Regulation of Cholesterol Metabolism by Bioactive Components of Soy Proteins: Novel Translational Evidence
Hypercholesterolemia represents one key pathophysiological factor predisposing to increasing risk of developing cardiovascular disease worldwide. Controlling plasma cholesterol levels and other metabolic risk factors is of paramount importance to prevent the overall burden of disease emerging from c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/1/227 |
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| author | Giusy Rita Caponio David Q.-H. Wang Agostino Di Ciaula Maria De Angelis Piero Portincasa |
| author_facet | Giusy Rita Caponio David Q.-H. Wang Agostino Di Ciaula Maria De Angelis Piero Portincasa |
| author_sort | Giusy Rita Caponio |
| collection | DOAJ |
| description | Hypercholesterolemia represents one key pathophysiological factor predisposing to increasing risk of developing cardiovascular disease worldwide. Controlling plasma cholesterol levels and other metabolic risk factors is of paramount importance to prevent the overall burden of disease emerging from cardiovascular-disease-related morbidity and mortality. Dietary cholesterol undergoes micellization and absorption in the small intestine, transport via blood, and uptake in the liver. An important amount of cholesterol originates from hepatic synthesis, and is secreted by the liver into bile together with bile acids (BA) and phospholipids, with all forming micelles and vesicles. In clinical medicine, dietary recommendations play a key role together with pharmacological interventions to counteract the adverse effects of chronic hypercholesterolemia. Bioactive compounds may also be part of initial dietary plans. Specifically, soybean contains proteins and peptides with biological activity on plasma cholesterol levels and this property makes soy proteins a functional food. Here, we discuss how soy proteins modulate lipid metabolism and reduce plasma cholesterol concentrations in humans, with potential outcomes in improving metabolic- and dyslipidemia-related conditions. |
| first_indexed | 2024-03-10T13:42:53Z |
| format | Article |
| id | doaj.art-ae00f60da99948749db8605f7448b6b3 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:42:53Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ae00f60da99948749db8605f7448b6b32023-11-21T02:51:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-0122122710.3390/ijms22010227Regulation of Cholesterol Metabolism by Bioactive Components of Soy Proteins: Novel Translational EvidenceGiusy Rita Caponio0David Q.-H. Wang1Agostino Di Ciaula2Maria De Angelis3Piero Portincasa4Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, via Amendola 165/a, 70126 Bari, ItalyDepartment of Medicine and Genetics, Division of Gastroenterology and Liver Diseases, Marion Bessin Liver Research Center, Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USADivision of Internal Medicine Clinica Medica “A. Murri”, Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, 70124 Bari, ItalyDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, via Amendola 165/a, 70126 Bari, ItalyDivision of Internal Medicine Clinica Medica “A. Murri”, Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, 70124 Bari, ItalyHypercholesterolemia represents one key pathophysiological factor predisposing to increasing risk of developing cardiovascular disease worldwide. Controlling plasma cholesterol levels and other metabolic risk factors is of paramount importance to prevent the overall burden of disease emerging from cardiovascular-disease-related morbidity and mortality. Dietary cholesterol undergoes micellization and absorption in the small intestine, transport via blood, and uptake in the liver. An important amount of cholesterol originates from hepatic synthesis, and is secreted by the liver into bile together with bile acids (BA) and phospholipids, with all forming micelles and vesicles. In clinical medicine, dietary recommendations play a key role together with pharmacological interventions to counteract the adverse effects of chronic hypercholesterolemia. Bioactive compounds may also be part of initial dietary plans. Specifically, soybean contains proteins and peptides with biological activity on plasma cholesterol levels and this property makes soy proteins a functional food. Here, we discuss how soy proteins modulate lipid metabolism and reduce plasma cholesterol concentrations in humans, with potential outcomes in improving metabolic- and dyslipidemia-related conditions.https://www.mdpi.com/1422-0067/22/1/227cholesterolsoybeanproteinshealthcardiovascular diseases |
| spellingShingle | Giusy Rita Caponio David Q.-H. Wang Agostino Di Ciaula Maria De Angelis Piero Portincasa Regulation of Cholesterol Metabolism by Bioactive Components of Soy Proteins: Novel Translational Evidence International Journal of Molecular Sciences cholesterol soybean proteins health cardiovascular diseases |
| title | Regulation of Cholesterol Metabolism by Bioactive Components of Soy Proteins: Novel Translational Evidence |
| title_full | Regulation of Cholesterol Metabolism by Bioactive Components of Soy Proteins: Novel Translational Evidence |
| title_fullStr | Regulation of Cholesterol Metabolism by Bioactive Components of Soy Proteins: Novel Translational Evidence |
| title_full_unstemmed | Regulation of Cholesterol Metabolism by Bioactive Components of Soy Proteins: Novel Translational Evidence |
| title_short | Regulation of Cholesterol Metabolism by Bioactive Components of Soy Proteins: Novel Translational Evidence |
| title_sort | regulation of cholesterol metabolism by bioactive components of soy proteins novel translational evidence |
| topic | cholesterol soybean proteins health cardiovascular diseases |
| url | https://www.mdpi.com/1422-0067/22/1/227 |
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