Structural Dynamics of the SARS-CoV-2 Spike Protein: A 2-Year Retrospective Analysis of SARS-CoV-2 Variants (from Alpha to Omicron) Reveals an Early Divergence between Conserved and Variable Epitopes

Structural Dynamics of the SARS-CoV-2 Spike Protein: A 2-Year Retrospective Analysis of SARS-CoV-2 Variants (from Alpha to Omicron) Reveals an Early Divergence between Conserved and Variable Epitopes

We analyzed the epitope evolution of the spike protein in 1,860,489 SARS-CoV-2 genomes. The structural dynamics of these epitopes was determined by molecular modeling approaches. The D614G mutation, selected in the first months of the pandemic, is still present in currently circulating SARS-CoV-2 st...

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Bibliographic Details
Main Authors: Patrick Guérin, Nouara Yahi, Fodil Azzaz, Henri Chahinian, Jean-Marc Sabatier, Jacques Fantini
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
SARS-CoV-2 variants
vaccine
facilitating antibodies
neutralizing antibodies
molecular epidemiology
Online Access:https://www.mdpi.com/1420-3049/27/12/3851

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