Sulfur-Containing Metabolites from Marine and Terrestrial Fungal Sources: Origin, Structures, and Bioactivities
Organosulfur natural products (NPs) refer to the different kinds of small molecular-containing sulfur (S) elements. Sulfur-containing NPs tightly link to the biochemical processes and play an important role in the pharmaceutical industry. The majority of S-containing NPs are generally isolated from...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/20/12/765 |
| _version_ | 1797456610198552576 |
|---|---|
| author | Zhaoming Liu Mingqiong Li Shuo Wang Huibin Huang Weimin Zhang |
| author_facet | Zhaoming Liu Mingqiong Li Shuo Wang Huibin Huang Weimin Zhang |
| author_sort | Zhaoming Liu |
| collection | DOAJ |
| description | Organosulfur natural products (NPs) refer to the different kinds of small molecular-containing sulfur (S) elements. Sulfur-containing NPs tightly link to the biochemical processes and play an important role in the pharmaceutical industry. The majority of S-containing NPs are generally isolated from Alliaceae plants or bacteria, and those from fungi are still relatively rare. In recent years, an increasing number of S-containing metabolites have been discovered in marine and terrestrial fungi, but there is no comprehensive and targeted review to summarize the studies. In order to make it more straightforward to better grasp the fungal-derived S-containing NPs and understand the particularity of marine S-containing NPs compared to those from terrestrial fungi, we summarized the chemical structures and biological activities of 89 new fungal-derived S-containing metabolites from 1929 when the penicillin was discovered to the present in this current review. The structural and bioactive diversity of these S-containing metabolites were concluded in detail, and the preliminary mechanism for C-S bond formation in fungi was also discussed briefly. |
| first_indexed | 2024-03-09T16:10:17Z |
| format | Article |
| id | doaj.art-adfc9738402f41d0b824d1464f059a85 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T16:10:17Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-adfc9738402f41d0b824d1464f059a852023-11-24T16:19:49ZengMDPI AGMarine Drugs1660-33972022-12-01201276510.3390/md20120765Sulfur-Containing Metabolites from Marine and Terrestrial Fungal Sources: Origin, Structures, and BioactivitiesZhaoming Liu0Mingqiong Li1Shuo Wang2Huibin Huang3Weimin Zhang4State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu District, Guangzhou 510070, ChinaState Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu District, Guangzhou 510070, ChinaState Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu District, Guangzhou 510070, ChinaState Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu District, Guangzhou 510070, ChinaState Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu District, Guangzhou 510070, ChinaOrganosulfur natural products (NPs) refer to the different kinds of small molecular-containing sulfur (S) elements. Sulfur-containing NPs tightly link to the biochemical processes and play an important role in the pharmaceutical industry. The majority of S-containing NPs are generally isolated from Alliaceae plants or bacteria, and those from fungi are still relatively rare. In recent years, an increasing number of S-containing metabolites have been discovered in marine and terrestrial fungi, but there is no comprehensive and targeted review to summarize the studies. In order to make it more straightforward to better grasp the fungal-derived S-containing NPs and understand the particularity of marine S-containing NPs compared to those from terrestrial fungi, we summarized the chemical structures and biological activities of 89 new fungal-derived S-containing metabolites from 1929 when the penicillin was discovered to the present in this current review. The structural and bioactive diversity of these S-containing metabolites were concluded in detail, and the preliminary mechanism for C-S bond formation in fungi was also discussed briefly.https://www.mdpi.com/1660-3397/20/12/765sulfur-containing natural productsfungichemical structuresbioactivities |
| spellingShingle | Zhaoming Liu Mingqiong Li Shuo Wang Huibin Huang Weimin Zhang Sulfur-Containing Metabolites from Marine and Terrestrial Fungal Sources: Origin, Structures, and Bioactivities Marine Drugs sulfur-containing natural products fungi chemical structures bioactivities |
| title | Sulfur-Containing Metabolites from Marine and Terrestrial Fungal Sources: Origin, Structures, and Bioactivities |
| title_full | Sulfur-Containing Metabolites from Marine and Terrestrial Fungal Sources: Origin, Structures, and Bioactivities |
| title_fullStr | Sulfur-Containing Metabolites from Marine and Terrestrial Fungal Sources: Origin, Structures, and Bioactivities |
| title_full_unstemmed | Sulfur-Containing Metabolites from Marine and Terrestrial Fungal Sources: Origin, Structures, and Bioactivities |
| title_short | Sulfur-Containing Metabolites from Marine and Terrestrial Fungal Sources: Origin, Structures, and Bioactivities |
| title_sort | sulfur containing metabolites from marine and terrestrial fungal sources origin structures and bioactivities |
| topic | sulfur-containing natural products fungi chemical structures bioactivities |
| url | https://www.mdpi.com/1660-3397/20/12/765 |
| work_keys_str_mv | AT zhaomingliu sulfurcontainingmetabolitesfrommarineandterrestrialfungalsourcesoriginstructuresandbioactivities AT mingqiongli sulfurcontainingmetabolitesfrommarineandterrestrialfungalsourcesoriginstructuresandbioactivities AT shuowang sulfurcontainingmetabolitesfrommarineandterrestrialfungalsourcesoriginstructuresandbioactivities AT huibinhuang sulfurcontainingmetabolitesfrommarineandterrestrialfungalsourcesoriginstructuresandbioactivities AT weiminzhang sulfurcontainingmetabolitesfrommarineandterrestrialfungalsourcesoriginstructuresandbioactivities |