Effect of Metals on Kinetic Pathways of Amyloid-β Aggregation

Metal ions, including copper and zinc, have been implicated in the pathogenesis of Alzheimer’s disease through a variety of mechanisms including increased amyloid-β affinity and redox effects. Recent reports have demonstrated that the amyloid-β monomer does not necessarily travel through a definitiv...

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Bibliographic Details
Main Authors: Francis Hane, Zoya Leonenko
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:Biomolecules
Subjects:
Online Access:http://www.mdpi.com/2218-273X/4/1/101