Milk Protein Adsorption on Metallic Iron Surfaces
Food processing and consumption involves multiple contacts between biological fluids and solid materials of processing devices, of which steel is one of the most common. Due to the complexity of these interactions, it is difficult to identify the main control factors in the formation of undesirable...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
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| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/13/12/1857 |
| _version_ | 1797593264736436224 |
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| author | Parinaz Mosaddeghi Amini Julia Subbotina Vladimir Lobaskin |
| author_facet | Parinaz Mosaddeghi Amini Julia Subbotina Vladimir Lobaskin |
| author_sort | Parinaz Mosaddeghi Amini |
| collection | DOAJ |
| description | Food processing and consumption involves multiple contacts between biological fluids and solid materials of processing devices, of which steel is one of the most common. Due to the complexity of these interactions, it is difficult to identify the main control factors in the formation of undesirable deposits on the device surfaces that may affect safety and efficiency of the processes. Mechanistic understanding of biomolecule–metal interactions involving food proteins could improve management of these pertinent industrial processes and consumer safety in the food industry and beyond. In this work, we perform a multiscale study of the formation of protein corona on iron surfaces and nanoparticles in contact with cow milk proteins. By calculating the binding energies of proteins with the substrate, we quantify the adsorption strength and rank proteins by the adsorption affinity. We use a multiscale method involving all-atom and coarse-grained simulations based on generated ab initio three-dimensional structures of milk proteins for this purpose. Finally, using the adsorption energy results, we predict the composition of protein corona on iron curved and flat surfaces via a competitive adsorption model. |
| first_indexed | 2024-03-11T02:05:34Z |
| format | Article |
| id | doaj.art-ae05d9fd10254d8db094f30253622a30 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-11T02:05:34Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-ae05d9fd10254d8db094f30253622a302023-11-18T11:53:51ZengMDPI AGNanomaterials2079-49912023-06-011312185710.3390/nano13121857Milk Protein Adsorption on Metallic Iron SurfacesParinaz Mosaddeghi Amini0Julia Subbotina1Vladimir Lobaskin2School of Physics, University College Dublin, Dublin 4, D04 V1W8 Dublin, IrelandSchool of Physics, University College Dublin, Dublin 4, D04 V1W8 Dublin, IrelandSchool of Physics, University College Dublin, Dublin 4, D04 V1W8 Dublin, IrelandFood processing and consumption involves multiple contacts between biological fluids and solid materials of processing devices, of which steel is one of the most common. Due to the complexity of these interactions, it is difficult to identify the main control factors in the formation of undesirable deposits on the device surfaces that may affect safety and efficiency of the processes. Mechanistic understanding of biomolecule–metal interactions involving food proteins could improve management of these pertinent industrial processes and consumer safety in the food industry and beyond. In this work, we perform a multiscale study of the formation of protein corona on iron surfaces and nanoparticles in contact with cow milk proteins. By calculating the binding energies of proteins with the substrate, we quantify the adsorption strength and rank proteins by the adsorption affinity. We use a multiscale method involving all-atom and coarse-grained simulations based on generated ab initio three-dimensional structures of milk proteins for this purpose. Finally, using the adsorption energy results, we predict the composition of protein corona on iron curved and flat surfaces via a competitive adsorption model.https://www.mdpi.com/2079-4991/13/12/1857nanoparticlepotential of mean forceprotein adsorptionprotein coronabio–nano interfacemultiscale modeling |
| spellingShingle | Parinaz Mosaddeghi Amini Julia Subbotina Vladimir Lobaskin Milk Protein Adsorption on Metallic Iron Surfaces Nanomaterials nanoparticle potential of mean force protein adsorption protein corona bio–nano interface multiscale modeling |
| title | Milk Protein Adsorption on Metallic Iron Surfaces |
| title_full | Milk Protein Adsorption on Metallic Iron Surfaces |
| title_fullStr | Milk Protein Adsorption on Metallic Iron Surfaces |
| title_full_unstemmed | Milk Protein Adsorption on Metallic Iron Surfaces |
| title_short | Milk Protein Adsorption on Metallic Iron Surfaces |
| title_sort | milk protein adsorption on metallic iron surfaces |
| topic | nanoparticle potential of mean force protein adsorption protein corona bio–nano interface multiscale modeling |
| url | https://www.mdpi.com/2079-4991/13/12/1857 |
| work_keys_str_mv | AT parinazmosaddeghiamini milkproteinadsorptiononmetallicironsurfaces AT juliasubbotina milkproteinadsorptiononmetallicironsurfaces AT vladimirlobaskin milkproteinadsorptiononmetallicironsurfaces |