Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment Control
Generating the desired solute concentration signal in micro-environments is vital to many applications ranging from micromixing to analyzing cellular response to a dynamic microenvironment. We propose a new modular design to generate targeted temporally varying concentration signals in microfluidic...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/13/5/774 |
| _version_ | 1797497790611324928 |
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| author | Bowen Ling Ilenia Battiato |
| author_facet | Bowen Ling Ilenia Battiato |
| author_sort | Bowen Ling |
| collection | DOAJ |
| description | Generating the desired solute concentration signal in micro-environments is vital to many applications ranging from micromixing to analyzing cellular response to a dynamic microenvironment. We propose a new modular design to generate targeted temporally varying concentration signals in microfluidic systems while minimizing perturbations to the flow field. The modularized design, here referred to as module-fluidics, similar in principle to interlocking toy bricks, is constructed from a combination of two building blocks and allows one to achieve versatility and flexibility in dynamically controlling input concentration. The building blocks are an oscillator and an integrator, and their combination enables the creation of controlled and complex concentration signals, with different user-defined time-scales. We show two basic connection patterns, in-series and in-parallel, to test the generation, integration, sampling and superposition of temporally-varying signals. All such signals can be fully characterized by analytic functions, in analogy with electric circuits, and allow one to perform design and optimization before fabrication. Such modularization offers a versatile and promising platform that allows one to create highly customizable time-dependent concentration inputs which can be targeted to the specific application of interest. |
| first_indexed | 2024-03-10T03:24:19Z |
| format | Article |
| id | doaj.art-aded3eb01a544718a90dc157566e7ba6 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T03:24:19Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-aded3eb01a544718a90dc157566e7ba62023-11-23T12:12:59ZengMDPI AGMicromachines2072-666X2022-05-0113577410.3390/mi13050774Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment ControlBowen Ling0Ilenia Battiato1Energy Resource Engineering, Stanford University, Stanford, CA 94305, USAEnergy Resource Engineering, Stanford University, Stanford, CA 94305, USAGenerating the desired solute concentration signal in micro-environments is vital to many applications ranging from micromixing to analyzing cellular response to a dynamic microenvironment. We propose a new modular design to generate targeted temporally varying concentration signals in microfluidic systems while minimizing perturbations to the flow field. The modularized design, here referred to as module-fluidics, similar in principle to interlocking toy bricks, is constructed from a combination of two building blocks and allows one to achieve versatility and flexibility in dynamically controlling input concentration. The building blocks are an oscillator and an integrator, and their combination enables the creation of controlled and complex concentration signals, with different user-defined time-scales. We show two basic connection patterns, in-series and in-parallel, to test the generation, integration, sampling and superposition of temporally-varying signals. All such signals can be fully characterized by analytic functions, in analogy with electric circuits, and allow one to perform design and optimization before fabrication. Such modularization offers a versatile and promising platform that allows one to create highly customizable time-dependent concentration inputs which can be targeted to the specific application of interest.https://www.mdpi.com/2072-666X/13/5/774mircofluidicsmicromodelmicrofluidic valve |
| spellingShingle | Bowen Ling Ilenia Battiato Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment Control Micromachines mircofluidics micromodel microfluidic valve |
| title | Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment Control |
| title_full | Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment Control |
| title_fullStr | Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment Control |
| title_full_unstemmed | Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment Control |
| title_short | Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment Control |
| title_sort | module fluidics building blocks for spatio temporal microenvironment control |
| topic | mircofluidics micromodel microfluidic valve |
| url | https://www.mdpi.com/2072-666X/13/5/774 |
| work_keys_str_mv | AT bowenling modulefluidicsbuildingblocksforspatiotemporalmicroenvironmentcontrol AT ileniabattiato modulefluidicsbuildingblocksforspatiotemporalmicroenvironmentcontrol |