High genetic stability of dengue virus propagated in MRC-5 cells as compared to the virus propagated in vero cells.

High genetic stability of dengue virus propagated in MRC-5 cells as compared to the virus propagated in vero cells.

This work investigated the replication kinetics of the four dengue virus serotypes (DEN-1 to DEN-4), including dengue virus type 4 (DEN-4) recovered from an infectious cDNA clone, in Vero cells and in MRC-5 cells grown on Cytodex 1 microcarriers. DEN-1 strain Hawaii, DEN-2 strain NGC, DEN-3 strain H...

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Bibliographic Details
Main Authors: Chia-Chyi Liu, Shiang-Chi Lee, Michael Butler, Suh-Chin Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2265545?pdf=render

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