Tumor Extracellular Matrix Stiffness Promptly Modulates the Phenotype and Gene Expression of Infiltrating T Lymphocytes

Tumor Extracellular Matrix Stiffness Promptly Modulates the Phenotype and Gene Expression of Infiltrating T Lymphocytes

The immune system is a fine modulator of the tumor biology supporting or inhibiting its progression, growth, invasion and conveys the pharmacological treatment effect. Tumors, on their side, have developed escaping mechanisms from the immune system action ranging from the direct secretion of biochem...

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Bibliographic Details
Main Authors: Maila Chirivì, Fabio Maiullari, Marika Milan, Dario Presutti, Chiara Cordiglieri, Mariacristina Crosti, Maria Lucia Sarnicola, Andrea Soluri, Marina Volpi, Wojciech Święszkowski, Daniele Prati, Marta Rizzi, Marco Costantini, Dror Seliktar, Chiara Parisi, Claudia Bearzi, Roberto Rizzi
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
tumor microenvironment
extracellular matrix
T lymphocytes
3D culture
Online Access:https://www.mdpi.com/1422-0067/22/11/5862

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