Role of Iron and Iron Overload in the Pathogenesis of Invasive Fungal Infections in Patients with Hematological Malignancies
Iron is an essential trace metal necessary for the reproduction and survival of fungal pathogens. The latter have developed various mechanisms to acquire iron from their mammalian hosts, with whom they participate in a continuous struggle for dominance over iron. Invasive fungal infections are an im...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/15/4457 |
| _version_ | 1797413471045812224 |
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| author | Toni Valković Marija Stanić Damić |
| author_facet | Toni Valković Marija Stanić Damić |
| author_sort | Toni Valković |
| collection | DOAJ |
| description | Iron is an essential trace metal necessary for the reproduction and survival of fungal pathogens. The latter have developed various mechanisms to acquire iron from their mammalian hosts, with whom they participate in a continuous struggle for dominance over iron. Invasive fungal infections are an important problem in the treatment of patients with hematological malignancies, and they are associated with significant morbidity and mortality. The diagnosis of invasive clinical infections in these patients is complex, and the treatment, which must occur as early as possible, is difficult. There are several studies that have shown a possible link between iron overload and an increased susceptibility to infections. This link is also relevant for patients with hematological malignancies and for those treated with allogeneic hematopoietic stem cell transplantation. The role of iron and its metabolism in the virulence and pathogenesis of various invasive fungal infections is intriguing, and so far, there is some evidence linking invasive fungal infections to iron or iron overload. Clarifying the possible association of iron and iron overload with susceptibility to invasive fungal infections could be important for a better prevention and treatment of these infections in patients with hematological malignancies. |
| first_indexed | 2024-03-09T05:18:24Z |
| format | Article |
| id | doaj.art-ae038b72ad1747deb7b0a95f5431b398 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T05:18:24Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-ae038b72ad1747deb7b0a95f5431b3982023-12-03T12:43:19ZengMDPI AGJournal of Clinical Medicine2077-03832022-07-011115445710.3390/jcm11154457Role of Iron and Iron Overload in the Pathogenesis of Invasive Fungal Infections in Patients with Hematological MalignanciesToni Valković0Marija Stanić Damić1Department of Hematology, University Hospital Rijeka, Krešimirova 42, 51000 Rijeka, CroatiaDepartment of Hematology, University Hospital Rijeka, Krešimirova 42, 51000 Rijeka, CroatiaIron is an essential trace metal necessary for the reproduction and survival of fungal pathogens. The latter have developed various mechanisms to acquire iron from their mammalian hosts, with whom they participate in a continuous struggle for dominance over iron. Invasive fungal infections are an important problem in the treatment of patients with hematological malignancies, and they are associated with significant morbidity and mortality. The diagnosis of invasive clinical infections in these patients is complex, and the treatment, which must occur as early as possible, is difficult. There are several studies that have shown a possible link between iron overload and an increased susceptibility to infections. This link is also relevant for patients with hematological malignancies and for those treated with allogeneic hematopoietic stem cell transplantation. The role of iron and its metabolism in the virulence and pathogenesis of various invasive fungal infections is intriguing, and so far, there is some evidence linking invasive fungal infections to iron or iron overload. Clarifying the possible association of iron and iron overload with susceptibility to invasive fungal infections could be important for a better prevention and treatment of these infections in patients with hematological malignancies.https://www.mdpi.com/2077-0383/11/15/4457ironiron overloadfungal infectionhematological malignanciesiron chelation therapy |
| spellingShingle | Toni Valković Marija Stanić Damić Role of Iron and Iron Overload in the Pathogenesis of Invasive Fungal Infections in Patients with Hematological Malignancies Journal of Clinical Medicine iron iron overload fungal infection hematological malignancies iron chelation therapy |
| title | Role of Iron and Iron Overload in the Pathogenesis of Invasive Fungal Infections in Patients with Hematological Malignancies |
| title_full | Role of Iron and Iron Overload in the Pathogenesis of Invasive Fungal Infections in Patients with Hematological Malignancies |
| title_fullStr | Role of Iron and Iron Overload in the Pathogenesis of Invasive Fungal Infections in Patients with Hematological Malignancies |
| title_full_unstemmed | Role of Iron and Iron Overload in the Pathogenesis of Invasive Fungal Infections in Patients with Hematological Malignancies |
| title_short | Role of Iron and Iron Overload in the Pathogenesis of Invasive Fungal Infections in Patients with Hematological Malignancies |
| title_sort | role of iron and iron overload in the pathogenesis of invasive fungal infections in patients with hematological malignancies |
| topic | iron iron overload fungal infection hematological malignancies iron chelation therapy |
| url | https://www.mdpi.com/2077-0383/11/15/4457 |
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