Immunotherapy and Immune Evasion in Prostate Cancer
Metastatic prostate cancer remains to this day a terminal disease. Prostatectomy and radiotherapy are effective for organ-confined diseases, but treatment for locally advanced and metastatic cancer remains challenging. Although advanced prostate cancers treated with androgen deprivation therapy achi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-05-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/5/2/569 |
| _version_ | 1797708346369769472 |
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| author | Archana Thakur Ulka Vaishampayan Lawrence G. Lum |
| author_facet | Archana Thakur Ulka Vaishampayan Lawrence G. Lum |
| author_sort | Archana Thakur |
| collection | DOAJ |
| description | Metastatic prostate cancer remains to this day a terminal disease. Prostatectomy and radiotherapy are effective for organ-confined diseases, but treatment for locally advanced and metastatic cancer remains challenging. Although advanced prostate cancers treated with androgen deprivation therapy achieves debulking of disease, responses are transient with subsequent development of castration-resistant and metastatic disease. Since prostate cancer is typically a slowly progressing disease, use of immune-based therapies offers an advantage to target advanced tumors and to induce antitumor immunity. This review will discuss the clinical merits of various vaccines and immunotherapies in castrate resistant prostate cancer and challenges to this evolving field of immune-based therapies. |
| first_indexed | 2024-03-12T06:20:07Z |
| format | Article |
| id | doaj.art-addba990399140fc8a36fce825c9aa47 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T06:20:07Z |
| publishDate | 2013-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-addba990399140fc8a36fce825c9aa472023-09-03T02:17:38ZengMDPI AGCancers2072-66942013-05-015256959010.3390/cancers5020569Immunotherapy and Immune Evasion in Prostate CancerArchana ThakurUlka VaishampayanLawrence G. LumMetastatic prostate cancer remains to this day a terminal disease. Prostatectomy and radiotherapy are effective for organ-confined diseases, but treatment for locally advanced and metastatic cancer remains challenging. Although advanced prostate cancers treated with androgen deprivation therapy achieves debulking of disease, responses are transient with subsequent development of castration-resistant and metastatic disease. Since prostate cancer is typically a slowly progressing disease, use of immune-based therapies offers an advantage to target advanced tumors and to induce antitumor immunity. This review will discuss the clinical merits of various vaccines and immunotherapies in castrate resistant prostate cancer and challenges to this evolving field of immune-based therapies.http://www.mdpi.com/2072-6694/5/2/569prostate cancerimmunotherapyvaccinecastrate resistant prostate cancerbispecific antibody |
| spellingShingle | Archana Thakur Ulka Vaishampayan Lawrence G. Lum Immunotherapy and Immune Evasion in Prostate Cancer Cancers prostate cancer immunotherapy vaccine castrate resistant prostate cancer bispecific antibody |
| title | Immunotherapy and Immune Evasion in Prostate Cancer |
| title_full | Immunotherapy and Immune Evasion in Prostate Cancer |
| title_fullStr | Immunotherapy and Immune Evasion in Prostate Cancer |
| title_full_unstemmed | Immunotherapy and Immune Evasion in Prostate Cancer |
| title_short | Immunotherapy and Immune Evasion in Prostate Cancer |
| title_sort | immunotherapy and immune evasion in prostate cancer |
| topic | prostate cancer immunotherapy vaccine castrate resistant prostate cancer bispecific antibody |
| url | http://www.mdpi.com/2072-6694/5/2/569 |
| work_keys_str_mv | AT archanathakur immunotherapyandimmuneevasioninprostatecancer AT ulkavaishampayan immunotherapyandimmuneevasioninprostatecancer AT lawrenceglum immunotherapyandimmuneevasioninprostatecancer |