Role of diffusion weighted MR-imaging in the evaluation of malignant mediastinal lesions
Abstract Background Conducted studies showed that the ADC (apparent diffusion coefficient) values of malignant mediastinal lesions are significantly lower than those of benign lesions. Investigators determined cut-off ADC values to differentiate the two; concluding that ADC value is a promising noni...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-02-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
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| Online Access: | https://doi.org/10.1186/s43055-020-0132-6 |
| _version_ | 1819048673009467392 |
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| author | Youssriah Yahia Sabri Eman Zaki Bassyouni Nossair HebatAllah Hany Assal Hisham Samir Wahba |
| author_facet | Youssriah Yahia Sabri Eman Zaki Bassyouni Nossair HebatAllah Hany Assal Hisham Samir Wahba |
| author_sort | Youssriah Yahia Sabri |
| collection | DOAJ |
| description | Abstract Background Conducted studies showed that the ADC (apparent diffusion coefficient) values of malignant mediastinal lesions are significantly lower than those of benign lesions. Investigators determined cut-off ADC values to differentiate the two; concluding that ADC value is a promising noninvasive, imaging parameter that helps assess and characterize mediastinal tumors. Taking this a step forward, the primary objective of our prospective study was to investigate the potential of DW-MRI (diffusion-weighted magnetic resonance imaging) to characterize malignant mediastinal lesions using their ADC values. Thirty-three patients that underwent MRI of the chest with DWI and latter pathologically diagnosed with a malignant mediastinal lesion were included in this study. Lesions’ ADC values were measured and correlated with the histopathological results. The statistical significance of differences between measurements was tested using the one-way ANOVA (analysis of variance) test; p values equal to or less than 0.05 were considered significant. Results There was no statistically significant difference between the ADCmean values of the histopathological groups of lesions assessed with the overlap of their ADCmean values. The average ADCmean value of NHL (non-Hodgkin lymphoma) was evidently lower than that of HD (Hodgkin disease) with no overlap between their ADCmean values. DWI failed at characterizing one lesion in this study as a malignant tumor, namely an immature teratoma (germ-cell tumor). Again DWI could not be used to evaluate a mass, latter pathologically diagnosed as an angiosarcoma, because of its overall hemorrhagic nature showing no definite non-hemorrhagic soft tissue components. The aforementioned results did not differ considerably when minimum ADC was used instead of mean ADC. Conclusion There was no statistically significant difference between the ADC values of the malignant mediastinal lesions evaluated. However, regarding lymphoma subtypes, our limited sample study of lymphoma suggested a considerable difference between the ADC values of Hodgkin disease and non-Hodgkin lymphoma. |
| first_indexed | 2024-12-21T11:19:59Z |
| format | Article |
| id | doaj.art-add01ea19c77410e9306bfb80bd5010e |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-12-21T11:19:59Z |
| publishDate | 2020-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-add01ea19c77410e9306bfb80bd5010e2022-12-21T19:05:48ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622020-02-0151111610.1186/s43055-020-0132-6Role of diffusion weighted MR-imaging in the evaluation of malignant mediastinal lesionsYoussriah Yahia Sabri0Eman Zaki Bassyouni Nossair1HebatAllah Hany Assal2Hisham Samir Wahba3Radiodiagnosis, Faculty of Medicine, Cairo UniversityRadiodiagnosis, National Hepatology and Tropical Medicine Research Institute (NHTMRI)Pulmonology, Faculty of Medicine, Cairo UniversityRadiodiagnosis, National Cancer Institute, Cairo UniversityAbstract Background Conducted studies showed that the ADC (apparent diffusion coefficient) values of malignant mediastinal lesions are significantly lower than those of benign lesions. Investigators determined cut-off ADC values to differentiate the two; concluding that ADC value is a promising noninvasive, imaging parameter that helps assess and characterize mediastinal tumors. Taking this a step forward, the primary objective of our prospective study was to investigate the potential of DW-MRI (diffusion-weighted magnetic resonance imaging) to characterize malignant mediastinal lesions using their ADC values. Thirty-three patients that underwent MRI of the chest with DWI and latter pathologically diagnosed with a malignant mediastinal lesion were included in this study. Lesions’ ADC values were measured and correlated with the histopathological results. The statistical significance of differences between measurements was tested using the one-way ANOVA (analysis of variance) test; p values equal to or less than 0.05 were considered significant. Results There was no statistically significant difference between the ADCmean values of the histopathological groups of lesions assessed with the overlap of their ADCmean values. The average ADCmean value of NHL (non-Hodgkin lymphoma) was evidently lower than that of HD (Hodgkin disease) with no overlap between their ADCmean values. DWI failed at characterizing one lesion in this study as a malignant tumor, namely an immature teratoma (germ-cell tumor). Again DWI could not be used to evaluate a mass, latter pathologically diagnosed as an angiosarcoma, because of its overall hemorrhagic nature showing no definite non-hemorrhagic soft tissue components. The aforementioned results did not differ considerably when minimum ADC was used instead of mean ADC. Conclusion There was no statistically significant difference between the ADC values of the malignant mediastinal lesions evaluated. However, regarding lymphoma subtypes, our limited sample study of lymphoma suggested a considerable difference between the ADC values of Hodgkin disease and non-Hodgkin lymphoma.https://doi.org/10.1186/s43055-020-0132-6Malignant mediastinal lesionsDWI (diffusion-weighted imaging)ADC (apparent diffusion coefficient) |
| spellingShingle | Youssriah Yahia Sabri Eman Zaki Bassyouni Nossair HebatAllah Hany Assal Hisham Samir Wahba Role of diffusion weighted MR-imaging in the evaluation of malignant mediastinal lesions The Egyptian Journal of Radiology and Nuclear Medicine Malignant mediastinal lesions DWI (diffusion-weighted imaging) ADC (apparent diffusion coefficient) |
| title | Role of diffusion weighted MR-imaging in the evaluation of malignant mediastinal lesions |
| title_full | Role of diffusion weighted MR-imaging in the evaluation of malignant mediastinal lesions |
| title_fullStr | Role of diffusion weighted MR-imaging in the evaluation of malignant mediastinal lesions |
| title_full_unstemmed | Role of diffusion weighted MR-imaging in the evaluation of malignant mediastinal lesions |
| title_short | Role of diffusion weighted MR-imaging in the evaluation of malignant mediastinal lesions |
| title_sort | role of diffusion weighted mr imaging in the evaluation of malignant mediastinal lesions |
| topic | Malignant mediastinal lesions DWI (diffusion-weighted imaging) ADC (apparent diffusion coefficient) |
| url | https://doi.org/10.1186/s43055-020-0132-6 |
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