Actualities in the Morphology and Immunohistochemistry of Cutaneous and Ocular Melanoma: What Lies Ahead? A Single-Centre Study
Melanoma is the most aggressive melanocytic tumor whose incidence is continuously increasing worldwide. Methods: We highlight the morphological, immunohistochemistry, and particularities of various melanoma types based on the cases diagnosed in our department from 2017 to 2021. Results: We present 1...
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2022-10-01
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| author | Andreea Cătălina Tinca Raluca Moraru Iuliu Gabriel Cocuz Mihaela Cornelia Șincu Raluca Niculescu Adrian Horațiu Sabău Diana Maria Chiorean Andreea Raluca Szoke Silviu-Horia Morariu Ovidiu Simion Cotoi |
| author_facet | Andreea Cătălina Tinca Raluca Moraru Iuliu Gabriel Cocuz Mihaela Cornelia Șincu Raluca Niculescu Adrian Horațiu Sabău Diana Maria Chiorean Andreea Raluca Szoke Silviu-Horia Morariu Ovidiu Simion Cotoi |
| author_sort | Andreea Cătălina Tinca |
| collection | DOAJ |
| description | Melanoma is the most aggressive melanocytic tumor whose incidence is continuously increasing worldwide. Methods: We highlight the morphological, immunohistochemistry, and particularities of various melanoma types based on the cases diagnosed in our department from 2017 to 2021. Results: We present 100 melanoma cases and one capsular nevus case. The most common type was nodular melanoma. The immunohistochemistry markers used were SRY-box transcription factor 10 (SOX10), S100 protein, human melanoma black 45 (HMB45), and melanoma antigen recognized by T cells 1 (Melan-A). Uveal melanoma and conjunctival melanoma represent particular tumors with independent prognostic factors. Uveal melanoma requires assessment of macrophages, microvascularisation, and mitoses. Sentinel lymph node metastases are essential targets that provide staging tools. Conjunctival melanoma and capsular nevi are diagnostic pitfalls. Conclusion: Melanoma can appear in various forms, and sometimes the diagnosis might be unclear. Today, immunohistochemistry remains the most important tool in confirming the diagnosis and prognosis for this type of neoplasia. |
| first_indexed | 2024-03-09T20:39:12Z |
| format | Article |
| id | doaj.art-add33af740d6454b838f61acad7063ce |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:39:12Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-add33af740d6454b838f61acad7063ce2023-11-23T23:04:10ZengMDPI AGBiomedicines2227-90592022-10-011010250010.3390/biomedicines10102500Actualities in the Morphology and Immunohistochemistry of Cutaneous and Ocular Melanoma: What Lies Ahead? A Single-Centre StudyAndreea Cătălina Tinca0Raluca Moraru1Iuliu Gabriel Cocuz2Mihaela Cornelia Șincu3Raluca Niculescu4Adrian Horațiu Sabău5Diana Maria Chiorean6Andreea Raluca Szoke7Silviu-Horia Morariu8Ovidiu Simion Cotoi9Doctoral School of Medicine and Pharmacy, University of Medicine, Pharmacy, Sciences and Technology “George Emil Palade” of Targu Mures, 540142 Targu Mures, RomaniaDepartment of Plastic Surgery, Mureș Clinical County Hospital, 540011 Targu Mures, RomaniaDoctoral School of Medicine and Pharmacy, University of Medicine, Pharmacy, Sciences and Technology “George Emil Palade” of Targu Mures, 540142 Targu Mures, RomaniaDoctoral School of Medicine and Pharmacy, University of Medicine, Pharmacy, Sciences and Technology “George Emil Palade” of Targu Mures, 540142 Targu Mures, RomaniaDoctoral School of Medicine and Pharmacy, University of Medicine, Pharmacy, Sciences and Technology “George Emil Palade” of Targu Mures, 540142 Targu Mures, RomaniaDoctoral School of Medicine and Pharmacy, University of Medicine, Pharmacy, Sciences and Technology “George Emil Palade” of Targu Mures, 540142 Targu Mures, RomaniaDoctoral School of Medicine and Pharmacy, University of Medicine, Pharmacy, Sciences and Technology “George Emil Palade” of Targu Mures, 540142 Targu Mures, RomaniaDoctoral School of Medicine and Pharmacy, University of Medicine, Pharmacy, Sciences and Technology “George Emil Palade” of Targu Mures, 540142 Targu Mures, RomaniaDermatology Department, University of Medicine, Pharmacy, Sciences and Technology “George Emil Palade” of Targu Mures, 540142 Targu Mures, RomaniaPathology Department, Mures Clinical County Hospital, 540011 Targu Mures, RomaniaMelanoma is the most aggressive melanocytic tumor whose incidence is continuously increasing worldwide. Methods: We highlight the morphological, immunohistochemistry, and particularities of various melanoma types based on the cases diagnosed in our department from 2017 to 2021. Results: We present 100 melanoma cases and one capsular nevus case. The most common type was nodular melanoma. The immunohistochemistry markers used were SRY-box transcription factor 10 (SOX10), S100 protein, human melanoma black 45 (HMB45), and melanoma antigen recognized by T cells 1 (Melan-A). Uveal melanoma and conjunctival melanoma represent particular tumors with independent prognostic factors. Uveal melanoma requires assessment of macrophages, microvascularisation, and mitoses. Sentinel lymph node metastases are essential targets that provide staging tools. Conjunctival melanoma and capsular nevi are diagnostic pitfalls. Conclusion: Melanoma can appear in various forms, and sometimes the diagnosis might be unclear. Today, immunohistochemistry remains the most important tool in confirming the diagnosis and prognosis for this type of neoplasia.https://www.mdpi.com/2227-9059/10/10/2500melanomaimmunohistochemistryBRAFmetastasessentinel lymph nodes |
| spellingShingle | Andreea Cătălina Tinca Raluca Moraru Iuliu Gabriel Cocuz Mihaela Cornelia Șincu Raluca Niculescu Adrian Horațiu Sabău Diana Maria Chiorean Andreea Raluca Szoke Silviu-Horia Morariu Ovidiu Simion Cotoi Actualities in the Morphology and Immunohistochemistry of Cutaneous and Ocular Melanoma: What Lies Ahead? A Single-Centre Study Biomedicines melanoma immunohistochemistry BRAF metastases sentinel lymph nodes |
| title | Actualities in the Morphology and Immunohistochemistry of Cutaneous and Ocular Melanoma: What Lies Ahead? A Single-Centre Study |
| title_full | Actualities in the Morphology and Immunohistochemistry of Cutaneous and Ocular Melanoma: What Lies Ahead? A Single-Centre Study |
| title_fullStr | Actualities in the Morphology and Immunohistochemistry of Cutaneous and Ocular Melanoma: What Lies Ahead? A Single-Centre Study |
| title_full_unstemmed | Actualities in the Morphology and Immunohistochemistry of Cutaneous and Ocular Melanoma: What Lies Ahead? A Single-Centre Study |
| title_short | Actualities in the Morphology and Immunohistochemistry of Cutaneous and Ocular Melanoma: What Lies Ahead? A Single-Centre Study |
| title_sort | actualities in the morphology and immunohistochemistry of cutaneous and ocular melanoma what lies ahead a single centre study |
| topic | melanoma immunohistochemistry BRAF metastases sentinel lymph nodes |
| url | https://www.mdpi.com/2227-9059/10/10/2500 |
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