Effect of exogenous transcription factors integration sites on safety and pluripotency of induced pluripotent stem cells

Effect of exogenous transcription factors integration sites on safety and pluripotency of induced pluripotent stem cells

Induced pluripotent stem cells (iPSCs), generated from somatic cells, not only possess similar characteristics with embryonic stem cells (ESCs), but also present more advantages than ESCs in medical applications. The classical induction method that utilizes the integration of exogenous genes into ch...

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Bibliographic Details
Main Authors: Yin S, Li W, Yang G, Cheng Y, Yi Q, Fan S, Ma Q, Zeng F
Format: Article
Language:English
Published: Sciendo 2020-08-01
Series:Balkan Journal of Medical Genetics
Subjects:
induced pluripotent stem cells (ipscs)
integration sites
pluripotency
safety
tetraploid complementation
Online Access:https://doi.org/10.2478/bjmg-2020-0003

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