IP<sub>3</sub>R-Mediated Calcium Release Promotes Ferroptotic Death in SH-SY5Y Neuroblastoma Cells

IP<sub>3</sub>R-Mediated Calcium Release Promotes Ferroptotic Death in SH-SY5Y Neuroblastoma Cells

Ferroptosis is an iron-dependent cell death pathway that involves the depletion of intracellular glutathione (GSH) levels and iron-mediated lipid peroxidation. Ferroptosis is experimentally caused by the inhibition of the cystine/glutamate antiporter xCT, which depletes cells of GSH, or by inhibitio...

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Bibliographic Details
Main Authors: Joaquín Campos, Silvia Gleitze, Cecilia Hidalgo, Marco T. Núñez
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Antioxidants
Subjects:
cell death
ferroptosis
calcium signaling
reactive oxygen species
endoplasmic reticulum
lipid peroxidation
Online Access:https://www.mdpi.com/2076-3921/13/2/196

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