The Role of Stereotactic Frame-Based Biopsy for Brainstem Tumors in the Era of Molecular-Based Diagnosis and Treatment Decisions
Stereotactic frame-based brain tumor biopsy (SFB) is a potent diagnostic tool considering its minimal invasiveness, though its diagnostic power and safety for brainstem lesions remain to be discussed. Here, we aimed to examine the usefulness of SFB for brainstem tumors. Twenty-two patients with brai...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/29/7/360 |
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| author | Yudai Hirano Yuki Shinya Toshiya Aono Hirotaka Hasegawa Mariko Kawashima Masahiro Shin Hirokazu Takami Shunsaku Takayanagi Motoyuki Umekawa Masako Ikemura Tetsuo Ushiku Kazuki Taoka Shota Tanaka Nobuhito Saito |
| author_facet | Yudai Hirano Yuki Shinya Toshiya Aono Hirotaka Hasegawa Mariko Kawashima Masahiro Shin Hirokazu Takami Shunsaku Takayanagi Motoyuki Umekawa Masako Ikemura Tetsuo Ushiku Kazuki Taoka Shota Tanaka Nobuhito Saito |
| author_sort | Yudai Hirano |
| collection | DOAJ |
| description | Stereotactic frame-based brain tumor biopsy (SFB) is a potent diagnostic tool considering its minimal invasiveness, though its diagnostic power and safety for brainstem lesions remain to be discussed. Here, we aimed to examine the usefulness of SFB for brainstem tumors. Twenty-two patients with brainstem tumors underwent 23 SFBs at our institution during 2002–2021. We retrospectively analyzed patient characteristics, tumor pathology, surgical procedures, and outcomes, including surgery-related complications and the diagnostic value. Seven (32%) tumors were located from the midbrain to the pons, eleven (50%) in the pons only, and four (18%) from the pons to the medulla oblongata. The target lesions were in the middle cerebellar peduncles in sixteen procedures (70%), the cerebellum in four (17%), the inferior cerebellar peduncles in two (9%), and the superior cerebellar peduncles in one (4%). A definitive diagnosis was made in 21 patients (95%) at the first SFB. The diagnoses were glioma in seventeen (77%) cases, primary central nervous system lymphoma in four (18%), and a metastatic brain tumor in one (5%). The postoperative complications (cranial nerve palsy in three [13%] cases, ataxia in one [4%]) were all transient. SFB for brainstem tumors yields a high diagnostic rate with a low risk of morbidity. |
| first_indexed | 2024-03-09T12:02:57Z |
| format | Article |
| id | doaj.art-ade42be5c2904ecd818410cd38103dbf |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T12:02:57Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-ade42be5c2904ecd818410cd38103dbf2023-11-30T23:01:53ZengMDPI AGCurrent Oncology1198-00521718-77292022-06-012974558456510.3390/curroncol29070360The Role of Stereotactic Frame-Based Biopsy for Brainstem Tumors in the Era of Molecular-Based Diagnosis and Treatment DecisionsYudai Hirano0Yuki Shinya1Toshiya Aono2Hirotaka Hasegawa3Mariko Kawashima4Masahiro Shin5Hirokazu Takami6Shunsaku Takayanagi7Motoyuki Umekawa8Masako Ikemura9Tetsuo Ushiku10Kazuki Taoka11Shota Tanaka12Nobuhito Saito13Department of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Neurosurgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-0003, JapanDepartment of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Pathology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Pathology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Hematology and Oncology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Neurosurgery, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JapanStereotactic frame-based brain tumor biopsy (SFB) is a potent diagnostic tool considering its minimal invasiveness, though its diagnostic power and safety for brainstem lesions remain to be discussed. Here, we aimed to examine the usefulness of SFB for brainstem tumors. Twenty-two patients with brainstem tumors underwent 23 SFBs at our institution during 2002–2021. We retrospectively analyzed patient characteristics, tumor pathology, surgical procedures, and outcomes, including surgery-related complications and the diagnostic value. Seven (32%) tumors were located from the midbrain to the pons, eleven (50%) in the pons only, and four (18%) from the pons to the medulla oblongata. The target lesions were in the middle cerebellar peduncles in sixteen procedures (70%), the cerebellum in four (17%), the inferior cerebellar peduncles in two (9%), and the superior cerebellar peduncles in one (4%). A definitive diagnosis was made in 21 patients (95%) at the first SFB. The diagnoses were glioma in seventeen (77%) cases, primary central nervous system lymphoma in four (18%), and a metastatic brain tumor in one (5%). The postoperative complications (cranial nerve palsy in three [13%] cases, ataxia in one [4%]) were all transient. SFB for brainstem tumors yields a high diagnostic rate with a low risk of morbidity.https://www.mdpi.com/1718-7729/29/7/360stereotactic biopsybrainstem tumorframe-based |
| spellingShingle | Yudai Hirano Yuki Shinya Toshiya Aono Hirotaka Hasegawa Mariko Kawashima Masahiro Shin Hirokazu Takami Shunsaku Takayanagi Motoyuki Umekawa Masako Ikemura Tetsuo Ushiku Kazuki Taoka Shota Tanaka Nobuhito Saito The Role of Stereotactic Frame-Based Biopsy for Brainstem Tumors in the Era of Molecular-Based Diagnosis and Treatment Decisions Current Oncology stereotactic biopsy brainstem tumor frame-based |
| title | The Role of Stereotactic Frame-Based Biopsy for Brainstem Tumors in the Era of Molecular-Based Diagnosis and Treatment Decisions |
| title_full | The Role of Stereotactic Frame-Based Biopsy for Brainstem Tumors in the Era of Molecular-Based Diagnosis and Treatment Decisions |
| title_fullStr | The Role of Stereotactic Frame-Based Biopsy for Brainstem Tumors in the Era of Molecular-Based Diagnosis and Treatment Decisions |
| title_full_unstemmed | The Role of Stereotactic Frame-Based Biopsy for Brainstem Tumors in the Era of Molecular-Based Diagnosis and Treatment Decisions |
| title_short | The Role of Stereotactic Frame-Based Biopsy for Brainstem Tumors in the Era of Molecular-Based Diagnosis and Treatment Decisions |
| title_sort | role of stereotactic frame based biopsy for brainstem tumors in the era of molecular based diagnosis and treatment decisions |
| topic | stereotactic biopsy brainstem tumor frame-based |
| url | https://www.mdpi.com/1718-7729/29/7/360 |
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