Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease
Parkinson’s disease (PD) is caused by the degeneration of dopaminergic neurons due to an accumulation of intraneuronal abnormal alpha-synuclein (α-syn) protein aggregates. It has been reported that the levels of exosomal α-syn of neuronal origin in plasma correlate significantly with motor dysfuncti...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-02-01
|
| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2022.805087/full |
| _version_ | 1818294266496024576 |
|---|---|
| author | Denisse Sepúlveda Denisse Sepúlveda Denisse Sepúlveda Marisol Cisternas-Olmedo Marisol Cisternas-Olmedo Marisol Cisternas-Olmedo Javiera Arcos Javiera Arcos Javiera Arcos Melissa Nassif Melissa Nassif René L. Vidal René L. Vidal René L. Vidal |
| author_facet | Denisse Sepúlveda Denisse Sepúlveda Denisse Sepúlveda Marisol Cisternas-Olmedo Marisol Cisternas-Olmedo Marisol Cisternas-Olmedo Javiera Arcos Javiera Arcos Javiera Arcos Melissa Nassif Melissa Nassif René L. Vidal René L. Vidal René L. Vidal |
| author_sort | Denisse Sepúlveda |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is caused by the degeneration of dopaminergic neurons due to an accumulation of intraneuronal abnormal alpha-synuclein (α-syn) protein aggregates. It has been reported that the levels of exosomal α-syn of neuronal origin in plasma correlate significantly with motor dysfunction, highlighting the exosomes containing α-syn as a potential biomarker of PD. In addition, it has been found that the selective autophagy-lysosomal pathway (ALP) contributes to the secretion of misfolded proteins involved in neurodegenerative diseases. In this review, we describe the evidence that supports the relationship between the ALP and α-syn exosomal secretion on the PD progression and its implications in the diagnosis and progression of this pathology. |
| first_indexed | 2024-12-13T03:29:01Z |
| format | Article |
| id | doaj.art-ade956d219374b4fbaa3c4d8f20d7362 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-13T03:29:01Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-ade956d219374b4fbaa3c4d8f20d73622022-12-22T00:01:12ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992022-02-011510.3389/fnmol.2022.805087805087Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s DiseaseDenisse Sepúlveda0Denisse Sepúlveda1Denisse Sepúlveda2Marisol Cisternas-Olmedo3Marisol Cisternas-Olmedo4Marisol Cisternas-Olmedo5Javiera Arcos6Javiera Arcos7Javiera Arcos8Melissa Nassif9Melissa Nassif10René L. Vidal11René L. Vidal12René L. Vidal13Center for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago, ChileBiomedical Neuroscience Institute, University of Chile, Santiago, ChileGeroscience Center for Brain Health and Metabolism, Santiago, ChileCenter for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago, ChileBiomedical Neuroscience Institute, University of Chile, Santiago, ChileGeroscience Center for Brain Health and Metabolism, Santiago, ChileCenter for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago, ChileBiomedical Neuroscience Institute, University of Chile, Santiago, ChileGeroscience Center for Brain Health and Metabolism, Santiago, ChileCenter for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago, ChileEscuela de Biotecnología, Facultad de Ciencias, Universidad Mayor, Santiago, ChileCenter for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago, ChileBiomedical Neuroscience Institute, University of Chile, Santiago, ChileGeroscience Center for Brain Health and Metabolism, Santiago, ChileParkinson’s disease (PD) is caused by the degeneration of dopaminergic neurons due to an accumulation of intraneuronal abnormal alpha-synuclein (α-syn) protein aggregates. It has been reported that the levels of exosomal α-syn of neuronal origin in plasma correlate significantly with motor dysfunction, highlighting the exosomes containing α-syn as a potential biomarker of PD. In addition, it has been found that the selective autophagy-lysosomal pathway (ALP) contributes to the secretion of misfolded proteins involved in neurodegenerative diseases. In this review, we describe the evidence that supports the relationship between the ALP and α-syn exosomal secretion on the PD progression and its implications in the diagnosis and progression of this pathology.https://www.frontiersin.org/articles/10.3389/fnmol.2022.805087/fullautophagy-lysosomal pathwayα-syn exosomal secretionParkinson’s disease progressionbiomarkerdegradation |
| spellingShingle | Denisse Sepúlveda Denisse Sepúlveda Denisse Sepúlveda Marisol Cisternas-Olmedo Marisol Cisternas-Olmedo Marisol Cisternas-Olmedo Javiera Arcos Javiera Arcos Javiera Arcos Melissa Nassif Melissa Nassif René L. Vidal René L. Vidal René L. Vidal Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease Frontiers in Molecular Neuroscience autophagy-lysosomal pathway α-syn exosomal secretion Parkinson’s disease progression biomarker degradation |
| title | Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease |
| title_full | Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease |
| title_fullStr | Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease |
| title_full_unstemmed | Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease |
| title_short | Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease |
| title_sort | contribution of autophagy lysosomal pathway in the exosomal secretion of alpha synuclein and its impact in the progression of parkinson s disease |
| topic | autophagy-lysosomal pathway α-syn exosomal secretion Parkinson’s disease progression biomarker degradation |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2022.805087/full |
| work_keys_str_mv | AT denissesepulveda contributionofautophagylysosomalpathwayintheexosomalsecretionofalphasynucleinanditsimpactintheprogressionofparkinsonsdisease AT denissesepulveda contributionofautophagylysosomalpathwayintheexosomalsecretionofalphasynucleinanditsimpactintheprogressionofparkinsonsdisease AT denissesepulveda contributionofautophagylysosomalpathwayintheexosomalsecretionofalphasynucleinanditsimpactintheprogressionofparkinsonsdisease AT marisolcisternasolmedo contributionofautophagylysosomalpathwayintheexosomalsecretionofalphasynucleinanditsimpactintheprogressionofparkinsonsdisease AT marisolcisternasolmedo contributionofautophagylysosomalpathwayintheexosomalsecretionofalphasynucleinanditsimpactintheprogressionofparkinsonsdisease AT marisolcisternasolmedo contributionofautophagylysosomalpathwayintheexosomalsecretionofalphasynucleinanditsimpactintheprogressionofparkinsonsdisease AT javieraarcos contributionofautophagylysosomalpathwayintheexosomalsecretionofalphasynucleinanditsimpactintheprogressionofparkinsonsdisease AT javieraarcos contributionofautophagylysosomalpathwayintheexosomalsecretionofalphasynucleinanditsimpactintheprogressionofparkinsonsdisease AT javieraarcos contributionofautophagylysosomalpathwayintheexosomalsecretionofalphasynucleinanditsimpactintheprogressionofparkinsonsdisease AT melissanassif contributionofautophagylysosomalpathwayintheexosomalsecretionofalphasynucleinanditsimpactintheprogressionofparkinsonsdisease AT melissanassif contributionofautophagylysosomalpathwayintheexosomalsecretionofalphasynucleinanditsimpactintheprogressionofparkinsonsdisease AT renelvidal contributionofautophagylysosomalpathwayintheexosomalsecretionofalphasynucleinanditsimpactintheprogressionofparkinsonsdisease AT renelvidal contributionofautophagylysosomalpathwayintheexosomalsecretionofalphasynucleinanditsimpactintheprogressionofparkinsonsdisease AT renelvidal contributionofautophagylysosomalpathwayintheexosomalsecretionofalphasynucleinanditsimpactintheprogressionofparkinsonsdisease |