Silver(I) complexes with phenolic Schiff bases: Synthesis, anti-bacterial evaluation and interaction with biomolecules
Novel Ag(I) complexes (2a–2c) with phenolic Schiff bases were synthesized using 4,6-di-tert-butyl-3-(((5-mercapto-1,3,4-thiadiazol-2-yl)imino)methyl)benzene-1,2-diol (1a), 4,6-di-tert-butyl-3-(((4-mercaptophenyl)imino)methyl)benzene-1,2-diol (1b), and 4,6-di-tert-butyl-3-(((3-mercaptophenyl)imi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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International Association of Physical Chemists (IAPC)
2022-03-01
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| Series: | ADMET and DMPK |
| Online Access: | https://pub.iapchem.org/ojs/index.php/admet/article/view/1167 |
| _version_ | 1818445516063637504 |
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| author | Natalia Loginova Maxim Gvozdev Nikolai Osipovich Alina Khodosovskaya Tatiana Koval’chuk-Rabchinskaya Galina Ksendzova Dzmitry Kotsikau Anatoly Evtushenkov |
| author_facet | Natalia Loginova Maxim Gvozdev Nikolai Osipovich Alina Khodosovskaya Tatiana Koval’chuk-Rabchinskaya Galina Ksendzova Dzmitry Kotsikau Anatoly Evtushenkov |
| author_sort | Natalia Loginova |
| collection | DOAJ |
| description |
Novel Ag(I) complexes (2a–2c) with phenolic Schiff bases were synthesized using 4,6-di-tert-butyl-3-(((5-mercapto-1,3,4-thiadiazol-2-yl)imino)methyl)benzene-1,2-diol (1a), 4,6-di-tert-butyl-3-(((4-mercaptophenyl)imino)methyl)benzene-1,2-diol (1b), and 4,6-di-tert-butyl-3-(((3-mercaptophenyl)imino)methyl)benzene-1,2-diol (1c). They were examined by elemental analysis, FT-IR, UV-Vis, 1H-NMR spectroscopy, XRD, cyclic voltammetry, conductivity measurements, and biological methods. The complexes are characterized by distorted geometry of the coordination cores AgN2S2 (2c), AgNS (2b) and AgS2 (2a). These stable complexes were not typified by the intramolecular redox reaction in organic solvents resulting in the formation of silver nanoparticles (AgNPs). Antibacterial activity of 1a–1c and 2a–2c was evaluated in comparison with AgNPs and commonly used antibiotics. All the complexes were more active than the ligands against the bacteria tested (14), but they were less active than AgNPs and commonly used antibiotics. Both 1a–1c and their complexes 2a–2c exhibited the capability for the bovine heart Fe(III)-Cyt c reduction. The ligands 1b and 1c were characterized by the highest reduction rate among the compounds under study, and they showed a higher reducing ability (determined by cyclic voltammetry) as compared with that of their Ag(I) complexes 2b and 2c.
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| first_indexed | 2024-12-14T19:33:04Z |
| format | Article |
| id | doaj.art-ade5021739244bc9af732bba7ff6ec63 |
| institution | Directory Open Access Journal |
| issn | 1848-7718 |
| language | English |
| last_indexed | 2024-12-14T19:33:04Z |
| publishDate | 2022-03-01 |
| publisher | International Association of Physical Chemists (IAPC) |
| record_format | Article |
| series | ADMET and DMPK |
| spelling | doaj.art-ade5021739244bc9af732bba7ff6ec632022-12-21T22:50:00ZengInternational Association of Physical Chemists (IAPC)ADMET and DMPK1848-77182022-03-0110.5599/admet.1167Silver(I) complexes with phenolic Schiff bases: Synthesis, anti-bacterial evaluation and interaction with biomoleculesNatalia Loginova0Maxim Gvozdev1Nikolai Osipovich2Alina Khodosovskaya3Tatiana Koval’chuk-Rabchinskaya4Galina Ksendzova5Dzmitry Kotsikau6Anatoly Evtushenkov7Faculty of Chemistry, Belarusian State University, Minsk, BelarusFaculty of Chemistry, Belarusian State University, Minsk, BelarusResearch Institute for Physico-Chemical Problems of the Belarusian State University, Minsk, BelarusFaculty of Biology, Belarusian State University, Minsk, BelarusFaculty of Chemistry, Belarusian State University, Minsk, BelarusResearch Institute for Physico-Chemical Problems of the Belarusian State University, Minsk, BelarusFaculty of Chemistry, Belarusian State University, Minsk, BelarusFaculty of Biology, Belarusian State University, Minsk, Belarus Novel Ag(I) complexes (2a–2c) with phenolic Schiff bases were synthesized using 4,6-di-tert-butyl-3-(((5-mercapto-1,3,4-thiadiazol-2-yl)imino)methyl)benzene-1,2-diol (1a), 4,6-di-tert-butyl-3-(((4-mercaptophenyl)imino)methyl)benzene-1,2-diol (1b), and 4,6-di-tert-butyl-3-(((3-mercaptophenyl)imino)methyl)benzene-1,2-diol (1c). They were examined by elemental analysis, FT-IR, UV-Vis, 1H-NMR spectroscopy, XRD, cyclic voltammetry, conductivity measurements, and biological methods. The complexes are characterized by distorted geometry of the coordination cores AgN2S2 (2c), AgNS (2b) and AgS2 (2a). These stable complexes were not typified by the intramolecular redox reaction in organic solvents resulting in the formation of silver nanoparticles (AgNPs). Antibacterial activity of 1a–1c and 2a–2c was evaluated in comparison with AgNPs and commonly used antibiotics. All the complexes were more active than the ligands against the bacteria tested (14), but they were less active than AgNPs and commonly used antibiotics. Both 1a–1c and their complexes 2a–2c exhibited the capability for the bovine heart Fe(III)-Cyt c reduction. The ligands 1b and 1c were characterized by the highest reduction rate among the compounds under study, and they showed a higher reducing ability (determined by cyclic voltammetry) as compared with that of their Ag(I) complexes 2b and 2c. https://pub.iapchem.org/ojs/index.php/admet/article/view/1167 |
| spellingShingle | Natalia Loginova Maxim Gvozdev Nikolai Osipovich Alina Khodosovskaya Tatiana Koval’chuk-Rabchinskaya Galina Ksendzova Dzmitry Kotsikau Anatoly Evtushenkov Silver(I) complexes with phenolic Schiff bases: Synthesis, anti-bacterial evaluation and interaction with biomolecules ADMET and DMPK |
| title | Silver(I) complexes with phenolic Schiff bases: Synthesis, anti-bacterial evaluation and interaction with biomolecules |
| title_full | Silver(I) complexes with phenolic Schiff bases: Synthesis, anti-bacterial evaluation and interaction with biomolecules |
| title_fullStr | Silver(I) complexes with phenolic Schiff bases: Synthesis, anti-bacterial evaluation and interaction with biomolecules |
| title_full_unstemmed | Silver(I) complexes with phenolic Schiff bases: Synthesis, anti-bacterial evaluation and interaction with biomolecules |
| title_short | Silver(I) complexes with phenolic Schiff bases: Synthesis, anti-bacterial evaluation and interaction with biomolecules |
| title_sort | silver i complexes with phenolic schiff bases synthesis anti bacterial evaluation and interaction with biomolecules |
| url | https://pub.iapchem.org/ojs/index.php/admet/article/view/1167 |
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