102, USABridged lactams represent the most effective and wide-ranging method of constraining the amide bond in a non-planar conformation. A previous comprehensive review on this topic was published in 2013 (Chem. Rev. 2013, 113, 5701–5765). In the present review, which is published as a part of the Special Issue on Amide Bond Activation, we present an overview of the recent developments in the field of bridged lactams that have taken place in the last five years and present a critical assessment of the current status of bridged lactams in synthetic and physical organic chemistry. This review covers the period from 2014 until the end of 2018 and is intended as an update to Chem. Rev. 2013, 113, 5701–5765. In addition to bridged lactams, the review covers recent advances in the chemistry of bridged sultams, bridged enamines and related non-planar structures.http://www.mdpi.com/1420-3049/24/2/274amide bondbridged lactamstwisted amidesamidesWinkler-Dunitz parametersN–C activationhypersensitivitynitrogen heterocyclesdistortionbridged sultams |
| spellingShingle | Roman Szostak Michal Szostak Chemistry of Bridged Lactams: Recent Developments Molecules amide bond bridged lactams twisted amides amides Winkler-Dunitz parameters N–C activation hypersensitivity nitrogen heterocycles distortion bridged sultams |
| title | Chemistry of Bridged Lactams: Recent Developments |
| title_full | Chemistry of Bridged Lactams: Recent Developments |
| title_fullStr | Chemistry of Bridged Lactams: Recent Developments |
| title_full_unstemmed | Chemistry of Bridged Lactams: Recent Developments |
| title_short | Chemistry of Bridged Lactams: Recent Developments |
| title_sort | chemistry of bridged lactams recent developments |
| topic | amide bond bridged lactams twisted amides amides Winkler-Dunitz parameters N–C activation hypersensitivity nitrogen heterocycles distortion bridged sultams |
| url | http://www.mdpi.com/1420-3049/24/2/274 |
| work_keys_str_mv | AT romanszostak chemistryofbridgedlactamsrecentdevelopments AT michalszostak chemistryofbridgedlactamsrecentdevelopments |