New technology in experimental neurobiology: neuronal networks coupled with multielectrode array
Multielectrode arraуs (MEA) as the recording and stimulatingsystem for self-organizing, functionally heterogeneous neuronalnetwork formed by developing CNS cells in vitro is a new, uniquetechnology for investigation of mechanisms of pathological neurodestructiveprocesses and for searching the means...
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2017-02-01
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| Series: | Анналы клинической и экспериментальной неврологии |
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| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/340/247 |
| _version_ | 1811337905563500544 |
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| author | I. V. Mukhina L. G. Khaspekov |
| author_facet | I. V. Mukhina L. G. Khaspekov |
| author_sort | I. V. Mukhina |
| collection | DOAJ |
| description | Multielectrode arraуs (MEA) as the recording and stimulatingsystem for self-organizing, functionally heterogeneous neuronalnetwork formed by developing CNS cells in vitro is a new, uniquetechnology for investigation of mechanisms of pathological neurodestructiveprocesses and for searching the means of their pharmacological corrections. The principal advantages of the MEAare the precise noninvasive long-term network stimulation andmeasurement of the electric signals, pharmacological testing anddrug screening, optical structural and functional imaging ofmetabolic ionic current into neurons and glial cells using confocallaser scanning microscopy. The brain cells and tissues coupledin vitro with MEA enables neuroprotective and/or neurotoxicdrug testing in different models of the central nervous systempathological states. Data-intensive part, good reproducibility andquantitative assessment capability make it possible to relate theneuron networks cultured to the MEA with biosensors, allowingto perform effective pharmacological screening in vitro for themodels of ischemia, trauma, epilepsy, Alzheimers disease, etc. |
| first_indexed | 2024-04-13T18:02:51Z |
| format | Article |
| id | doaj.art-ae0164dfde48476794c391c01b05529c |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-04-13T18:02:51Z |
| publishDate | 2017-02-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-ae0164dfde48476794c391c01b05529c2022-12-22T02:36:11ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332017-02-0142445110.17816/psaic340247New technology in experimental neurobiology: neuronal networks coupled with multielectrode arrayI. V. Mukhina0L. G. Khaspekov1Nizhny Novgorod State Medical Academy (Nizhny Novgorod)Research Centre of Neurology, Russian Academy of Medical Sciences (Moscow)Multielectrode arraуs (MEA) as the recording and stimulatingsystem for self-organizing, functionally heterogeneous neuronalnetwork formed by developing CNS cells in vitro is a new, uniquetechnology for investigation of mechanisms of pathological neurodestructiveprocesses and for searching the means of their pharmacological corrections. The principal advantages of the MEAare the precise noninvasive long-term network stimulation andmeasurement of the electric signals, pharmacological testing anddrug screening, optical structural and functional imaging ofmetabolic ionic current into neurons and glial cells using confocallaser scanning microscopy. The brain cells and tissues coupledin vitro with MEA enables neuroprotective and/or neurotoxicdrug testing in different models of the central nervous systempathological states. Data-intensive part, good reproducibility andquantitative assessment capability make it possible to relate theneuron networks cultured to the MEA with biosensors, allowingto perform effective pharmacological screening in vitro for themodels of ischemia, trauma, epilepsy, Alzheimers disease, etc.https://annaly-nevrologii.com/journal/pathID/article/viewFile/340/247multielectrode arraybrain cell and tissue culturesneuronal network in vitrobiosensordrug screeningneurodegenerarive disorders |
| spellingShingle | I. V. Mukhina L. G. Khaspekov New technology in experimental neurobiology: neuronal networks coupled with multielectrode array Анналы клинической и экспериментальной неврологии multielectrode array brain cell and tissue cultures neuronal network in vitro biosensor drug screening neurodegenerarive disorders |
| title | New technology in experimental neurobiology: neuronal networks coupled with multielectrode array |
| title_full | New technology in experimental neurobiology: neuronal networks coupled with multielectrode array |
| title_fullStr | New technology in experimental neurobiology: neuronal networks coupled with multielectrode array |
| title_full_unstemmed | New technology in experimental neurobiology: neuronal networks coupled with multielectrode array |
| title_short | New technology in experimental neurobiology: neuronal networks coupled with multielectrode array |
| title_sort | new technology in experimental neurobiology neuronal networks coupled with multielectrode array |
| topic | multielectrode array brain cell and tissue cultures neuronal network in vitro biosensor drug screening neurodegenerarive disorders |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/340/247 |
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