Lawsonia inermis possesses a significant analgesic activity compared to Waltheria indica, Moringa oleifera, Nigella sativa, and diclofenac in female Wistar rats
Pain is a severe symptom of many diseases, with an increasing percentage of people manifesting various types of pain. Medicinal plants provide analgesic potential with little toxicity. We performed this experiment to compare the analgesic activities of Lawsonia inermis, Waltheria indica, Moringa ole...
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Ferdowsi University of Mashhad
2023-07-01
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| Series: | The Iranian Journal of Veterinary Science and Technology |
| Subjects: | |
| Online Access: | https://ijvst.um.ac.ir/article_43937_88ac3e9633aebb0b12207b088b6d18d7.pdf |
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| author | Abdulfatai Aremu Jiddah Idris Ganiu Akorede Aishat Olatumji Afisu Basiru Akeem Ahmed |
| author_facet | Abdulfatai Aremu Jiddah Idris Ganiu Akorede Aishat Olatumji Afisu Basiru Akeem Ahmed |
| author_sort | Abdulfatai Aremu |
| collection | DOAJ |
| description | Pain is a severe symptom of many diseases, with an increasing percentage of people manifesting various types of pain. Medicinal plants provide analgesic potential with little toxicity. We performed this experiment to compare the analgesic activities of Lawsonia inermis, Waltheria indica, Moringa oleifera, and Nigella sativa in Wistar rats using writhing and paw lick responses. We grouped 21 adult female rats into seven groups (n=3), including uninduced and untreated rats (group 1), induced untreated rats (group 2), rats treated with Lawsonia inermis at 200 mg/kg (group 3), rats treated with Waltheria indica at 200 mg/kg (group 4), rats treated with Nigella sativa at 200 mg/kg (group 5), rats treated with Moringa oleifera at 200 mg/kg (group 6), and rats treated with diclofenac at 10 mg/kg (group 7). We dosed rats for 14 days after inducing the pain. Phytochemical screening showed that methanolic extracts of Lawsonia inermis, Moringa oleifera, and ethanolic extract of Waltheria indica contain: Alkaloid, saponin, steroid, tannin, flavonoid, phenols, terpene, and glycosides. The rate of weight gain in rats treated with M. oleifera and W. indica was 7%, and with diclofenac was 9% compared to the untreated control. L. inermis and N. sativa possessed a weight gain of 3% and 2%, respectively. All the extracts exhibited analgesic activities by significantly reducing the number of lick and writh in the order of Lawsonia inermis, Nigella sativa, Moringa oleifera, and Waltheria indica.This study concluded that Lawsonia inermis possess significant analgesic activities compared to other plants and the standard drug (diclofenac). |
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| format | Article |
| id | doaj.art-add42258a16f44e29f9726411a17e4b6 |
| institution | Directory Open Access Journal |
| issn | 2008-465X 2423-6306 |
| language | English |
| last_indexed | 2024-03-12T21:01:17Z |
| publishDate | 2023-07-01 |
| publisher | Ferdowsi University of Mashhad |
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| series | The Iranian Journal of Veterinary Science and Technology |
| spelling | doaj.art-add42258a16f44e29f9726411a17e4b62023-07-31T07:41:17ZengFerdowsi University of MashhadThe Iranian Journal of Veterinary Science and Technology2008-465X2423-63062023-07-01152485510.22067/ijvst.2023.80490.121943937Lawsonia inermis possesses a significant analgesic activity compared to Waltheria indica, Moringa oleifera, Nigella sativa, and diclofenac in female Wistar ratsAbdulfatai Aremu0Jiddah Idris1Ganiu Akorede2Aishat Olatumji3Afisu Basiru4Akeem Ahmed5Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria.Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria.Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria.Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria.Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria.Department of Veterinary Microbiology, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria.Pain is a severe symptom of many diseases, with an increasing percentage of people manifesting various types of pain. Medicinal plants provide analgesic potential with little toxicity. We performed this experiment to compare the analgesic activities of Lawsonia inermis, Waltheria indica, Moringa oleifera, and Nigella sativa in Wistar rats using writhing and paw lick responses. We grouped 21 adult female rats into seven groups (n=3), including uninduced and untreated rats (group 1), induced untreated rats (group 2), rats treated with Lawsonia inermis at 200 mg/kg (group 3), rats treated with Waltheria indica at 200 mg/kg (group 4), rats treated with Nigella sativa at 200 mg/kg (group 5), rats treated with Moringa oleifera at 200 mg/kg (group 6), and rats treated with diclofenac at 10 mg/kg (group 7). We dosed rats for 14 days after inducing the pain. Phytochemical screening showed that methanolic extracts of Lawsonia inermis, Moringa oleifera, and ethanolic extract of Waltheria indica contain: Alkaloid, saponin, steroid, tannin, flavonoid, phenols, terpene, and glycosides. The rate of weight gain in rats treated with M. oleifera and W. indica was 7%, and with diclofenac was 9% compared to the untreated control. L. inermis and N. sativa possessed a weight gain of 3% and 2%, respectively. All the extracts exhibited analgesic activities by significantly reducing the number of lick and writh in the order of Lawsonia inermis, Nigella sativa, Moringa oleifera, and Waltheria indica.This study concluded that Lawsonia inermis possess significant analgesic activities compared to other plants and the standard drug (diclofenac).https://ijvst.um.ac.ir/article_43937_88ac3e9633aebb0b12207b088b6d18d7.pdfpainlawsonia inermisnigella sativamoringa oleiferawaltheria indicaanalgesic |
| spellingShingle | Abdulfatai Aremu Jiddah Idris Ganiu Akorede Aishat Olatumji Afisu Basiru Akeem Ahmed Lawsonia inermis possesses a significant analgesic activity compared to Waltheria indica, Moringa oleifera, Nigella sativa, and diclofenac in female Wistar rats The Iranian Journal of Veterinary Science and Technology pain lawsonia inermis nigella sativa moringa oleifera waltheria indica analgesic |
| title | Lawsonia inermis possesses a significant analgesic activity compared to Waltheria indica, Moringa oleifera, Nigella sativa, and diclofenac in female Wistar rats |
| title_full | Lawsonia inermis possesses a significant analgesic activity compared to Waltheria indica, Moringa oleifera, Nigella sativa, and diclofenac in female Wistar rats |
| title_fullStr | Lawsonia inermis possesses a significant analgesic activity compared to Waltheria indica, Moringa oleifera, Nigella sativa, and diclofenac in female Wistar rats |
| title_full_unstemmed | Lawsonia inermis possesses a significant analgesic activity compared to Waltheria indica, Moringa oleifera, Nigella sativa, and diclofenac in female Wistar rats |
| title_short | Lawsonia inermis possesses a significant analgesic activity compared to Waltheria indica, Moringa oleifera, Nigella sativa, and diclofenac in female Wistar rats |
| title_sort | lawsonia inermis possesses a significant analgesic activity compared to waltheria indica moringa oleifera nigella sativa and diclofenac in female wistar rats |
| topic | pain lawsonia inermis nigella sativa moringa oleifera waltheria indica analgesic |
| url | https://ijvst.um.ac.ir/article_43937_88ac3e9633aebb0b12207b088b6d18d7.pdf |
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