False positive results using calcitonin as a screening method for medullary thyroid carcinoma
The role of serum calcitonin as part of the evaluation of thyroid nodules has been widely discussed in literature. However there still is no consensus of measurement of calcitonin in the initial evaluation of a patient with thyroid nodule. Problems concerning cost-benefit, lab methods, false positiv...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2013;volume=17;issue=3;spage=524;epage=528;aulast=Batista |
| _version_ | 1811334944755023872 |
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| author | Rafael Loch Batista Andrea Cecilia Toscanini Lenine Garcia Brandão Malebranche Berardo C Cunha-Neto |
| author_facet | Rafael Loch Batista Andrea Cecilia Toscanini Lenine Garcia Brandão Malebranche Berardo C Cunha-Neto |
| author_sort | Rafael Loch Batista |
| collection | DOAJ |
| description | The role of serum calcitonin as part of the evaluation of thyroid nodules has been widely discussed in literature. However there still is no consensus of measurement of calcitonin in the initial evaluation of a patient with thyroid nodule. Problems concerning cost-benefit, lab methods, false positive and low prevalence of medullary thyroid carcinoma (MTC) are factors that limit this approach. We have illustrated two cases where serum calcitonin was used in the evaluation of thyroid nodule and rates proved to be high. A stimulation test was performed, using calcium as secretagogue, and calcitonin hyper-stimulation was confirmed, but anatomopathologic examination did not evidence medullar neoplasia. Anatomopathologic diagnosis detected Hashimoto thyroiditis in one case and adenomatous goiter plus an occult papillary thyroid carcinoma in the other one. Recommendation for routine use of serum calcitonin in the initial diagnostic evaluation of a thyroid nodule, followed by a confirming stimulation test if basal serum calcitonin is showed to be high, is the most currently recommended approach, but questions concerning cost-benefit and possibility of diagnosis error make the validity of this recommendation discussible. |
| first_indexed | 2024-04-13T17:16:49Z |
| format | Article |
| id | doaj.art-ade7023289e4475db9359c6e6e51aa5c |
| institution | Directory Open Access Journal |
| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-04-13T17:16:49Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-ade7023289e4475db9359c6e6e51aa5c2022-12-22T02:38:06ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002013-01-0117352452810.4103/2230-8210.111677False positive results using calcitonin as a screening method for medullary thyroid carcinomaRafael Loch BatistaAndrea Cecilia ToscaniniLenine Garcia BrandãoMalebranche Berardo C Cunha-NetoThe role of serum calcitonin as part of the evaluation of thyroid nodules has been widely discussed in literature. However there still is no consensus of measurement of calcitonin in the initial evaluation of a patient with thyroid nodule. Problems concerning cost-benefit, lab methods, false positive and low prevalence of medullary thyroid carcinoma (MTC) are factors that limit this approach. We have illustrated two cases where serum calcitonin was used in the evaluation of thyroid nodule and rates proved to be high. A stimulation test was performed, using calcium as secretagogue, and calcitonin hyper-stimulation was confirmed, but anatomopathologic examination did not evidence medullar neoplasia. Anatomopathologic diagnosis detected Hashimoto thyroiditis in one case and adenomatous goiter plus an occult papillary thyroid carcinoma in the other one. Recommendation for routine use of serum calcitonin in the initial diagnostic evaluation of a thyroid nodule, followed by a confirming stimulation test if basal serum calcitonin is showed to be high, is the most currently recommended approach, but questions concerning cost-benefit and possibility of diagnosis error make the validity of this recommendation discussible.http://www.ijem.in/article.asp?issn=2230-8210;year=2013;volume=17;issue=3;spage=524;epage=528;aulast=BatistaCalcitonincarcinomamedullarythyroid diseases |
| spellingShingle | Rafael Loch Batista Andrea Cecilia Toscanini Lenine Garcia Brandão Malebranche Berardo C Cunha-Neto False positive results using calcitonin as a screening method for medullary thyroid carcinoma Indian Journal of Endocrinology and Metabolism Calcitonin carcinoma medullary thyroid diseases |
| title | False positive results using calcitonin as a screening method for medullary thyroid carcinoma |
| title_full | False positive results using calcitonin as a screening method for medullary thyroid carcinoma |
| title_fullStr | False positive results using calcitonin as a screening method for medullary thyroid carcinoma |
| title_full_unstemmed | False positive results using calcitonin as a screening method for medullary thyroid carcinoma |
| title_short | False positive results using calcitonin as a screening method for medullary thyroid carcinoma |
| title_sort | false positive results using calcitonin as a screening method for medullary thyroid carcinoma |
| topic | Calcitonin carcinoma medullary thyroid diseases |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2013;volume=17;issue=3;spage=524;epage=528;aulast=Batista |
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