Multidimensional pan-cancer analysis of HSPA5 and its validation in the prognostic value of bladder cancer
Endoplasmic reticulum (ER) stress-related genes are closely related to the occurrence, development, and immunotherapy response of tumors. This study provides a comprehensive assessment of HSPA5 from a pan-cancer perspective using multi-omics data. We analyzed the function of HSPA5 in multiple tumor...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024032158 |
| _version_ | 1797224285743349760 |
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| author | YaXuan Wang Jinfeng Wang Yang Liu XiaoLin Wang MingHua Ren |
| author_facet | YaXuan Wang Jinfeng Wang Yang Liu XiaoLin Wang MingHua Ren |
| author_sort | YaXuan Wang |
| collection | DOAJ |
| description | Endoplasmic reticulum (ER) stress-related genes are closely related to the occurrence, development, and immunotherapy response of tumors. This study provides a comprehensive assessment of HSPA5 from a pan-cancer perspective using multi-omics data. We analyzed the function of HSPA5 in multiple tumor types using multiple databases. Finally, immunohistochemistry was used to examine the relationship between HSPA5 expression in tissue microarrays from 100 patients with bladder cancer and the prognosis of patients with bladder cancer. Using the TCGA database, we were able to determine that HSPA5 is significantly elevated in a number of common malignancies and is linked with a bad prognosis. Cox regression analysis showed that the high expression of HSPA5 was correlated with OS, progression free survival (PFS), disease free survival (DFS), and disease special survival (DSS) of adrenocortical carcinoma (ACC). In addition, we discovered significant disparities in HSPA5 methylation and phosphorylation levels between various malignancies and normal tissues. HSPA5 expression was significantly correlated with the levels of infiltrating cells and immune checkpoint genes. HSPA5 is highly expressed in bladder cancer and patients with high HSPA5 expression have a poor prognosis. Our study provides a basis for further understanding of the role of ER stress-related gene HSPA5 in different tumor genesis and development. HSPA5 has also been shown to be a prognostic biomarker for bladder cancer patients. |
| first_indexed | 2024-04-24T13:50:42Z |
| format | Article |
| id | doaj.art-addaf68848bf4cc8b135052cb2f2dd68 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T13:50:42Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-addaf68848bf4cc8b135052cb2f2dd682024-04-04T05:04:26ZengElsevierHeliyon2405-84402024-03-01106e27184Multidimensional pan-cancer analysis of HSPA5 and its validation in the prognostic value of bladder cancerYaXuan Wang0Jinfeng Wang1Yang Liu2XiaoLin Wang3MingHua Ren4Department of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, ChinaDepartment of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, ChinaDepartment of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, ChinaDepartment of Urology, Nantong Tumor Hospital, Nantong, 226361, China; Corresponding author.Department of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, ChinaEndoplasmic reticulum (ER) stress-related genes are closely related to the occurrence, development, and immunotherapy response of tumors. This study provides a comprehensive assessment of HSPA5 from a pan-cancer perspective using multi-omics data. We analyzed the function of HSPA5 in multiple tumor types using multiple databases. Finally, immunohistochemistry was used to examine the relationship between HSPA5 expression in tissue microarrays from 100 patients with bladder cancer and the prognosis of patients with bladder cancer. Using the TCGA database, we were able to determine that HSPA5 is significantly elevated in a number of common malignancies and is linked with a bad prognosis. Cox regression analysis showed that the high expression of HSPA5 was correlated with OS, progression free survival (PFS), disease free survival (DFS), and disease special survival (DSS) of adrenocortical carcinoma (ACC). In addition, we discovered significant disparities in HSPA5 methylation and phosphorylation levels between various malignancies and normal tissues. HSPA5 expression was significantly correlated with the levels of infiltrating cells and immune checkpoint genes. HSPA5 is highly expressed in bladder cancer and patients with high HSPA5 expression have a poor prognosis. Our study provides a basis for further understanding of the role of ER stress-related gene HSPA5 in different tumor genesis and development. HSPA5 has also been shown to be a prognostic biomarker for bladder cancer patients.http://www.sciencedirect.com/science/article/pii/S2405844024032158HSPA5ER stressPrognosisBLCA |
| spellingShingle | YaXuan Wang Jinfeng Wang Yang Liu XiaoLin Wang MingHua Ren Multidimensional pan-cancer analysis of HSPA5 and its validation in the prognostic value of bladder cancer Heliyon HSPA5 ER stress Prognosis BLCA |
| title | Multidimensional pan-cancer analysis of HSPA5 and its validation in the prognostic value of bladder cancer |
| title_full | Multidimensional pan-cancer analysis of HSPA5 and its validation in the prognostic value of bladder cancer |
| title_fullStr | Multidimensional pan-cancer analysis of HSPA5 and its validation in the prognostic value of bladder cancer |
| title_full_unstemmed | Multidimensional pan-cancer analysis of HSPA5 and its validation in the prognostic value of bladder cancer |
| title_short | Multidimensional pan-cancer analysis of HSPA5 and its validation in the prognostic value of bladder cancer |
| title_sort | multidimensional pan cancer analysis of hspa5 and its validation in the prognostic value of bladder cancer |
| topic | HSPA5 ER stress Prognosis BLCA |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024032158 |
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