Exploring the link between obesity and hypothyroidism in autoimmune thyroid diseases: a metabolic perspective
Background: The management of primary hypothyroidism demands a comprehensive approach that encompasses both the implications of autoimmune thyroid disease and the distinct effects posed by obesity and metabolic irregularities. Despite its clinical importance, the interplay between obesity and hypoth...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1379124/full |
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| author | Mengzhe Jing Mengzhe Jing Mengzhe Jing Shanshan Shao Shanshan Shao Shanshan Shao Shizhan Ma Shizhan Ma Shizhan Ma Ling Gao Ling Gao Ling Gao Qian Wang Meng Zhou Meng Zhou Meng Zhou |
| author_facet | Mengzhe Jing Mengzhe Jing Mengzhe Jing Shanshan Shao Shanshan Shao Shanshan Shao Shizhan Ma Shizhan Ma Shizhan Ma Ling Gao Ling Gao Ling Gao Qian Wang Meng Zhou Meng Zhou Meng Zhou |
| author_sort | Mengzhe Jing |
| collection | DOAJ |
| description | Background: The management of primary hypothyroidism demands a comprehensive approach that encompasses both the implications of autoimmune thyroid disease and the distinct effects posed by obesity and metabolic irregularities. Despite its clinical importance, the interplay between obesity and hypothyroidism, especially in the context of metabolic perspectives, is insufficiently explored in existing research. This study endeavors to classify hypothyroidism by considering the presence of autoimmune thyroid disease and to examine its correlation with various metabolic obesity phenotypes.Method: This research was conducted by analyzing data from 1,170 individuals enrolled in the Thyroid Disease Database of Shandong Provincial Hospital. We assessed four distinct metabolic health statuses among the participants: Metabolically Healthy No Obese Metabolically Healthy Obese Metabolically Unhealthy No Obese and Metabolically Unhealthy Obese Utilizing logistic regression, we investigated the association between various metabolic obesity phenotypes and hypothyroidism.Results: The study revealed a significant correlation between the Metabolically Unhealthy Obese (MUO) phenotype and hypothyroidism, particularly among women who do not have thyroid autoimmunity. Notably, the Metabolically Unhealthy No Obese (MUNO) phenotype showed a significant association with hypothyroidism in individuals with thyroid autoimmunity, with a pronounced prevalence in women. Furthermore, elevated levels of triglycerides and blood glucose were found to be significantly associated with hypothyroidism in men with thyroid autoimmunity and in women without thyroid autoimmunity.Conclusion: Effective treatment of hypothyroidism requires a thorough understanding of the process of thyroid autoimmune development. In patients without concurrent thyroid autoimmunity, there is a notable correlation between obesity and metabolic issues with reduced thyroid function. Conversely, for patients with thyroid autoimmunity, a focused approach on managing metabolic abnormalities, especially triglyceride levels, is crucial. |
| first_indexed | 2024-04-24T07:04:34Z |
| format | Article |
| id | doaj.art-ade2a7068dfb4b50b72afe8b8e02c005 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-24T07:04:34Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-ade2a7068dfb4b50b72afe8b8e02c0052024-04-22T05:04:14ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2024-04-011110.3389/fmolb.2024.13791241379124Exploring the link between obesity and hypothyroidism in autoimmune thyroid diseases: a metabolic perspectiveMengzhe Jing0Mengzhe Jing1Mengzhe Jing2Shanshan Shao3Shanshan Shao4Shanshan Shao5Shizhan Ma6Shizhan Ma7Shizhan Ma8Ling Gao9Ling Gao10Ling Gao11Qian Wang12Meng Zhou13Meng Zhou14Meng Zhou15Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, ChinaShandong Institute of Endocrine and Metabolic Disease, Jinan, Shandong, ChinaKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, ChinaShandong Institute of Endocrine and Metabolic Disease, Jinan, Shandong, ChinaKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, ChinaShandong Institute of Endocrine and Metabolic Disease, Jinan, Shandong, ChinaKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, ChinaShandong Institute of Endocrine and Metabolic Disease, Jinan, Shandong, ChinaDepartment of Ultrasound, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, ChinaShandong Institute of Endocrine and Metabolic Disease, Jinan, Shandong, ChinaBackground: The management of primary hypothyroidism demands a comprehensive approach that encompasses both the implications of autoimmune thyroid disease and the distinct effects posed by obesity and metabolic irregularities. Despite its clinical importance, the interplay between obesity and hypothyroidism, especially in the context of metabolic perspectives, is insufficiently explored in existing research. This study endeavors to classify hypothyroidism by considering the presence of autoimmune thyroid disease and to examine its correlation with various metabolic obesity phenotypes.Method: This research was conducted by analyzing data from 1,170 individuals enrolled in the Thyroid Disease Database of Shandong Provincial Hospital. We assessed four distinct metabolic health statuses among the participants: Metabolically Healthy No Obese Metabolically Healthy Obese Metabolically Unhealthy No Obese and Metabolically Unhealthy Obese Utilizing logistic regression, we investigated the association between various metabolic obesity phenotypes and hypothyroidism.Results: The study revealed a significant correlation between the Metabolically Unhealthy Obese (MUO) phenotype and hypothyroidism, particularly among women who do not have thyroid autoimmunity. Notably, the Metabolically Unhealthy No Obese (MUNO) phenotype showed a significant association with hypothyroidism in individuals with thyroid autoimmunity, with a pronounced prevalence in women. Furthermore, elevated levels of triglycerides and blood glucose were found to be significantly associated with hypothyroidism in men with thyroid autoimmunity and in women without thyroid autoimmunity.Conclusion: Effective treatment of hypothyroidism requires a thorough understanding of the process of thyroid autoimmune development. In patients without concurrent thyroid autoimmunity, there is a notable correlation between obesity and metabolic issues with reduced thyroid function. Conversely, for patients with thyroid autoimmunity, a focused approach on managing metabolic abnormalities, especially triglyceride levels, is crucial.https://www.frontiersin.org/articles/10.3389/fmolb.2024.1379124/fullmetabolic obesity phenotypeshypothyroidismtriglyceridemetabolismautoimmune thyroid disease |
| spellingShingle | Mengzhe Jing Mengzhe Jing Mengzhe Jing Shanshan Shao Shanshan Shao Shanshan Shao Shizhan Ma Shizhan Ma Shizhan Ma Ling Gao Ling Gao Ling Gao Qian Wang Meng Zhou Meng Zhou Meng Zhou Exploring the link between obesity and hypothyroidism in autoimmune thyroid diseases: a metabolic perspective Frontiers in Molecular Biosciences metabolic obesity phenotypes hypothyroidism triglyceride metabolism autoimmune thyroid disease |
| title | Exploring the link between obesity and hypothyroidism in autoimmune thyroid diseases: a metabolic perspective |
| title_full | Exploring the link between obesity and hypothyroidism in autoimmune thyroid diseases: a metabolic perspective |
| title_fullStr | Exploring the link between obesity and hypothyroidism in autoimmune thyroid diseases: a metabolic perspective |
| title_full_unstemmed | Exploring the link between obesity and hypothyroidism in autoimmune thyroid diseases: a metabolic perspective |
| title_short | Exploring the link between obesity and hypothyroidism in autoimmune thyroid diseases: a metabolic perspective |
| title_sort | exploring the link between obesity and hypothyroidism in autoimmune thyroid diseases a metabolic perspective |
| topic | metabolic obesity phenotypes hypothyroidism triglyceride metabolism autoimmune thyroid disease |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1379124/full |
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