Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45.
Hydrogen peroxide induces oxidation and consequently inactivation of many protein tyrosine phosphatases. It was found that hydrogen peroxide, in the presence of carboxylic acids, was efficiently activated to form even more potent oxidant - peroxy acid. We have found that peroxytetradecanoic acid dec...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300686/pdf/?tool=EBI |
| _version_ | 1818389004572164096 |
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| author | Alicja Kuban-Jankowska Jack A Tuszynski Philip Winter Magdalena Gorska Narcyz Knap Michal Wozniak |
| author_facet | Alicja Kuban-Jankowska Jack A Tuszynski Philip Winter Magdalena Gorska Narcyz Knap Michal Wozniak |
| author_sort | Alicja Kuban-Jankowska |
| collection | DOAJ |
| description | Hydrogen peroxide induces oxidation and consequently inactivation of many protein tyrosine phosphatases. It was found that hydrogen peroxide, in the presence of carboxylic acids, was efficiently activated to form even more potent oxidant - peroxy acid. We have found that peroxytetradecanoic acid decreases the enzymatic activity of CD45 phosphatase significantly more than hydrogen peroxide. Our molecular docking computational analysis suggests that peroxytetradecanoic acid has a higher binding affinity to the catalytic center of CD45 than hydrogen peroxide. |
| first_indexed | 2024-12-14T04:34:50Z |
| format | Article |
| id | doaj.art-adf6ddcd969d42ac88d4b352b029f390 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T04:34:50Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-adf6ddcd969d42ac88d4b352b029f3902022-12-21T23:17:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5249510.1371/journal.pone.0052495Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45.Alicja Kuban-JankowskaJack A TuszynskiPhilip WinterMagdalena GorskaNarcyz KnapMichal WozniakHydrogen peroxide induces oxidation and consequently inactivation of many protein tyrosine phosphatases. It was found that hydrogen peroxide, in the presence of carboxylic acids, was efficiently activated to form even more potent oxidant - peroxy acid. We have found that peroxytetradecanoic acid decreases the enzymatic activity of CD45 phosphatase significantly more than hydrogen peroxide. Our molecular docking computational analysis suggests that peroxytetradecanoic acid has a higher binding affinity to the catalytic center of CD45 than hydrogen peroxide.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300686/pdf/?tool=EBI |
| spellingShingle | Alicja Kuban-Jankowska Jack A Tuszynski Philip Winter Magdalena Gorska Narcyz Knap Michal Wozniak Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45. PLoS ONE |
| title | Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45. |
| title_full | Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45. |
| title_fullStr | Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45. |
| title_full_unstemmed | Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45. |
| title_short | Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45. |
| title_sort | activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase cd45 |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300686/pdf/?tool=EBI |
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