A mathematical model for predicting and controlling COVID-19 transmission with impulsive vaccination
This study examines an epidemiological model known as the susceptible-exposed-infected-hospitalized-recovered (SEIHR) model, with and without impulsive vaccination strategies. First, the model was analyzed without impulsive vaccination in the presence of a reinfection effect. Subsequently, it was st...
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| Format: | Article |
| Language: | English |
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AIMS Press
2024-02-01
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| Series: | AIMS Mathematics |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/math.2024306?viewType=HTML |
| _version_ | 1797299778764144640 |
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| author | Chontita Rattanakul Inthira Chaiya |
| author_facet | Chontita Rattanakul Inthira Chaiya |
| author_sort | Chontita Rattanakul |
| collection | DOAJ |
| description | This study examines an epidemiological model known as the susceptible-exposed-infected-hospitalized-recovered (SEIHR) model, with and without impulsive vaccination strategies. First, the model was analyzed without impulsive vaccination in the presence of a reinfection effect. Subsequently, it was studied as part of a periodic impulsive vaccination strategy targeting the susceptible population. These vaccination impulses were administered in very brief intervals at specific time instants, with a fixed time gap between each impulse. The two approaches can be modified to respond to different amounts of susceptibility, with control efforts intensifying as susceptibility levels rise. The model's analysis includes crucial aspects such as the non-negativity of solutions, the existence of steady states, and the stability corresponding to the basic reproduction number. We demonstrate that when vaccination measures are taken into account, the basic reproduction number remains as less than one. Therefore, the disease-free equilibrium in the case of vaccination could still be asymptotically stable at the higher disease transmission rate, as compared to the case of no vaccination in which the disease-free equilibrium may no longer be asymptotically stable. Furthermore, we show that when the disease-free equilibrium is stable, the endemic equilibrium cannot be attained, and that when the reproduction number rises above unity, the disease-free equilibrium becomes unstable while the endemic equilibrium becomes stable. We have also derived conditions for the global stability of both equilibriums. To support our theoretical results, we have constructed a time series of numerical simulations and compared them with real-world data from the ongoing SARS-CoV-2 (COVID-19) pandemic. |
| first_indexed | 2024-03-07T22:56:34Z |
| format | Article |
| id | doaj.art-adf204175ae84c4ba80b01a001f08aab |
| institution | Directory Open Access Journal |
| issn | 2473-6988 |
| language | English |
| last_indexed | 2024-03-07T22:56:34Z |
| publishDate | 2024-02-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Mathematics |
| spelling | doaj.art-adf204175ae84c4ba80b01a001f08aab2024-02-23T01:30:46ZengAIMS PressAIMS Mathematics2473-69882024-02-01936281630410.3934/math.2024306A mathematical model for predicting and controlling COVID-19 transmission with impulsive vaccinationChontita Rattanakul0Inthira Chaiya11. Department of Mathematics, Faculty of Science, Mahidol University, Bangkok 10400, Thailand 2. Centre of Excellence in Mathematics, MHESI, Bangkok 10400, Thailand3. Department of Mathematics, Faculty of Science, Mahasarakham University, Mahasarakham 44150, ThailandThis study examines an epidemiological model known as the susceptible-exposed-infected-hospitalized-recovered (SEIHR) model, with and without impulsive vaccination strategies. First, the model was analyzed without impulsive vaccination in the presence of a reinfection effect. Subsequently, it was studied as part of a periodic impulsive vaccination strategy targeting the susceptible population. These vaccination impulses were administered in very brief intervals at specific time instants, with a fixed time gap between each impulse. The two approaches can be modified to respond to different amounts of susceptibility, with control efforts intensifying as susceptibility levels rise. The model's analysis includes crucial aspects such as the non-negativity of solutions, the existence of steady states, and the stability corresponding to the basic reproduction number. We demonstrate that when vaccination measures are taken into account, the basic reproduction number remains as less than one. Therefore, the disease-free equilibrium in the case of vaccination could still be asymptotically stable at the higher disease transmission rate, as compared to the case of no vaccination in which the disease-free equilibrium may no longer be asymptotically stable. Furthermore, we show that when the disease-free equilibrium is stable, the endemic equilibrium cannot be attained, and that when the reproduction number rises above unity, the disease-free equilibrium becomes unstable while the endemic equilibrium becomes stable. We have also derived conditions for the global stability of both equilibriums. To support our theoretical results, we have constructed a time series of numerical simulations and compared them with real-world data from the ongoing SARS-CoV-2 (COVID-19) pandemic.https://www.aimspress.com/article/doi/10.3934/math.2024306?viewType=HTMLmathematical modelperiodic impulsive vaccinationcovid-19epidemic modelstability |
| spellingShingle | Chontita Rattanakul Inthira Chaiya A mathematical model for predicting and controlling COVID-19 transmission with impulsive vaccination AIMS Mathematics mathematical model periodic impulsive vaccination covid-19 epidemic model stability |
| title | A mathematical model for predicting and controlling COVID-19 transmission with impulsive vaccination |
| title_full | A mathematical model for predicting and controlling COVID-19 transmission with impulsive vaccination |
| title_fullStr | A mathematical model for predicting and controlling COVID-19 transmission with impulsive vaccination |
| title_full_unstemmed | A mathematical model for predicting and controlling COVID-19 transmission with impulsive vaccination |
| title_short | A mathematical model for predicting and controlling COVID-19 transmission with impulsive vaccination |
| title_sort | mathematical model for predicting and controlling covid 19 transmission with impulsive vaccination |
| topic | mathematical model periodic impulsive vaccination covid-19 epidemic model stability |
| url | https://www.aimspress.com/article/doi/10.3934/math.2024306?viewType=HTML |
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