Respiratory Syncytial Virus (RSV) G Protein Vaccines With Central Conserved Domain Mutations Induce CX3C-CX3CR1 Blocking Antibodies

Respiratory Syncytial Virus (RSV) G Protein Vaccines With Central Conserved Domain Mutations Induce CX3C-CX3CR1 Blocking Antibodies

Respiratory syncytial virus (RSV) infection can cause bronchiolitis, pneumonia, morbidity, and some mortality, primarily in infants and the elderly, for which no vaccine is available. The RSV attachment (G) protein contains a central conserved domain (CCD) with a CX3C motif implicated in the inducti...

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Bibliographic Details
Main Authors: Harrison C. Bergeron, Jackelyn Murray, Ana M. Nuñez Castrejon, Rebecca M. DuBois, Ralph A. Tripp
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Viruses
Subjects:
respiratory syncytial virus
RSV
vaccine
G protein
G glycoprotein
antibodies
Online Access:https://www.mdpi.com/1999-4915/13/2/352

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