Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease

Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease

Parkinson’s disease (PD) is caused by the degeneration of dopaminergic neurons due to an accumulation of intraneuronal abnormal alpha-synuclein (α-syn) protein aggregates. It has been reported that the levels of exosomal α-syn of neuronal origin in plasma correlate significantly with motor dysfuncti...

Full description

Bibliographic Details
Main Authors: Denisse Sepúlveda, Marisol Cisternas-Olmedo, Javiera Arcos, Melissa Nassif, René L. Vidal
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
autophagy-lysosomal pathway
α-syn exosomal secretion
Parkinson’s disease progression
biomarker
degradation
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.805087/full

Similar Items

Similar Items