Aberrantly higher functional connectivity in the salience network is associated with transient global amnesia
Abstract Triple intrinsic brain networks including the salience network (SN), default mode network (DMN), and central executive network (CEN), are known to be important in human cognition. Therefore, investigating those intrinsic brain networks in transient global amnesia (TGA) may offer novel insig...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-97842-y |
| _version_ | 1819292677369233408 |
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| author | Geon Ha Kim Bori R. Kim Min Young Chun Kee Duk Park Soo Mee Lim Jee Hyang Jeong |
| author_facet | Geon Ha Kim Bori R. Kim Min Young Chun Kee Duk Park Soo Mee Lim Jee Hyang Jeong |
| author_sort | Geon Ha Kim |
| collection | DOAJ |
| description | Abstract Triple intrinsic brain networks including the salience network (SN), default mode network (DMN), and central executive network (CEN), are known to be important in human cognition. Therefore, investigating those intrinsic brain networks in transient global amnesia (TGA) may offer novel insight useful for the pathophysiology of TGA. Fifty TGA patients underwent the resting state functional magnetic resonance imaging (rsfMRI) within 24 h, at 72 h, and 3 months after TGA onset. Twenty-five age, gender matched controls also underwent rsfMRI. Within 24 h of TGA onset, TGA patients showed greater functional connectivity in the SN and lower functional connectivity in the DMN, while relatively preserved functional connectivity was observed in the CEN. Interestingly, TGA patients continued to show decreased connectivity in the DMN, while no alterations were shown in the SN 72 h after illness onset. Three months after TGA onset, alterations of functional connectivity in the SN or the DMN were normalized. Our findings suggest that TGA is associated with transient greater functional connectivity in the SN and lower connectivity in the DMN. |
| first_indexed | 2024-12-24T03:58:20Z |
| format | Article |
| id | doaj.art-ae045e09171d4b4a807f3bc7b863c863 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-24T03:58:20Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-ae045e09171d4b4a807f3bc7b863c8632022-12-21T17:16:24ZengNature PortfolioScientific Reports2045-23222021-10-0111111210.1038/s41598-021-97842-yAberrantly higher functional connectivity in the salience network is associated with transient global amnesiaGeon Ha Kim0Bori R. Kim1Min Young Chun2Kee Duk Park3Soo Mee Lim4Jee Hyang Jeong5Department of Neurology, College of Medicine, Ewha Womans University Mokdong Hospital, Ewha Womans UniversityDepartment of Neurology, College of Medicine, Ewha Womans University Mokdong Hospital, Ewha Womans UniversityDepartment of Neurology, College of Medicine, Ewha Womans University Mokdong Hospital, Ewha Womans UniversityDepartment of Neurology, College of Medicine, Ewha Womans University Mokdong Hospital, Ewha Womans UniversityDepartment of Radiology, Ewha Womans University Seoul Hospital, Ewha Womans University College of MedicineDepartment of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of MedicineAbstract Triple intrinsic brain networks including the salience network (SN), default mode network (DMN), and central executive network (CEN), are known to be important in human cognition. Therefore, investigating those intrinsic brain networks in transient global amnesia (TGA) may offer novel insight useful for the pathophysiology of TGA. Fifty TGA patients underwent the resting state functional magnetic resonance imaging (rsfMRI) within 24 h, at 72 h, and 3 months after TGA onset. Twenty-five age, gender matched controls also underwent rsfMRI. Within 24 h of TGA onset, TGA patients showed greater functional connectivity in the SN and lower functional connectivity in the DMN, while relatively preserved functional connectivity was observed in the CEN. Interestingly, TGA patients continued to show decreased connectivity in the DMN, while no alterations were shown in the SN 72 h after illness onset. Three months after TGA onset, alterations of functional connectivity in the SN or the DMN were normalized. Our findings suggest that TGA is associated with transient greater functional connectivity in the SN and lower connectivity in the DMN.https://doi.org/10.1038/s41598-021-97842-y |
| spellingShingle | Geon Ha Kim Bori R. Kim Min Young Chun Kee Duk Park Soo Mee Lim Jee Hyang Jeong Aberrantly higher functional connectivity in the salience network is associated with transient global amnesia Scientific Reports |
| title | Aberrantly higher functional connectivity in the salience network is associated with transient global amnesia |
| title_full | Aberrantly higher functional connectivity in the salience network is associated with transient global amnesia |
| title_fullStr | Aberrantly higher functional connectivity in the salience network is associated with transient global amnesia |
| title_full_unstemmed | Aberrantly higher functional connectivity in the salience network is associated with transient global amnesia |
| title_short | Aberrantly higher functional connectivity in the salience network is associated with transient global amnesia |
| title_sort | aberrantly higher functional connectivity in the salience network is associated with transient global amnesia |
| url | https://doi.org/10.1038/s41598-021-97842-y |
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