Altered basal ganglia network integration in schizophrenia
The basal ganglia involve in a range of functions which are disturbed in schizophrenia. This study decomposed the resting-state data of 28 schizophrenia patients and 31 healthy controls with spatial independent component analysis and identified increased functional connectivity in the bilateral caud...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-10-01
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| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00561/full |
| _version_ | 1819087596579454976 |
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| author | Mingjun eDuan Mingjun eDuan Xi eChen Hui eHe Yuchao eJiang Sisi eJiang Qiankun eXie Yongxiu eLai Cheng eLuo Dezhong eYao |
| author_facet | Mingjun eDuan Mingjun eDuan Xi eChen Hui eHe Yuchao eJiang Sisi eJiang Qiankun eXie Yongxiu eLai Cheng eLuo Dezhong eYao |
| author_sort | Mingjun eDuan |
| collection | DOAJ |
| description | The basal ganglia involve in a range of functions which are disturbed in schizophrenia. This study decomposed the resting-state data of 28 schizophrenia patients and 31 healthy controls with spatial independent component analysis and identified increased functional connectivity in the bilateral caudate nucleus in schizophrenia. Further, the caudate nucleus in schizophrenia showed altered functional connection with the prefrontal area and cerebellum. These results identified the importance of basal ganglia in schizophrenia. Clinical Trial Registration: Chinese Clinical Trial Registry. Registration number. ChiCTR-RCS-14004878. |
| first_indexed | 2024-12-21T21:38:40Z |
| format | Article |
| id | doaj.art-ae01e393ed1447cfa6e9fdc75c403cad |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-21T21:38:40Z |
| publishDate | 2015-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-ae01e393ed1447cfa6e9fdc75c403cad2022-12-21T18:49:25ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612015-10-01910.3389/fnhum.2015.00561155644Altered basal ganglia network integration in schizophreniaMingjun eDuan0Mingjun eDuan1Xi eChen2Hui eHe3Yuchao eJiang4Sisi eJiang5Qiankun eXie6Yongxiu eLai7Cheng eLuo8Dezhong eYao9Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of ChinaThe Fourth People’s Hospital ChengduKey Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of ChinaKey Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of ChinaKey Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of ChinaKey Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of ChinaKey Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of ChinaKey Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of ChinaKey Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of ChinaKey Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of ChinaThe basal ganglia involve in a range of functions which are disturbed in schizophrenia. This study decomposed the resting-state data of 28 schizophrenia patients and 31 healthy controls with spatial independent component analysis and identified increased functional connectivity in the bilateral caudate nucleus in schizophrenia. Further, the caudate nucleus in schizophrenia showed altered functional connection with the prefrontal area and cerebellum. These results identified the importance of basal ganglia in schizophrenia. Clinical Trial Registration: Chinese Clinical Trial Registry. Registration number. ChiCTR-RCS-14004878.http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00561/fullSchizophreniafunctional connectivityIndependent Component AnalysisResting-state fMRIBasal Ganglia network |
| spellingShingle | Mingjun eDuan Mingjun eDuan Xi eChen Hui eHe Yuchao eJiang Sisi eJiang Qiankun eXie Yongxiu eLai Cheng eLuo Dezhong eYao Altered basal ganglia network integration in schizophrenia Frontiers in Human Neuroscience Schizophrenia functional connectivity Independent Component Analysis Resting-state fMRI Basal Ganglia network |
| title | Altered basal ganglia network integration in schizophrenia |
| title_full | Altered basal ganglia network integration in schizophrenia |
| title_fullStr | Altered basal ganglia network integration in schizophrenia |
| title_full_unstemmed | Altered basal ganglia network integration in schizophrenia |
| title_short | Altered basal ganglia network integration in schizophrenia |
| title_sort | altered basal ganglia network integration in schizophrenia |
| topic | Schizophrenia functional connectivity Independent Component Analysis Resting-state fMRI Basal Ganglia network |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00561/full |
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