Current and Future Approaches to Classify VUSs in LGMD-Related Genes

Current and Future Approaches to Classify VUSs in LGMD-Related Genes

Next-generation sequencing (NGS) has revealed large numbers of genetic variants in LGMD-related genes, with most of them classified as variants of uncertain significance (VUSs). VUSs are genetic changes with unknown pathological impact and present a major challenge in genetic test interpretation and...

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Bibliographic Details
Main Authors:	Chengcheng Li, Gabe Haller, Conrad C. Weihl
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Series:	Genes
Subjects:	LGMD sarcoglycan high-throughput screening deep mutational scanning
Online Access:	https://www.mdpi.com/2073-4425/13/2/382

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