Altered basal ganglia network integration in schizophrenia

Altered basal ganglia network integration in schizophrenia

The basal ganglia involve in a range of functions which are disturbed in schizophrenia. This study decomposed the resting-state data of 28 schizophrenia patients and 31 healthy controls with spatial independent component analysis and identified increased functional connectivity in the bilateral caud...

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Bibliographic Details
Main Authors: Mingjun eDuan, Xi eChen, Hui eHe, Yuchao eJiang, Sisi eJiang, Qiankun eXie, Yongxiu eLai, Cheng eLuo, Dezhong eYao
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Human Neuroscience
Subjects:
Schizophrenia
functional connectivity
Independent Component Analysis
Resting-state fMRI
Basal Ganglia network
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00561/full
Description
Summary:The basal ganglia involve in a range of functions which are disturbed in schizophrenia. This study decomposed the resting-state data of 28 schizophrenia patients and 31 healthy controls with spatial independent component analysis and identified increased functional connectivity in the bilateral caudate nucleus in schizophrenia. Further, the caudate nucleus in schizophrenia showed altered functional connection with the prefrontal area and cerebellum. These results identified the importance of basal ganglia in schizophrenia. Clinical Trial Registration: Chinese Clinical Trial Registry. Registration number. ChiCTR-RCS-14004878.
ISSN:1662-5161

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