Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease
Neopterin (NPT), a pyrazino-pyrimidine compound mainly produced by activated macrophages, has been regarded as a proinflammatory and proatherosclerotic agent. The study was designed to evaluate NPT level and its interaction with conventional peripheral artery disease (PAD) biomarkers and vascular re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/10/1911 |
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| author | Agnieszka Zembron-Lacny Wioletta Dziubek Anna Tylutka Eryk Wacka Barbara Morawin Katarzyna Bulinska Malgorzata Stefanska Marek Wozniewski Andrzej Szuba |
| author_facet | Agnieszka Zembron-Lacny Wioletta Dziubek Anna Tylutka Eryk Wacka Barbara Morawin Katarzyna Bulinska Malgorzata Stefanska Marek Wozniewski Andrzej Szuba |
| author_sort | Agnieszka Zembron-Lacny |
| collection | DOAJ |
| description | Neopterin (NPT), a pyrazino-pyrimidine compound mainly produced by activated macrophages, has been regarded as a proinflammatory and proatherosclerotic agent. The study was designed to evaluate NPT level and its interaction with conventional peripheral artery disease (PAD) biomarkers and vascular regenerative potential in severe PAD. The study included 59 patients (females <i>n</i> = 17, males <i>n</i> = 42) aged 67.0 ± 8.2 years classified into two groups based on ankle-brachial index (ABI) measurements (ABI ≤ 0.9 <i>n</i> = 43, ABI ≤ 0.5 <i>n</i> = 16). A total of 60 subjects aged 70.4 ± 5.5 years (females <i>n</i> = 42, males <i>n</i> = 18) with ABI > 0.9 constituted a reference group. NPT concentration reached values above 10 nmol/L in patients with PAD, which differed significantly from reference group (8.15 ± 1.33 nmol/L). High levels of CRP > 5 mg/L, TC > 200 mg/dL as well as lipoproteins LDL > 100 mg/dL and non-HDL > 130 mg/dL were found in the same group, indicating the relationship between NPT and conventional atherogenic markers. The endothelial progenitor cells (EPCs) tended toward lower values in patients with ABI ≤ 0.5 when compared to reference group, and inversely correlated with NPT. These findings indicate a crucial role of NPT in atheromatous process and its usefulness in monitoring PAD severity. However, the role of NPT in chronic PAD needs further studies including relatively high number of subjects. |
| first_indexed | 2024-03-10T06:37:49Z |
| format | Article |
| id | doaj.art-ae0620b05eea4f808aeb2b2bc1cc6255 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T06:37:49Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-ae0620b05eea4f808aeb2b2bc1cc62552023-11-22T17:58:42ZengMDPI AGDiagnostics2075-44182021-10-011110191110.3390/diagnostics11101911Assessment of Serum Neopterin as a Biomarker in Peripheral Artery DiseaseAgnieszka Zembron-Lacny0Wioletta Dziubek1Anna Tylutka2Eryk Wacka3Barbara Morawin4Katarzyna Bulinska5Malgorzata Stefanska6Marek Wozniewski7Andrzej Szuba8Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, 65-417 Zielona Gora, PolandFaculty of Physiotherapy, University School of Physical Education in Wroclaw, 51-612 Wroclaw, PolandDepartment of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, 65-417 Zielona Gora, PolandCollegium Medicum, University of Zielona Gora, 65-417 Zielona Gora, PolandDepartment of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, 65-417 Zielona Gora, PolandFaculty of Physiotherapy, University School of Physical Education in Wroclaw, 51-612 Wroclaw, PolandFaculty of Physiotherapy, University School of Physical Education in Wroclaw, 51-612 Wroclaw, PolandFaculty of Physiotherapy, University School of Physical Education in Wroclaw, 51-612 Wroclaw, PolandDepartment of Angiology, Hypertension and Diabetology Medical University Wroclaw, 50-556 Wroclaw, PolandNeopterin (NPT), a pyrazino-pyrimidine compound mainly produced by activated macrophages, has been regarded as a proinflammatory and proatherosclerotic agent. The study was designed to evaluate NPT level and its interaction with conventional peripheral artery disease (PAD) biomarkers and vascular regenerative potential in severe PAD. The study included 59 patients (females <i>n</i> = 17, males <i>n</i> = 42) aged 67.0 ± 8.2 years classified into two groups based on ankle-brachial index (ABI) measurements (ABI ≤ 0.9 <i>n</i> = 43, ABI ≤ 0.5 <i>n</i> = 16). A total of 60 subjects aged 70.4 ± 5.5 years (females <i>n</i> = 42, males <i>n</i> = 18) with ABI > 0.9 constituted a reference group. NPT concentration reached values above 10 nmol/L in patients with PAD, which differed significantly from reference group (8.15 ± 1.33 nmol/L). High levels of CRP > 5 mg/L, TC > 200 mg/dL as well as lipoproteins LDL > 100 mg/dL and non-HDL > 130 mg/dL were found in the same group, indicating the relationship between NPT and conventional atherogenic markers. The endothelial progenitor cells (EPCs) tended toward lower values in patients with ABI ≤ 0.5 when compared to reference group, and inversely correlated with NPT. These findings indicate a crucial role of NPT in atheromatous process and its usefulness in monitoring PAD severity. However, the role of NPT in chronic PAD needs further studies including relatively high number of subjects.https://www.mdpi.com/2075-4418/11/10/1911inflammationnitro-oxidative stressendothelial progenitor cellshematopoietic progenitor cellsphysical performance |
| spellingShingle | Agnieszka Zembron-Lacny Wioletta Dziubek Anna Tylutka Eryk Wacka Barbara Morawin Katarzyna Bulinska Malgorzata Stefanska Marek Wozniewski Andrzej Szuba Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease Diagnostics inflammation nitro-oxidative stress endothelial progenitor cells hematopoietic progenitor cells physical performance |
| title | Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease |
| title_full | Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease |
| title_fullStr | Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease |
| title_full_unstemmed | Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease |
| title_short | Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease |
| title_sort | assessment of serum neopterin as a biomarker in peripheral artery disease |
| topic | inflammation nitro-oxidative stress endothelial progenitor cells hematopoietic progenitor cells physical performance |
| url | https://www.mdpi.com/2075-4418/11/10/1911 |
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