Mitochondrial Structure and Polarity in Dendrites and the Axon Initial Segment Are Regulated by Homeostatic Plasticity and Dysregulated in Fragile X Syndrome

Mitochondrial Structure and Polarity in Dendrites and the Axon Initial Segment Are Regulated by Homeostatic Plasticity and Dysregulated in Fragile X Syndrome

Mitochondrial dysfunction has long been overlooked in neurodevelopmental disorders, but recent studies have provided new links to genetic forms of autism, including Rett syndrome and fragile X syndrome (FXS). Mitochondria show plasticity in morphology and function in response to neuronal activity, a...

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Bibliographic Details
Main Authors: Pernille Bülow, Peter A. Wenner, Victor Faundez, Gary J. Bassell
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Fmr1
FMRP
mitochondria
homeostatic plasticity
compartment-specific
dendrite
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.702020/full

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