Suppressive effects of plumbagin on the growth of human bladder cancer cells via PI3K/AKT/mTOR signaling pathways and EMT

Suppressive effects of plumbagin on the growth of human bladder cancer cells via PI3K/AKT/mTOR signaling pathways and EMT

Abstract Background Novel chemotherapeutic drugs with good anti-tumor activity are of pressing need for bladder cancer treatment. In this study, plumbagin (PL), a natural plant-derived drug extracted from Chinese herbals, was identified as a promising candidate for human bladder cancer (BCa) chemoth...

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Bibliographic Details
Main Authors: Renjie Zhang, Zijian Wang, Wenjie You, Fengfang Zhou, Zicheng Guo, Kaiyu Qian, Yu Xiao, Xinghuan Wang
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Cancer Cell International
Subjects:
Plumbagin
Bladder cancer
PI3K/AKT/mTOR
Cell cycle
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12935-020-01607-y

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