A systematic review protocol of timing, efficacy and cost effectiveness of upper limb therapy for motor recovery post-stroke
Abstract Background Improving upper limb (UL) motor recovery after stroke represents a major clinical and scientific goal. We aim to complete three systematic reviews to estimate the (1) association between time to start of UL therapy and motor recovery, (2) relative efficacy of different UL therapy...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-07-01
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| Series: | Systematic Reviews |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13643-019-1093-6 |
| _version_ | 1818849937502240768 |
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| author | Kathryn S. Hayward Sharon F. Kramer Vincent Thijs Julie Ratcliffe Nick S. Ward Leonid Churilov Laura Jolliffe Dale Corbett Geoffrey Cloud Tina Kaffenberger Amy Brodtmann Julie Bernhardt Natasha A. Lannin |
| author_facet | Kathryn S. Hayward Sharon F. Kramer Vincent Thijs Julie Ratcliffe Nick S. Ward Leonid Churilov Laura Jolliffe Dale Corbett Geoffrey Cloud Tina Kaffenberger Amy Brodtmann Julie Bernhardt Natasha A. Lannin |
| author_sort | Kathryn S. Hayward |
| collection | DOAJ |
| description | Abstract Background Improving upper limb (UL) motor recovery after stroke represents a major clinical and scientific goal. We aim to complete three systematic reviews to estimate the (1) association between time to start of UL therapy and motor recovery, (2) relative efficacy of different UL therapy approaches post-stroke and (3) cost-effectiveness of UL therapy interventions. Methods We have designed a systematic review protocol to address three systematic review questions that were each registered with PROSPERO. The search will be conducted in MEDLINE, EMBASE, and Cochrane Controlled Register of Trials. We will include randomised controlled trials, non-randomised clinical trials, before-after studies and observational studies of adult stroke survivors with an average stroke onset < 6 months, undergoing hospital-based therapy to improve UL function. Eligible interventions will aim to promote UL functional recovery. Two reviewers will independently screen, select and extract data. Study risk of bias will be appraised using appropriate tools. Clinical measures of motor recovery will be investigated (primary measure Fugl Meyer UL assessment), as well as measures of health-related quality of life (primary measure EQ-5D) and all cost-effectiveness analyses completed. Secondary outcomes include therapy dose (minutes, weeks, repetitions as available) and safety (i.e. adverse events, serious adverse events). A narrative synthesis will describe quality and content of the evidence. If feasible, we will conduct random effects meta-analyses where appropriate. Discussion We anticipate the findings of this review will increase our understanding of UL therapy and inform the generation of novel, data-driven hypotheses for future UL therapy research post-stroke. Systematic review registration PROSPERO, http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42018019367, http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42018111629, http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42018111628. |
| first_indexed | 2024-12-19T06:41:10Z |
| format | Article |
| id | doaj.art-adf1cfb078244e4fbd45ad96de10b5c3 |
| institution | Directory Open Access Journal |
| issn | 2046-4053 |
| language | English |
| last_indexed | 2024-12-19T06:41:10Z |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Systematic Reviews |
| spelling | doaj.art-adf1cfb078244e4fbd45ad96de10b5c32022-12-21T20:32:04ZengBMCSystematic Reviews2046-40532019-07-01811810.1186/s13643-019-1093-6A systematic review protocol of timing, efficacy and cost effectiveness of upper limb therapy for motor recovery post-strokeKathryn S. Hayward0Sharon F. Kramer1Vincent Thijs2Julie Ratcliffe3Nick S. Ward4Leonid Churilov5Laura Jolliffe6Dale Corbett7Geoffrey Cloud8Tina Kaffenberger9Amy Brodtmann10Julie Bernhardt11Natasha A. Lannin12Melbourne School of Health Sciences, University of MelbourneAVERT Early Rehabilitation Research Group, Stroke Theme, Florey Institute of Neuroscience and Mental HealthStroke Theme, Florey Institute of Neuroscience and Mental Health and Neurology Department, Austin HealthCollege of Nursing and Health Sciences, Flinders UniversityUCL Institute of Neurology and The National Hospital for Neurology and NeurosurgeryNHMRC CRE in Stroke Rehabilitation and Brain Recovery, University of MelbourneCollege of Science, Health and Engineering, La Trobe UniversityDepartment of Cellular and Molecular Medicine, University of Ottawa and Canadian Partnership for Stroke RecoveryDepartment of Neurology, Alfred HealthAVERT Early Rehabilitation Research Group, Stroke Theme, Florey Institute of Neuroscience and Mental HealthMelbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental HealthAVERT Early Rehabilitation Research Group, Stroke Theme, Florey Institute of Neuroscience and Mental HealthOccupational Therapy Department, Alfred HealthAbstract Background Improving upper limb (UL) motor recovery after stroke represents a major clinical and scientific goal. We aim to complete three systematic reviews to estimate the (1) association between time to start of UL therapy and motor recovery, (2) relative efficacy of different UL therapy approaches post-stroke and (3) cost-effectiveness of UL therapy interventions. Methods We have designed a systematic review protocol to address three systematic review questions that were each registered with PROSPERO. The search will be conducted in MEDLINE, EMBASE, and Cochrane Controlled Register of Trials. We will include randomised controlled trials, non-randomised clinical trials, before-after studies and observational studies of adult stroke survivors with an average stroke onset < 6 months, undergoing hospital-based therapy to improve UL function. Eligible interventions will aim to promote UL functional recovery. Two reviewers will independently screen, select and extract data. Study risk of bias will be appraised using appropriate tools. Clinical measures of motor recovery will be investigated (primary measure Fugl Meyer UL assessment), as well as measures of health-related quality of life (primary measure EQ-5D) and all cost-effectiveness analyses completed. Secondary outcomes include therapy dose (minutes, weeks, repetitions as available) and safety (i.e. adverse events, serious adverse events). A narrative synthesis will describe quality and content of the evidence. If feasible, we will conduct random effects meta-analyses where appropriate. Discussion We anticipate the findings of this review will increase our understanding of UL therapy and inform the generation of novel, data-driven hypotheses for future UL therapy research post-stroke. Systematic review registration PROSPERO, http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42018019367, http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42018111629, http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42018111628.http://link.springer.com/article/10.1186/s13643-019-1093-6StrokeUpper limbSystematic reviewProtocolTherapyRehabilitation |
| spellingShingle | Kathryn S. Hayward Sharon F. Kramer Vincent Thijs Julie Ratcliffe Nick S. Ward Leonid Churilov Laura Jolliffe Dale Corbett Geoffrey Cloud Tina Kaffenberger Amy Brodtmann Julie Bernhardt Natasha A. Lannin A systematic review protocol of timing, efficacy and cost effectiveness of upper limb therapy for motor recovery post-stroke Systematic Reviews Stroke Upper limb Systematic review Protocol Therapy Rehabilitation |
| title | A systematic review protocol of timing, efficacy and cost effectiveness of upper limb therapy for motor recovery post-stroke |
| title_full | A systematic review protocol of timing, efficacy and cost effectiveness of upper limb therapy for motor recovery post-stroke |
| title_fullStr | A systematic review protocol of timing, efficacy and cost effectiveness of upper limb therapy for motor recovery post-stroke |
| title_full_unstemmed | A systematic review protocol of timing, efficacy and cost effectiveness of upper limb therapy for motor recovery post-stroke |
| title_short | A systematic review protocol of timing, efficacy and cost effectiveness of upper limb therapy for motor recovery post-stroke |
| title_sort | systematic review protocol of timing efficacy and cost effectiveness of upper limb therapy for motor recovery post stroke |
| topic | Stroke Upper limb Systematic review Protocol Therapy Rehabilitation |
| url | http://link.springer.com/article/10.1186/s13643-019-1093-6 |
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