Investigations of the CLOCK and BMAL1 Proteins Binding to DNA: A Molecular Dynamics Simulation Study.
The circadian locomotor output cycles kaput (CLOCK), and brain and muscle ARNT-like 1 (BMAL1) proteins are important transcriptional factors of the endogenous circadian clock. The CLOCK and BMAL1 proteins can regulate the transcription-translation activities of the clock-related genes through the DN...
Main Authors: | Tuo Xue, Chunnian Song, Qing Wang, Yan Wang, Guangju Chen |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4859532?pdf=render |
Similar Items
-
Prediction of mammalian tissue-specific CLOCK–BMAL1 binding to E-box DNA motifs
by: Daniel Marri, et al.
Published: (2023-05-01) -
Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice
by: Kazuhiro Shimomura, et al.
Published: (2013-04-01) -
Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex.
by: Valérie Mongrain, et al.
Published: (2011-01-01) -
Regulation of circadian clock transcriptional output by CLOCK:BMAL1.
by: Alexandra J Trott, et al.
Published: (2018-01-01) -
NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1.
by: Yang Shen, et al.
Published: (2021-11-01)