1,3,4-Oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole derivatives as potential antibacterial agents
Since the introduction of the first antibiotic (penicillin, 1942) into medical practice, to date, there has been an ongoing “race” between scientists creating new drugs and pathogenic bacteria. Antibiotic-bacteria are becoming progressively common, and to make matters worse, more and more bacteria a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-11-01
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| Series: | Arabian Journal of Chemistry |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535214002032 |
| _version_ | 1818303785147039744 |
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| author | Adil A. Othman Mebrouk Kihel Sarah Amara |
| author_facet | Adil A. Othman Mebrouk Kihel Sarah Amara |
| author_sort | Adil A. Othman |
| collection | DOAJ |
| description | Since the introduction of the first antibiotic (penicillin, 1942) into medical practice, to date, there has been an ongoing “race” between scientists creating new drugs and pathogenic bacteria. Antibiotic-bacteria are becoming progressively common, and to make matters worse, more and more bacteria are becoming resistant to all known antibiotics. The traditional method for this problem is to introduce new antibiotics that kill the resistant mutants. This specific “arms race” resulted into thousands of potentially active chemicals are synthesized in laboratories around the world every day.1,3,4-Oxadiazole; 1,3,4-thiadiazole; 1,2,4-triazole and some of their derivatives are involved in modifications at the following axes: First, attaching a thio-group into heterocyclic rings. Second, introducing different substitutions at position 5 which often are the residuals of the synthetic starting materials such as simple aliphatic, substituted aliphatic chains, aromatic carbocyclic and heterocyclic residues. Keywords: Mercapto-1,3,4-oxadiazole, 1,3,4-Thiadiazole, 1,2,4-Triazole, Antibacterial agents |
| first_indexed | 2024-12-13T06:00:19Z |
| format | Article |
| id | doaj.art-add2d355ab5d42669ca05810546b7a43 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-13T06:00:19Z |
| publishDate | 2019-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-add2d355ab5d42669ca05810546b7a432022-12-21T23:57:22ZengElsevierArabian Journal of Chemistry1878-53522019-11-01127166016751,3,4-Oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole derivatives as potential antibacterial agentsAdil A. Othman0Mebrouk Kihel1Sarah Amara2Department of Chemistry, Faculty of Sciences, University of Sciences and Technology of Oran-Mohamed Boudiaf – USTO-MB, B.P.1505 El-M’naouer, Oran 31000, Algeria; Corresponding author.Department of Biology, Faculty of Sciences, University of Oran, Es-Senia, Oran, AlgeriaDepartment of Chemistry, Faculty of Sciences, University of Sciences and Technology of Oran-Mohamed Boudiaf – USTO-MB, B.P.1505 El-M’naouer, Oran 31000, AlgeriaSince the introduction of the first antibiotic (penicillin, 1942) into medical practice, to date, there has been an ongoing “race” between scientists creating new drugs and pathogenic bacteria. Antibiotic-bacteria are becoming progressively common, and to make matters worse, more and more bacteria are becoming resistant to all known antibiotics. The traditional method for this problem is to introduce new antibiotics that kill the resistant mutants. This specific “arms race” resulted into thousands of potentially active chemicals are synthesized in laboratories around the world every day.1,3,4-Oxadiazole; 1,3,4-thiadiazole; 1,2,4-triazole and some of their derivatives are involved in modifications at the following axes: First, attaching a thio-group into heterocyclic rings. Second, introducing different substitutions at position 5 which often are the residuals of the synthetic starting materials such as simple aliphatic, substituted aliphatic chains, aromatic carbocyclic and heterocyclic residues. Keywords: Mercapto-1,3,4-oxadiazole, 1,3,4-Thiadiazole, 1,2,4-Triazole, Antibacterial agentshttp://www.sciencedirect.com/science/article/pii/S1878535214002032 |
| spellingShingle | Adil A. Othman Mebrouk Kihel Sarah Amara 1,3,4-Oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole derivatives as potential antibacterial agents Arabian Journal of Chemistry |
| title | 1,3,4-Oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole derivatives as potential antibacterial agents |
| title_full | 1,3,4-Oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole derivatives as potential antibacterial agents |
| title_fullStr | 1,3,4-Oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole derivatives as potential antibacterial agents |
| title_full_unstemmed | 1,3,4-Oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole derivatives as potential antibacterial agents |
| title_short | 1,3,4-Oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole derivatives as potential antibacterial agents |
| title_sort | 1 3 4 oxadiazole 1 3 4 thiadiazole and 1 2 4 triazole derivatives as potential antibacterial agents |
| url | http://www.sciencedirect.com/science/article/pii/S1878535214002032 |
| work_keys_str_mv | AT adilaothman 134oxadiazole134thiadiazoleand124triazolederivativesaspotentialantibacterialagents AT mebroukkihel 134oxadiazole134thiadiazoleand124triazolederivativesaspotentialantibacterialagents AT sarahamara 134oxadiazole134thiadiazoleand124triazolederivativesaspotentialantibacterialagents |