Differences in gene mutations according to gender among patients with colorectal cancer
Abstract Background The incidence, site distribution, and mortality rates of patients with colorectal cancer differ according to gender. We investigated gene mutations in colorectal patients and wanted to examine gender-specific differences. Methods A total of 1505 patients who underwent surgical in...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-07-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12957-018-1431-5 |
| _version_ | 1818864448023035904 |
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| author | Yi-Jian Tsai Sheng-Chieh Huang Hung-Hsin Lin Chun-Chi Lin Yuan-Tzu Lan Huann-Sheng Wang Shung-Haur Yang Jeng-Kai Jiang Wei-Shone Chen Tzu-chen Lin Jen-Kou Lin Shih-Ching Chang |
| author_facet | Yi-Jian Tsai Sheng-Chieh Huang Hung-Hsin Lin Chun-Chi Lin Yuan-Tzu Lan Huann-Sheng Wang Shung-Haur Yang Jeng-Kai Jiang Wei-Shone Chen Tzu-chen Lin Jen-Kou Lin Shih-Ching Chang |
| author_sort | Yi-Jian Tsai |
| collection | DOAJ |
| description | Abstract Background The incidence, site distribution, and mortality rates of patients with colorectal cancer differ according to gender. We investigated gene mutations in colorectal patients and wanted to examine gender-specific differences. Methods A total of 1505 patients who underwent surgical intervention for colorectal cancer were recruited from March 2000 to January 2010 at Taipei Veterans’ General Hospital and investigated for gene mutations in K-ras, N-ras, H-ras, BRAF, loss of 18q, APC, p53, SMAD4, TGF-β, PIK3CA, PTEN, FBXW7, AKT1, and MSI. Results There were significant differences between male and female patients in terms of tumor location (p < 0.0001) and pathological stage (p = 0.011). The female patients had significantly more gene mutations in BRAF (6.4 vs. 3.3%, OR 1.985, p = 0.006), TGF-β (4.7 vs. 2.5%, OR 1.887, p = 0.027), and revealed a MSI-high status (14.0 vs. 8.3%, OR 1.800, p = 0.001) than male patients. Male patients had significantly more gene mutations in N-ras (5.1 vs. 2.3%, OR 2.227, p = 0.012); however, the significance was maintained only for mutations in BRAF (OR 2.104, p = 0.038), MSI-high status (OR 2.003 p = 0.001), and N-ras (OR 3.000, p = 0.010) after the groups were divided by tumor site. Conclusion Gene mutations in BRAF, MSI-high status, and N-ras differ according to gender among patients with colorectal cancer. |
| first_indexed | 2024-12-19T10:31:49Z |
| format | Article |
| id | doaj.art-add6b535ade741f3bf71e82467e720f5 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-19T10:31:49Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-add6b535ade741f3bf71e82467e720f52022-12-21T20:25:44ZengBMCWorld Journal of Surgical Oncology1477-78192018-07-011611510.1186/s12957-018-1431-5Differences in gene mutations according to gender among patients with colorectal cancerYi-Jian Tsai0Sheng-Chieh Huang1Hung-Hsin Lin2Chun-Chi Lin3Yuan-Tzu Lan4Huann-Sheng Wang5Shung-Haur Yang6Jeng-Kai Jiang7Wei-Shone Chen8Tzu-chen Lin9Jen-Kou Lin10Shih-Ching Chang11Division of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General HospitalDivision of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General HospitalDivision of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General HospitalDivision of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General HospitalDivision of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General HospitalDivision of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General HospitalDivision of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General HospitalDivision of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General HospitalDivision of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General HospitalDivision of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General HospitalDivision of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General HospitalDivision of Colon and Rectal Surgery, Department of Surgery, Taipei-Veterans General HospitalAbstract Background The incidence, site distribution, and mortality rates of patients with colorectal cancer differ according to gender. We investigated gene mutations in colorectal patients and wanted to examine gender-specific differences. Methods A total of 1505 patients who underwent surgical intervention for colorectal cancer were recruited from March 2000 to January 2010 at Taipei Veterans’ General Hospital and investigated for gene mutations in K-ras, N-ras, H-ras, BRAF, loss of 18q, APC, p53, SMAD4, TGF-β, PIK3CA, PTEN, FBXW7, AKT1, and MSI. Results There were significant differences between male and female patients in terms of tumor location (p < 0.0001) and pathological stage (p = 0.011). The female patients had significantly more gene mutations in BRAF (6.4 vs. 3.3%, OR 1.985, p = 0.006), TGF-β (4.7 vs. 2.5%, OR 1.887, p = 0.027), and revealed a MSI-high status (14.0 vs. 8.3%, OR 1.800, p = 0.001) than male patients. Male patients had significantly more gene mutations in N-ras (5.1 vs. 2.3%, OR 2.227, p = 0.012); however, the significance was maintained only for mutations in BRAF (OR 2.104, p = 0.038), MSI-high status (OR 2.003 p = 0.001), and N-ras (OR 3.000, p = 0.010) after the groups were divided by tumor site. Conclusion Gene mutations in BRAF, MSI-high status, and N-ras differ according to gender among patients with colorectal cancer.http://link.springer.com/article/10.1186/s12957-018-1431-5Colorectal cancerGenderGene mutation |
| spellingShingle | Yi-Jian Tsai Sheng-Chieh Huang Hung-Hsin Lin Chun-Chi Lin Yuan-Tzu Lan Huann-Sheng Wang Shung-Haur Yang Jeng-Kai Jiang Wei-Shone Chen Tzu-chen Lin Jen-Kou Lin Shih-Ching Chang Differences in gene mutations according to gender among patients with colorectal cancer World Journal of Surgical Oncology Colorectal cancer Gender Gene mutation |
| title | Differences in gene mutations according to gender among patients with colorectal cancer |
| title_full | Differences in gene mutations according to gender among patients with colorectal cancer |
| title_fullStr | Differences in gene mutations according to gender among patients with colorectal cancer |
| title_full_unstemmed | Differences in gene mutations according to gender among patients with colorectal cancer |
| title_short | Differences in gene mutations according to gender among patients with colorectal cancer |
| title_sort | differences in gene mutations according to gender among patients with colorectal cancer |
| topic | Colorectal cancer Gender Gene mutation |
| url | http://link.springer.com/article/10.1186/s12957-018-1431-5 |
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