GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives
Background: Malignant melanoma is the most aggressive of skin cancers and the 19th most common cancer worldwide, with an estimated age-standardized incidence rate of 2.8–3.1 per 100,000; although there have been clear advances in therapeutic treatment, the prognosis of MM patients with Breslow thick...
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MDPI AG
2021-11-01
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| Online Access: | https://www.mdpi.com/2073-4409/10/11/3090 |
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| author | Gerardo Cazzato Anna Colagrande Antonietta Cimmino Caterina Abbatepaolo Emilio Bellitti Paolo Romita Lucia Lospalluti Caterina Foti Francesca Arezzo Vera Loizzi Teresa Lettini Sara Sablone Leonardo Resta Gennaro Cormio Giuseppe Ingravallo Roberta Rossi |
| author_facet | Gerardo Cazzato Anna Colagrande Antonietta Cimmino Caterina Abbatepaolo Emilio Bellitti Paolo Romita Lucia Lospalluti Caterina Foti Francesca Arezzo Vera Loizzi Teresa Lettini Sara Sablone Leonardo Resta Gennaro Cormio Giuseppe Ingravallo Roberta Rossi |
| author_sort | Gerardo Cazzato |
| collection | DOAJ |
| description | Background: Malignant melanoma is the most aggressive of skin cancers and the 19th most common cancer worldwide, with an estimated age-standardized incidence rate of 2.8–3.1 per 100,000; although there have been clear advances in therapeutic treatment, the prognosis of MM patients with Breslow thickness greater than 1 mm is still quite poor today. The study of how melanoma cells manage to survive and proliferate by consuming glucose has been partially addressed in the literature, but some rather interesting results are starting to be present. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and a search of PubMed and Web of Sciences (WoS) databases was performed until 27 September 2021 using the terms: glucose transporter 1 and 3 and GLUT1/3 in combination with each of the following: melanoma, neoplasm and immunohistochemistry. Results: In total, 46 records were initially identified in the literature search, of which six were duplicates. After screening for eligibility and inclusion criteria, 16 publications were ultimately included. Conclusions: the results discussed regarding the role and expression of GLUT are still far from definitive, but further steps toward understanding and stopping this mechanism have, at least in part, been taken. New studies and new discoveries should lead to further clarification of some aspects since the various mechanisms of glucose uptake by neoplastic cells are not limited to the transporters of the GLUT family alone. |
| first_indexed | 2024-03-10T05:36:35Z |
| format | Article |
| id | doaj.art-add43add2b6a4482a075cc3b0644852e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T05:36:35Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-add43add2b6a4482a075cc3b0644852e2023-11-22T22:51:09ZengMDPI AGCells2073-44092021-11-011011309010.3390/cells10113090GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and PerspectivesGerardo Cazzato0Anna Colagrande1Antonietta Cimmino2Caterina Abbatepaolo3Emilio Bellitti4Paolo Romita5Lucia Lospalluti6Caterina Foti7Francesca Arezzo8Vera Loizzi9Teresa Lettini10Sara Sablone11Leonardo Resta12Gennaro Cormio13Giuseppe Ingravallo14Roberta Rossi15Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari, “Aldo Moro”, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari, “Aldo Moro”, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari, “Aldo Moro”, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari, “Aldo Moro”, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari, “Aldo Moro”, 70124 Bari, ItalySection of Dermatology, Department of Biomedical Sciences and Human Oncology, University of Bari, “Aldo Moro”, 70124 Bari, ItalySection of Dermatology, Department of Biomedical Sciences and Human Oncology, University of Bari, “Aldo Moro”, 70124 Bari, ItalySection of Dermatology, Department of Biomedical Sciences and Human Oncology, University of Bari, “Aldo Moro”, 70124 Bari, ItalySection of Ginecology and Obstetrics, Department of Biomedical Sciences and Human Oncology, University of Bari, “Aldo Moro”, 70124 Bari, ItalySection of Ginecology and Obstetrics, Department of Biomedical Sciences and Human Oncology, University of Bari, “Aldo Moro”, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari, “Aldo Moro”, 70124 Bari, ItalySection of Legal Medicine, Department of Interdisciplinary Medicine, Bari Policlinico Hospital, University of Bari, “Aldo Moro”, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari, “Aldo Moro”, 70124 Bari, ItalySection of Ginecology and Obstetrics, Department of Biomedical Sciences and Human Oncology, University of Bari, “Aldo Moro”, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari, “Aldo Moro”, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari, “Aldo Moro”, 70124 Bari, ItalyBackground: Malignant melanoma is the most aggressive of skin cancers and the 19th most common cancer worldwide, with an estimated age-standardized incidence rate of 2.8–3.1 per 100,000; although there have been clear advances in therapeutic treatment, the prognosis of MM patients with Breslow thickness greater than 1 mm is still quite poor today. The study of how melanoma cells manage to survive and proliferate by consuming glucose has been partially addressed in the literature, but some rather interesting results are starting to be present. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and a search of PubMed and Web of Sciences (WoS) databases was performed until 27 September 2021 using the terms: glucose transporter 1 and 3 and GLUT1/3 in combination with each of the following: melanoma, neoplasm and immunohistochemistry. Results: In total, 46 records were initially identified in the literature search, of which six were duplicates. After screening for eligibility and inclusion criteria, 16 publications were ultimately included. Conclusions: the results discussed regarding the role and expression of GLUT are still far from definitive, but further steps toward understanding and stopping this mechanism have, at least in part, been taken. New studies and new discoveries should lead to further clarification of some aspects since the various mechanisms of glucose uptake by neoplastic cells are not limited to the transporters of the GLUT family alone.https://www.mdpi.com/2073-4409/10/11/3090GLUT1GLUT3malignant melanomaimmunohistochemistryperspectives |
| spellingShingle | Gerardo Cazzato Anna Colagrande Antonietta Cimmino Caterina Abbatepaolo Emilio Bellitti Paolo Romita Lucia Lospalluti Caterina Foti Francesca Arezzo Vera Loizzi Teresa Lettini Sara Sablone Leonardo Resta Gennaro Cormio Giuseppe Ingravallo Roberta Rossi GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives Cells GLUT1 GLUT3 malignant melanoma immunohistochemistry perspectives |
| title | GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives |
| title_full | GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives |
| title_fullStr | GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives |
| title_full_unstemmed | GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives |
| title_short | GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives |
| title_sort | glut1 glut3 expression and 18fdg pet ct in human malignant melanoma what relationship exists new insights and perspectives |
| topic | GLUT1 GLUT3 malignant melanoma immunohistochemistry perspectives |
| url | https://www.mdpi.com/2073-4409/10/11/3090 |
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