A peptide encoded by a highly conserved gene belonging to the genus Streptomyces shows antimicrobial activity against plant pathogens
The genus Streptomyces has been unceasingly highlighted for the versatility and diversity of the antimicrobial agents they produce. Moreover, it is a heavily sequenced taxon in the phylum Actinobacteria. In this study, 47 sequence profiles were identified as proteins highly conserved within the genu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Plant Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpls.2023.1250906/full |
| _version_ | 1797665824548323328 |
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| author | Byeong Jun Jeon Nayeon Yoo Jeong Do Kim Jaeyoung Choi |
| author_facet | Byeong Jun Jeon Nayeon Yoo Jeong Do Kim Jaeyoung Choi |
| author_sort | Byeong Jun Jeon |
| collection | DOAJ |
| description | The genus Streptomyces has been unceasingly highlighted for the versatility and diversity of the antimicrobial agents they produce. Moreover, it is a heavily sequenced taxon in the phylum Actinobacteria. In this study, 47 sequence profiles were identified as proteins highly conserved within the genus Streptomyces. Significant hits to the 38 profiles were found in more than 2000 Streptomyces genomes, 11 of which were further conserved in more than 90% of Actinobacterial genomes analyzed. Only a few genes corresponding to these sequence profiles were functionally characterized, which play regulatory roles in the morphology and biosynthesis of antibiotics. Here a highly conserved sequence, namely, SHC-AMP (Streptomyces highly conserved antimicrobial peptide), which exhibited antimicrobial activity against bacterial and fungal plant pathogens, was reported. In particular, Arabidopsis thaliana was effectively protected against infection with Pseudomonas syringae pv. tomato DC3000 by treatment with this peptide. Results indicated the potential application of this peptide as an antimicrobial agent for control of plant diseases. Our results suggest putative target genes for controlling Streptomyces spp., including the one exhibiting antimicrobial activity against a wide range of phytopathogens. |
| first_indexed | 2024-03-11T19:49:38Z |
| format | Article |
| id | doaj.art-addab0c792d74825aee8c5be28f5fa42 |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-03-11T19:49:38Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-addab0c792d74825aee8c5be28f5fa422023-10-05T11:35:13ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2023-10-011410.3389/fpls.2023.12509061250906A peptide encoded by a highly conserved gene belonging to the genus Streptomyces shows antimicrobial activity against plant pathogensByeong Jun Jeon0Nayeon Yoo1Jeong Do Kim2Jaeyoung Choi3Smart Farm Research Center, Korea Institute of Science and Technology, Gangneung, Republic of KoreaDepartment of Plant Biotechnology, Korea University, Seoul, Republic of KoreaSmart Farm Research Center, Korea Institute of Science and Technology, Gangneung, Republic of KoreaDepartment of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University, Yongin, Republic of KoreaThe genus Streptomyces has been unceasingly highlighted for the versatility and diversity of the antimicrobial agents they produce. Moreover, it is a heavily sequenced taxon in the phylum Actinobacteria. In this study, 47 sequence profiles were identified as proteins highly conserved within the genus Streptomyces. Significant hits to the 38 profiles were found in more than 2000 Streptomyces genomes, 11 of which were further conserved in more than 90% of Actinobacterial genomes analyzed. Only a few genes corresponding to these sequence profiles were functionally characterized, which play regulatory roles in the morphology and biosynthesis of antibiotics. Here a highly conserved sequence, namely, SHC-AMP (Streptomyces highly conserved antimicrobial peptide), which exhibited antimicrobial activity against bacterial and fungal plant pathogens, was reported. In particular, Arabidopsis thaliana was effectively protected against infection with Pseudomonas syringae pv. tomato DC3000 by treatment with this peptide. Results indicated the potential application of this peptide as an antimicrobial agent for control of plant diseases. Our results suggest putative target genes for controlling Streptomyces spp., including the one exhibiting antimicrobial activity against a wide range of phytopathogens.https://www.frontiersin.org/articles/10.3389/fpls.2023.1250906/fullantimicrobial peptideStreptomycesplant pathogenhighly conserved sequenceantimicrobial activity |
| spellingShingle | Byeong Jun Jeon Nayeon Yoo Jeong Do Kim Jaeyoung Choi A peptide encoded by a highly conserved gene belonging to the genus Streptomyces shows antimicrobial activity against plant pathogens Frontiers in Plant Science antimicrobial peptide Streptomyces plant pathogen highly conserved sequence antimicrobial activity |
| title | A peptide encoded by a highly conserved gene belonging to the genus Streptomyces shows antimicrobial activity against plant pathogens |
| title_full | A peptide encoded by a highly conserved gene belonging to the genus Streptomyces shows antimicrobial activity against plant pathogens |
| title_fullStr | A peptide encoded by a highly conserved gene belonging to the genus Streptomyces shows antimicrobial activity against plant pathogens |
| title_full_unstemmed | A peptide encoded by a highly conserved gene belonging to the genus Streptomyces shows antimicrobial activity against plant pathogens |
| title_short | A peptide encoded by a highly conserved gene belonging to the genus Streptomyces shows antimicrobial activity against plant pathogens |
| title_sort | peptide encoded by a highly conserved gene belonging to the genus streptomyces shows antimicrobial activity against plant pathogens |
| topic | antimicrobial peptide Streptomyces plant pathogen highly conserved sequence antimicrobial activity |
| url | https://www.frontiersin.org/articles/10.3389/fpls.2023.1250906/full |
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