Prevalence and Clinical Profiling of Dysglycemia and HIV Infection in Persons With Pulmonary Tuberculosis in Brazil
BackgroundThere are scarce data on the prevalence and disease presentation of HIV in patients with tuberculosis (TB) and dysglycemia (diabetes [DM] and prediabetes [PDM]), especially in TB-endemic countries.MethodsWe assessed the baseline epidemiological and clinical characteristics of patients with...
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.804173/full |
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| author | María B. Arriaga María B. Arriaga María B. Arriaga Mariana Araújo-Pereira Mariana Araújo-Pereira Mariana Araújo-Pereira Beatriz Barreto-Duarte Beatriz Barreto-Duarte Beatriz Barreto-Duarte Beatriz Barreto-Duarte Caio Sales Caio Sales Caio Sales João Pedro Miguez-Pinto João Pedro Miguez-Pinto João Pedro Miguez-Pinto Evelyn B. Nogueira Evelyn B. Nogueira Evelyn B. Nogueira Betânia M. F. Nogueira Betânia M. F. Nogueira Betânia M. F. Nogueira Betânia M. F. Nogueira Michael S. Rocha Michael S. Rocha Michael S. Rocha Michael S. Rocha Alexandra B. Souza Alexandra B. Souza Aline Benjamin Jamile G. de Oliveira Adriana S. R. Moreira Artur T. L. Queiroz Artur T. L. Queiroz Moreno M. S. Rodrigues Renata Spener-Gomes Renata Spener-Gomes Marina C. Figueiredo Betina Durovni Solange Cavalcante José R. Lapa-e-Silva José R. Lapa-e-Silva Afrânio L. Kristki Afrânio L. Kristki Marcelo Cordeiro-Santos Marcelo Cordeiro-Santos Marcelo Cordeiro-Santos Timothy R. Sterling Valeria C. Rolla Bruno B. Andrade Bruno B. Andrade Bruno B. Andrade Bruno B. Andrade Bruno B. Andrade Bruno B. Andrade the RePORT-Brazil consortium Alice M. S. Andrade Juan M. Cubillos-Angulo Hayna Malta-Santos Jéssica Rebouças-Silva Saulo R. N. Santos André Ramos Alysson G. Costa Jaquelane Silva Adriano Gomes-Silva Flávia M. Sant'Anna Francine P. Ignácio Vanessa Nascimento Maria Cristina Lourenço Elisangela C. Silva Mayla Mello |
| author_facet | María B. Arriaga María B. Arriaga María B. Arriaga Mariana Araújo-Pereira Mariana Araújo-Pereira Mariana Araújo-Pereira Beatriz Barreto-Duarte Beatriz Barreto-Duarte Beatriz Barreto-Duarte Beatriz Barreto-Duarte Caio Sales Caio Sales Caio Sales João Pedro Miguez-Pinto João Pedro Miguez-Pinto João Pedro Miguez-Pinto Evelyn B. Nogueira Evelyn B. Nogueira Evelyn B. Nogueira Betânia M. F. Nogueira Betânia M. F. Nogueira Betânia M. F. Nogueira Betânia M. F. Nogueira Michael S. Rocha Michael S. Rocha Michael S. Rocha Michael S. Rocha Alexandra B. Souza Alexandra B. Souza Aline Benjamin Jamile G. de Oliveira Adriana S. R. Moreira Artur T. L. Queiroz Artur T. L. Queiroz Moreno M. S. Rodrigues Renata Spener-Gomes Renata Spener-Gomes Marina C. Figueiredo Betina Durovni Solange Cavalcante José R. Lapa-e-Silva José R. Lapa-e-Silva Afrânio L. Kristki Afrânio L. Kristki Marcelo Cordeiro-Santos Marcelo Cordeiro-Santos Marcelo Cordeiro-Santos Timothy R. Sterling Valeria C. Rolla Bruno B. Andrade Bruno B. Andrade Bruno B. Andrade Bruno B. Andrade Bruno B. Andrade Bruno B. Andrade the RePORT-Brazil consortium Alice M. S. Andrade Juan M. Cubillos-Angulo Hayna Malta-Santos Jéssica Rebouças-Silva Saulo R. N. Santos André Ramos Alysson G. Costa Jaquelane Silva Adriano Gomes-Silva Flávia M. Sant'Anna Francine P. Ignácio Vanessa Nascimento Maria Cristina Lourenço Elisangela C. Silva Mayla Mello |
| author_sort | María B. Arriaga |
| collection | DOAJ |
| description | BackgroundThere are scarce data on the prevalence and disease presentation of HIV in patients with tuberculosis (TB) and dysglycemia (diabetes [DM] and prediabetes [PDM]), especially in TB-endemic countries.MethodsWe assessed the baseline epidemiological and clinical characteristics of patients with culture-confirmed pulmonary TB, enrolled in a multicenter prospective cohort in Brazil (RePORT-Brazil) during 2015–2019. Dysglycemia was defined by elevated glycated hemoglobin and stratified as PDM or DM. Additionally, we used data from TB cases obtained through the Brazilian National Notifiable Diseases Information System (SINAN), during 2015–2019. In SINAN, diagnosis of diabetes was based on self-report. Logistic regression models were performed to test independent associations between HIV, dysglycemia status, and other baseline characteristics in both cohorts.ResultsIn the RePORT-Brazil cohort, the prevalence of DM and of PDM was 23.7 and 37.8%, respectively. Furthermore, the prevalence of HIV was 21.4% in the group of persons with TB-dysglycemia and 20.5% in that of patients with TBDM. In the SINAN cohort, the prevalence of DM was 9.2%, and among the TBDM group the prevalence of HIV was 4.1%. Logistic regressions demonstrated that aging was independently associated with PDM or DM in both the RePORT-Brazil and SINAN cohorts. In RePORT-Brazil, illicit drug use was associated with PDM, whereas a higher body mass index (BMI) was associated with DM occurrence. Of note, HIV was not associated with an increased risk of PDM or DM in patients with pulmonary TB in both cohorts. Moreover, in both cohorts, the TBDM-HIV group presented with a lower proportion of positive sputum smear and a higher frequency of tobacco and alcohol users.ConclusionThere is a high prevalence of dysglycemia in patients with pulmonary TB in Brazil, regardless of the HIV status. This reinforces the idea that DM should be systematically screened in persons with TB. Presence of HIV does not substantially impact clinical presentation in persons with TBDM, although it is associated with more frequent use of recreational drugs and smear negative sputum samples during TB screening. |
| first_indexed | 2024-12-20T16:07:12Z |
| format | Article |
| id | doaj.art-ade511e162de4cc39479f65b67984f38 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-20T16:07:12Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-ade511e162de4cc39479f65b67984f382022-12-21T19:34:06ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-01-01810.3389/fmed.2021.804173804173Prevalence and Clinical Profiling of Dysglycemia and HIV Infection in Persons With Pulmonary Tuberculosis in BrazilMaría B. Arriaga0María B. Arriaga1María B. Arriaga2Mariana Araújo-Pereira3Mariana Araújo-Pereira4Mariana Araújo-Pereira5Beatriz Barreto-Duarte6Beatriz Barreto-Duarte7Beatriz Barreto-Duarte8Beatriz Barreto-Duarte9Caio Sales10Caio Sales11Caio Sales12João Pedro Miguez-Pinto13João Pedro Miguez-Pinto14João Pedro Miguez-Pinto15Evelyn B. Nogueira16Evelyn B. Nogueira17Evelyn B. Nogueira18Betânia M. F. Nogueira19Betânia M. F. Nogueira20Betânia M. F. Nogueira21Betânia M. F. Nogueira22Michael S. Rocha23Michael S. Rocha24Michael S. Rocha25Michael S. Rocha26Alexandra B. Souza27Alexandra B. Souza28Aline Benjamin29Jamile G. de Oliveira30Adriana S. R. Moreira31Artur T. L. Queiroz32Artur T. L. Queiroz33Moreno M. S. Rodrigues34Renata Spener-Gomes35Renata Spener-Gomes36Marina C. Figueiredo37Betina Durovni38Solange Cavalcante39José R. Lapa-e-Silva40José R. Lapa-e-Silva41Afrânio L. Kristki42Afrânio L. Kristki43Marcelo Cordeiro-Santos44Marcelo Cordeiro-Santos45Marcelo Cordeiro-Santos46Timothy R. Sterling47Valeria C. Rolla48Bruno B. Andrade49Bruno B. Andrade50Bruno B. Andrade51Bruno B. Andrade52Bruno B. Andrade53Bruno B. Andrade54the RePORT-Brazil consortiumAlice M. S. AndradeJuan M. Cubillos-AnguloHayna Malta-SantosJéssica Rebouças-SilvaSaulo R. N. SantosAndré RamosAlysson G. CostaJaquelane SilvaAdriano Gomes-SilvaFlávia M. Sant'AnnaFrancine P. IgnácioVanessa NascimentoMaria Cristina LourençoElisangela C. SilvaMayla MelloLaboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BrazilMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, BrazilFaculdade de Medicina, Universidade Federal da Bahia, Salvador, BrazilLaboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BrazilMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, BrazilFaculdade de Medicina, Universidade Federal da Bahia, Salvador, BrazilLaboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BrazilMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, BrazilEscola de Medicina, Universidade Salvador (UNIFACS), Salvador, BrazilPrograma de Pós-Graduação em Clínica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilLaboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BrazilMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, BrazilEscola de Medicina, Universidade Salvador (UNIFACS), Salvador, BrazilLaboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BrazilMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, BrazilEscola de Medicina, Universidade Salvador (UNIFACS), Salvador, BrazilLaboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BrazilMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, BrazilEscola de Medicina, Universidade Salvador (UNIFACS), Salvador, BrazilLaboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BrazilMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, BrazilFaculdade de Medicina, Universidade Federal da Bahia, Salvador, BrazilInstituto Brasileiro para Investigação da Tuberculose, Fundação José Silveira, Salvador, BrazilLaboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BrazilMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, BrazilInstituto Brasileiro para Investigação da Tuberculose, Fundação José Silveira, Salvador, BrazilEscola Bahiana de Medicina e Saúde Pública, Salvador, BrazilFundação Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil0Laboratório de Pesquisa Clínica em Micobacteriose, Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro, Brazil1Secretaria Municipal de Saúde do Rio de Janeiro, Rio de Janeiro, Brazil2Programa Acadêmico de Tuberculose da Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil3Center of Data and Knowledge Integration for Health, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil4Laboratório de Análise e Visualização de Dados, Fundação Oswaldo Cruz, Porto Velho, BrazilFundação Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil5Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States1Secretaria Municipal de Saúde do Rio de Janeiro, Rio de Janeiro, Brazil1Secretaria Municipal de Saúde do Rio de Janeiro, Rio de Janeiro, BrazilPrograma de Pós-Graduação em Clínica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil2Programa Acadêmico de Tuberculose da Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilPrograma de Pós-Graduação em Clínica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil2Programa Acadêmico de Tuberculose da Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilFundação Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Brazil6Faculdade de Medicina, Universidade Nilton Lins, Manaus, Brazil5Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States0Laboratório de Pesquisa Clínica em Micobacteriose, Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro, BrazilLaboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BrazilMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, BrazilFaculdade de Medicina, Universidade Federal da Bahia, Salvador, BrazilEscola de Medicina, Universidade Salvador (UNIFACS), Salvador, BrazilEscola Bahiana de Medicina e Saúde Pública, Salvador, Brazil5Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United StatesBackgroundThere are scarce data on the prevalence and disease presentation of HIV in patients with tuberculosis (TB) and dysglycemia (diabetes [DM] and prediabetes [PDM]), especially in TB-endemic countries.MethodsWe assessed the baseline epidemiological and clinical characteristics of patients with culture-confirmed pulmonary TB, enrolled in a multicenter prospective cohort in Brazil (RePORT-Brazil) during 2015–2019. Dysglycemia was defined by elevated glycated hemoglobin and stratified as PDM or DM. Additionally, we used data from TB cases obtained through the Brazilian National Notifiable Diseases Information System (SINAN), during 2015–2019. In SINAN, diagnosis of diabetes was based on self-report. Logistic regression models were performed to test independent associations between HIV, dysglycemia status, and other baseline characteristics in both cohorts.ResultsIn the RePORT-Brazil cohort, the prevalence of DM and of PDM was 23.7 and 37.8%, respectively. Furthermore, the prevalence of HIV was 21.4% in the group of persons with TB-dysglycemia and 20.5% in that of patients with TBDM. In the SINAN cohort, the prevalence of DM was 9.2%, and among the TBDM group the prevalence of HIV was 4.1%. Logistic regressions demonstrated that aging was independently associated with PDM or DM in both the RePORT-Brazil and SINAN cohorts. In RePORT-Brazil, illicit drug use was associated with PDM, whereas a higher body mass index (BMI) was associated with DM occurrence. Of note, HIV was not associated with an increased risk of PDM or DM in patients with pulmonary TB in both cohorts. Moreover, in both cohorts, the TBDM-HIV group presented with a lower proportion of positive sputum smear and a higher frequency of tobacco and alcohol users.ConclusionThere is a high prevalence of dysglycemia in patients with pulmonary TB in Brazil, regardless of the HIV status. This reinforces the idea that DM should be systematically screened in persons with TB. Presence of HIV does not substantially impact clinical presentation in persons with TBDM, although it is associated with more frequent use of recreational drugs and smear negative sputum samples during TB screening.https://www.frontiersin.org/articles/10.3389/fmed.2021.804173/fulldysglycemiaHIV infectionpulmonary tuberculosisMycobacterium tuberculosisdiabetes |
| spellingShingle | María B. Arriaga María B. Arriaga María B. Arriaga Mariana Araújo-Pereira Mariana Araújo-Pereira Mariana Araújo-Pereira Beatriz Barreto-Duarte Beatriz Barreto-Duarte Beatriz Barreto-Duarte Beatriz Barreto-Duarte Caio Sales Caio Sales Caio Sales João Pedro Miguez-Pinto João Pedro Miguez-Pinto João Pedro Miguez-Pinto Evelyn B. Nogueira Evelyn B. Nogueira Evelyn B. Nogueira Betânia M. F. Nogueira Betânia M. F. Nogueira Betânia M. F. Nogueira Betânia M. F. Nogueira Michael S. Rocha Michael S. Rocha Michael S. Rocha Michael S. Rocha Alexandra B. Souza Alexandra B. Souza Aline Benjamin Jamile G. de Oliveira Adriana S. R. Moreira Artur T. L. Queiroz Artur T. L. Queiroz Moreno M. S. Rodrigues Renata Spener-Gomes Renata Spener-Gomes Marina C. Figueiredo Betina Durovni Solange Cavalcante José R. Lapa-e-Silva José R. Lapa-e-Silva Afrânio L. Kristki Afrânio L. Kristki Marcelo Cordeiro-Santos Marcelo Cordeiro-Santos Marcelo Cordeiro-Santos Timothy R. Sterling Valeria C. Rolla Bruno B. Andrade Bruno B. Andrade Bruno B. Andrade Bruno B. Andrade Bruno B. Andrade Bruno B. Andrade the RePORT-Brazil consortium Alice M. S. Andrade Juan M. Cubillos-Angulo Hayna Malta-Santos Jéssica Rebouças-Silva Saulo R. N. Santos André Ramos Alysson G. Costa Jaquelane Silva Adriano Gomes-Silva Flávia M. Sant'Anna Francine P. Ignácio Vanessa Nascimento Maria Cristina Lourenço Elisangela C. Silva Mayla Mello Prevalence and Clinical Profiling of Dysglycemia and HIV Infection in Persons With Pulmonary Tuberculosis in Brazil Frontiers in Medicine dysglycemia HIV infection pulmonary tuberculosis Mycobacterium tuberculosis diabetes |
| title | Prevalence and Clinical Profiling of Dysglycemia and HIV Infection in Persons With Pulmonary Tuberculosis in Brazil |
| title_full | Prevalence and Clinical Profiling of Dysglycemia and HIV Infection in Persons With Pulmonary Tuberculosis in Brazil |
| title_fullStr | Prevalence and Clinical Profiling of Dysglycemia and HIV Infection in Persons With Pulmonary Tuberculosis in Brazil |
| title_full_unstemmed | Prevalence and Clinical Profiling of Dysglycemia and HIV Infection in Persons With Pulmonary Tuberculosis in Brazil |
| title_short | Prevalence and Clinical Profiling of Dysglycemia and HIV Infection in Persons With Pulmonary Tuberculosis in Brazil |
| title_sort | prevalence and clinical profiling of dysglycemia and hiv infection in persons with pulmonary tuberculosis in brazil |
| topic | dysglycemia HIV infection pulmonary tuberculosis Mycobacterium tuberculosis diabetes |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.804173/full |
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