Incorporating oral, inhalation and dermal bioaccessibility into human health risk characterization following exposure to Chromated Copper Arsenate (CCA)-contaminated soils
Exposure to potentially toxic metal(loid)s (PTMs) in soil may happen via ingestion, inhalation, and dermal pathway. A more accurate risk characterization should consider PTM bioavailability. Using ten soil samples collected in the Montreal area (Canada) near CCA-treated utility poles, this study aim...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651322012866 |
| _version_ | 1797961298698305536 |
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| author | Carlos A. Marin Villegas Gerald J. Zagury |
| author_facet | Carlos A. Marin Villegas Gerald J. Zagury |
| author_sort | Carlos A. Marin Villegas |
| collection | DOAJ |
| description | Exposure to potentially toxic metal(loid)s (PTMs) in soil may happen via ingestion, inhalation, and dermal pathway. A more accurate risk characterization should consider PTM bioavailability. Using ten soil samples collected in the Montreal area (Canada) near CCA-treated utility poles, this study aims to characterize non-carcinogenic and carcinogenic human health risks associated with As, Cr, Cu, Pb, and Zn through a multi-pathway exposure approach. This innovative study incorporates, for the first time, the bioaccessible fraction of the metal(loid)s for three exposure routes and two different scenarios. For the residential and industrial scenarios, the oral and dermal pathways yielded a hazard index (HI) much higher than 1 with and without bioaccessibility considerations (range 1.7 – 349 without bioaccessibility and 0.8–134 with bioaccessibility), whereas the inhalation pathway caused a lower hazard (HI < 1). For the dermal pathway, the hazard quotient was higher when bioaccessibility of field-collected samples was considered due to inherent assumptions from the US EPA soil approach to calculate the dermal dose. For carcinogenic risk, As and Pb were the most significant contributors to risk for the oral pathway, followed by the same elements for the dermal pathway. The overall carcinogenic risk was higher than the acceptable risk ( > 10−4) with and without bioaccessibility considerations (range 1.9E-4 – 9.6E-3 without bioaccessibility and 6.8E-5 – 3.8E-3 with bioaccessibility). Bioaccessibility tests provide a more accurate assessment of exposure to PTMs compared to total concentrations in soils. |
| first_indexed | 2024-04-11T00:56:48Z |
| format | Article |
| id | doaj.art-adff0311dd98434fa8f11efd0d0f219a |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-11T00:56:48Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-adff0311dd98434fa8f11efd0d0f219a2023-01-05T04:30:45ZengElsevierEcotoxicology and Environmental Safety0147-65132023-01-01249114446Incorporating oral, inhalation and dermal bioaccessibility into human health risk characterization following exposure to Chromated Copper Arsenate (CCA)-contaminated soilsCarlos A. Marin Villegas0Gerald J. Zagury1Department of Civil, Geological and Mining Engineering, Polytechnique Montréal, Montreal, QC H3C 3A7, CanadaCorresponding author.; Department of Civil, Geological and Mining Engineering, Polytechnique Montréal, Montreal, QC H3C 3A7, CanadaExposure to potentially toxic metal(loid)s (PTMs) in soil may happen via ingestion, inhalation, and dermal pathway. A more accurate risk characterization should consider PTM bioavailability. Using ten soil samples collected in the Montreal area (Canada) near CCA-treated utility poles, this study aims to characterize non-carcinogenic and carcinogenic human health risks associated with As, Cr, Cu, Pb, and Zn through a multi-pathway exposure approach. This innovative study incorporates, for the first time, the bioaccessible fraction of the metal(loid)s for three exposure routes and two different scenarios. For the residential and industrial scenarios, the oral and dermal pathways yielded a hazard index (HI) much higher than 1 with and without bioaccessibility considerations (range 1.7 – 349 without bioaccessibility and 0.8–134 with bioaccessibility), whereas the inhalation pathway caused a lower hazard (HI < 1). For the dermal pathway, the hazard quotient was higher when bioaccessibility of field-collected samples was considered due to inherent assumptions from the US EPA soil approach to calculate the dermal dose. For carcinogenic risk, As and Pb were the most significant contributors to risk for the oral pathway, followed by the same elements for the dermal pathway. The overall carcinogenic risk was higher than the acceptable risk ( > 10−4) with and without bioaccessibility considerations (range 1.9E-4 – 9.6E-3 without bioaccessibility and 6.8E-5 – 3.8E-3 with bioaccessibility). Bioaccessibility tests provide a more accurate assessment of exposure to PTMs compared to total concentrations in soils.http://www.sciencedirect.com/science/article/pii/S0147651322012866Multi-pathway exposureMetal(loid) pollutionIn-vitro bioaccessibilityHuman health exposure assessmentHuman health risk assessment |
| spellingShingle | Carlos A. Marin Villegas Gerald J. Zagury Incorporating oral, inhalation and dermal bioaccessibility into human health risk characterization following exposure to Chromated Copper Arsenate (CCA)-contaminated soils Ecotoxicology and Environmental Safety Multi-pathway exposure Metal(loid) pollution In-vitro bioaccessibility Human health exposure assessment Human health risk assessment |
| title | Incorporating oral, inhalation and dermal bioaccessibility into human health risk characterization following exposure to Chromated Copper Arsenate (CCA)-contaminated soils |
| title_full | Incorporating oral, inhalation and dermal bioaccessibility into human health risk characterization following exposure to Chromated Copper Arsenate (CCA)-contaminated soils |
| title_fullStr | Incorporating oral, inhalation and dermal bioaccessibility into human health risk characterization following exposure to Chromated Copper Arsenate (CCA)-contaminated soils |
| title_full_unstemmed | Incorporating oral, inhalation and dermal bioaccessibility into human health risk characterization following exposure to Chromated Copper Arsenate (CCA)-contaminated soils |
| title_short | Incorporating oral, inhalation and dermal bioaccessibility into human health risk characterization following exposure to Chromated Copper Arsenate (CCA)-contaminated soils |
| title_sort | incorporating oral inhalation and dermal bioaccessibility into human health risk characterization following exposure to chromated copper arsenate cca contaminated soils |
| topic | Multi-pathway exposure Metal(loid) pollution In-vitro bioaccessibility Human health exposure assessment Human health risk assessment |
| url | http://www.sciencedirect.com/science/article/pii/S0147651322012866 |
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